Zobrazeno 1 - 10
of 171
pro vyhledávání: '"Patricia Greninger"'
Autor:
Nishanth Ulhas Nair, Patricia Greninger, Xiaohu Zhang, Adam A. Friedman, Arnaud Amzallag, Eliane Cortez, Avinash Das Sahu, Joo Sang Lee, Anahita Dastur, Regina K. Egan, Ellen Murchie, Michele Ceribelli, Giovanna S. Crowther, Erin Beck, Joseph McClanaghan, Carleen Klump-Thomas, Jessica L. Boisvert, Leah J. Damon, Kelli M. Wilson, Jeffrey Ho, Angela Tam, Crystal McKnight, Sam Michael, Zina Itkin, Mathew J. Garnett, Jeffrey A. Engelman, Daniel A. Haber, Craig J. Thomas, Eytan Ruppin, Cyril H. Benes
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Combination of anti-cancer drugs is broadly seen as way to overcome the often-limited efficacy of single agents. The design and testing of combinations are however very challenging. Here we present a uniquely large dataset screening over 500
Externí odkaz:
https://doaj.org/article/74d18fafe3754d38962c3b1365fa27b3
Autor:
Yang Sun, Lu Hu, Zhipeng Tao, Gopala K. Jarugumilli, Hannah Erb, Alka Singh, Qi Li, Jennifer L. Cotton, Patricia Greninger, Regina K. Egan, Y. Tony Ip, Cyril H. Benes, Jianwei Che, Junhao Mao, Xu Wu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Previously, the small molecule inhibitor of transcriptional enhanced associate domain (TEAD) MGH-CP1 has been described in stem cells. Here, the authors demonstrate the utility of MGH-CP1 in cancer therapy and find treatment to increase Akt pathway a
Externí odkaz:
https://doaj.org/article/0a919bab3ce842f1938cd997f841b09b
Autor:
Jinyang Cai, Sheeba Jacob, Richard Kurupi, Krista M. Dalton, Colin Coon, Patricia Greninger, Regina K. Egan, Giovanna T. Stein, Ellen Murchie, Joseph McClanaghan, Yuta Adachi, Kentaro Hirade, Mikhail Dozmorov, John Glod, Sosipatros A. Boikos, Hiromichi Ebi, Huaixiang Hao, Giordano Caponigro, Cyril H. Benes, Anthony C. Faber
Publikováno v:
Cell Reports, Vol 40, Iss 4, Pp 111095- (2022)
Summary: Reoccurring/high-risk neuroblastoma (NB) tumors have the enrichment of non-RAS/RAF mutations along the mitogen-activated protein kinase (MAPK) signaling pathway, suggesting that activation of MEK/ERK is critical for their survival. However,
Externí odkaz:
https://doaj.org/article/3169f73446bb4502b9e30b3d5f9b0105
Autor:
Avinash Das Sahu, Joo S Lee, Zhiyong Wang, Gao Zhang, Ramiro Iglesias‐Bartolome, Tian Tian, Zhi Wei, Benchun Miao, Nishanth Ulhas Nair, Olga Ponomarova, Adam A Friedman, Arnaud Amzallag, Tabea Moll, Gyulnara Kasumova, Patricia Greninger, Regina K Egan, Leah J Damon, Dennie T Frederick, Livnat Jerby‐Arnon, Allon Wagner, Kuoyuan Cheng, Seung Gu Park, Welles Robinson, Kevin Gardner, Genevieve Boland, Sridhar Hannenhalli, Meenhard Herlyn, Cyril Benes, Keith Flaherty, Ji Luo, J Silvio Gutkind, Eytan Ruppin
Publikováno v:
Molecular Systems Biology, Vol 15, Iss 3, Pp 1-21 (2019)
Abstract Most patients with advanced cancer eventually acquire resistance to targeted therapies, spurring extensive efforts to identify molecular events mediating therapy resistance. Many of these events involve synthetic rescue (SR) interactions, wh
Externí odkaz:
https://doaj.org/article/3e0d9e37ccd24f31aaa5e8abf6557875
Autor:
Tina L. Yuan, Arnaud Amzallag, Rachel Bagni, Ming Yi, Shervin Afghani, William Burgan, Nicole Fer, Leslie A. Strathern, Katie Powell, Brian Smith, Andrew M. Waters, David Drubin, Ty Thomson, Rosy Liao, Patricia Greninger, Giovanna T. Stein, Ellen Murchie, Eliane Cortez, Regina K. Egan, Lauren Procter, Matthew Bess, Kwong Tai Cheng, Chih-Shia Lee, Liam Changwoo Lee, Christof Fellmann, Robert Stephens, Ji Luo, Scott W. Lowe, Cyril H. Benes, Frank McCormick
