The Aedes aegypti peritrophic matrix controls arbovirus vector competence through HPx1, a heme-induced peroxidase.

Autor: Octavio A C Talyuli, Jose Henrique M Oliveira, Vanessa Bottino-Rojas, Gilbert O Silveira, Patricia H Alvarenga, Ana Beatriz F Barletta, Asher M Kantor, Gabriela O Paiva-Silva, Carolina Barillas-Mury, Pedro L Oliveira

Publikováno v: PLoS Pathogens, Vol 19, Iss 2, p e1011149 (2023)

Aedes aegypti mosquitoes are the main vectors of arboviruses. The peritrophic matrix (PM) is an extracellular layer that surrounds the blood bolus. It acts as an immune barrier that prevents direct contact of bacteria with midgut epithelial cells dur

Externí odkaz: https://doaj.org/article/e52e6055087042508fa2ad005c5dd9d3

The function and three-dimensional structure of a thromboxane A2/cysteinyl leukotriene-binding protein from the saliva of a mosquito vector of the malaria parasite.

Autor: Patricia H Alvarenga, Ivo M B Francischetti, Eric Calvo, Anderson Sá-Nunes, José M C Ribeiro, John F Andersen

Publikováno v: PLoS Biology, Vol 8, Iss 11, p e1000547 (2010)

The highly expressed D7 protein family of mosquito saliva has previously been shown to act as an anti-inflammatory mediator by binding host biogenic amines and cysteinyl leukotrienes (CysLTs). In this study we demonstrate that AnSt-D7L1, a two-domain

Externí odkaz: https://doaj.org/article/4d9bc8d7659a496db0d15d89586da94d

An Overview of D7 Protein Structure and Physiological Roles in Blood-Feeding Nematocera

Autor: Patricia H. Alvarenga, John F. Andersen

Publikováno v: Biology. 12:39

Each time an insect bites a vertebrate host, skin and vascular injury caused by piercing triggers a series of responses including hemostasis, inflammation and immunity. In place, this set of redundant and interconnected responses would ultimately cau

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4ba597d9290d7263ba3276128bdd744e
https://doi.org/10.3390/biology12010039

Functional aspects of evolution in a cluster of salivary protein genes from mosquitoes

Autor: Patricia H. Alvarenga, Denis R. Dias, Xueqing Xu, Ivo M.B. Francischetti, Apostolos G. Gittis, Gabriela Arp, David N. Garboczi, José M.C. Ribeiro, John F. Andersen

Publikováno v: Insect Biochem Mol Biol

The D7 proteins are highly expressed in the saliva of hematophagous Nematocera and bind biogenic amines and eicosanoid compounds produced by the host during blood feeding. These proteins are encoded by gene clusters expressing forms having one or two

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02af240cb00a1de41f6fb700a9654c26
https://doi.org/10.1016/j.ibmb.2022.103785

A physiologic overview of the organ-specific transcriptome of the cattle tick Rhipicephalus microplus

Autor: Josias Alves Machado, Aparecida S. Tanaka, Melina Garcia Guizzo, Renato Martins da Silva, Helga Gomes, Maria Beatriz S. Mota, Milane de Souza Leite, Rafael D. Mesquita, Pedro L. Oliveira, Itabajara da Silva Vaz, Larissa Rezende Vieira, Flávio Alves Lara, Daniele Santos, Evenilton Pessoa Costa, Jorge Moraes, Sirlei Daffre, Rodrigo Dutra Nunes, Ana Caroline P. Gandara, Carlos Logullo, Rodrigo Nunes da Fonseca, Gabriela Alves Sabadin, Patricia H. Alvarenga, Lucas Tirloni, José M. C. Ribeiro, Glória R.C. Braz, Teresa C.F. Assumpção, Adriana Seixas, Andréa Cristina Fogaça

Publikováno v: Scientific Reports
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Scientific Reports, Vol 10, Iss 1, Pp 1-17 (2020)

To further obtain insights into the Rhipicephalus microplus transcriptome, we used RNA-seq to carry out a study of expression in (i) embryos; (ii) ovaries from partially and fully engorged females; (iii) salivary glands from partially engorged female

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60a412522e751a837634ba3a32eaf1ef
https://doi.org/10.1038/s41598-020-75341-w