Publikováno v:
Cell Reports, Vol 22, Iss 7, Pp 1889-1902 (2018)
Summary: KRAS can bind numerous effector proteins, which activate different downstream signaling events. The best known are RAF, phosphatidylinositide (PI)-3′ kinase, and RalGDS families, but many additional direct and indirect effectors have been
Externí odkaz:
https://doaj.org/article/b9acf930ce7f49cbbf8886d56ca37592
Autor:
Ayaz Najafov, Ioannis K Zervantonakis, Adnan K Mookhtiar, Patricia Greninger, Ryan J March, Regina K Egan, Hoang Son Luu, Daniel G Stover, Ursula A Matulonis, Cyril H Benes, Junying Yuan
Publikováno v:
PLoS Biology, Vol 16, Iss 8, p e2005756 (2018)
Necroptosis is a lytic programmed cell death mediated by the RIPK1-RIPK3-MLKL pathway. The loss of Receptor-interacting serine/threonine-protein kinase 3 (RIPK3) expression and necroptotic potential have been previously reported in several cancer cel
Externí odkaz:
https://doaj.org/article/2e140e19f51e4e62a0336885df594129
Autor:
Byunghee Yoo, Patricia Greninger, Giovanna T Stein, Regina K Egan, Joseph McClanaghan, Anna Moore, Cyril H Benes, Zdravka Medarova
Publikováno v:
PLoS ONE, Vol 13, Iss 7, p e0201046 (2018)
Since microRNAs (miRNAs, miRs) have been implicated in oncogenesis, many of them have been identified as therapeutic targets. Previously we have demonstrated that miRNA-10b acts as a master regulator of the viability of metastatic tumor cells and rep
Externí odkaz:
https://doaj.org/article/7d4e07a6112548db9914389c72aecba7
Autor:
Lei Shi, William Shen, Mindy I. Davis, Ke Kong, Phuong Vu, Supriya K. Saha, Ramzi Adil, Johannes Kreuzer, Regina Egan, Tobie D. Lee, Patricia Greninger, Jonathan H. Shrimp, Wei Zhao, Ting-Yu Wei, Mi Zhou, Jason Eccleston, Jonathan Sussman, Ujjawal Manocha, Vajira Weerasekara, Hiroshi Kondo, Vindhya Vijay, Meng-Ju Wu, Sara E. Kearney, Jeffrey Ho, Joseph McClanaghan, Ellen Murchie, Giovanna S. Crowther, Samarjit Patnaik, Matthew B. Boxer, Min Shen, David T. Ting, William Y. Kim, Ben Z. Stanger, Vikram Deshpande, Cristina R. Ferrone, Cyril H. Benes, Wilhelm Haas, Matthew D. Hall, Nabeel Bardeesy
Publikováno v:
Nature Cancer. 4:365-381
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c3602f7c38d388eae485cdbdd07cffc
https://doi.org/10.1038/s43018-023-00523-0
https://doi.org/10.1038/s43018-023-00523-0
Autor:
Anthony C. Faber, Cyril H. Benes, Mikhail G. Dozmorov, Devraj Basu, Iain M. Morgan, Yue Sun, Hisashi Harada, Jennifer E. Koblinski, Sosipatros A. Boikos, Maninderjit S. Ghotra, Krista M. Dalton, Patricia Greninger, Ellen Murchie, Regina K. Egan, Giovanna Stein Crowther, Rishabh Khatri, Colin M. Coon, Madhavi Puchalapalli, Bin Hu, Jinyang Cai, Ayesha T. Chawla, Sheeba Jacob, Konstantinos V. Floros, Richard Kurupi
Biological importance of Gab1 in HNSCC cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd1755ff52a1c2abd42395916bda423b
https://doi.org/10.1158/2767-9764.22545726.v1
https://doi.org/10.1158/2767-9764.22545726.v1
Autor:
Nabeel Bardeesy, Cyril H. Benes, Lipika Goyal, Dejan Juric, Andrew X. Zhu, John D. Gordan, James R. Stone, Charlotte S. Walmsley, Daniel E. McLoughlin, Christopher J. Pinto, Islam Baiev, Vikram Deshpande, Cristina R. Ferrone, Xunqin Yin, Meng-Ju Wu, Regina Egan, Joshua Merritt, Ramzi Adil, Patricia Greninger, Phuong Vu, Lei Shi, Yuanli Zhen, Qibiao Wu
Supplementary Table from EGFR Inhibition Potentiates FGFR Inhibitor Therapy and Overcomes Resistance in FGFR2 Fusion–Positive Cholangiocarcinoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::931e04b614aba9b77872a721a0f534da
https://doi.org/10.1158/2159-8290.22540895
https://doi.org/10.1158/2159-8290.22540895