Dissolving microneedles containing aminolevulinic acid improves protoporphyrin IX distribution

Autor: Sebastião Pratavieira, Ryan F. Donnelly, Marlon Rodrigues Garcia, José Dirceu Vollet-Filho, Patricia González-Vázquez, Andi Dian Permana, Michelle Barreto Requena, Clara Maria Gonçalves de Faria, Vanderlei Salvador Bagnato

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

One important limitation of topical photodynamic therapy (PDT) is the limited tissue penetration of precursors. Microneedles (MNs) are minimally invasive devices used to promote intradermal drug delivery. Dissolving MNs contain drug-associated to pol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0267ac836345e99bf6b04c2e6353a524

Novel bilayer dissolving microneedle arrays with concentrated PLGA nano-microparticles for targeted intradermal delivery: Proof of concept

Autor: Lalitkumar K. Vora, Raghu Thakur, Patricia González-Vázquez, Pradeep R. Vavia, Ryan F. Donnelly, Eneko Larrañeta

Publikováno v: Vora, L, Donnelly, R F, Larrañeta, E, González-Vázquez, P, Thakur, R R S & Vavia, P R 2017, ' Novel bilayer dissolving microneedle arrays with concentrated PLGA nano-microparticles for targeted intradermal delivery: Proof of concept ', Journal of Controlled Release . https://doi.org/10.1016/j.jconrel.2017.10.005

Polymeric microneedle (MN) arrays continue to receive growing attention due to their ability to bypass the skin's stratum corneum barrier in a minimally-invasive fashion and achieve enhanced transdermal drug delivery and “targeted” intradermal va

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46bc20277f31190ce4ce1c050944ea9d
https://pubmed.ncbi.nlm.nih.gov/29037785

A proposed model membrane and test method for microneedle insertion studies

Autor: Rebecca E. M. Lutton, Jessica Moore, Eva M. Vicente-Pérez, Ryan F. Donnelly, Patricia González-Vázquez, A. David Woolfson, Eneko Larrañeta

Publikováno v: International Journal of Pharmaceutics

Graphical abstract
A commercial polymeric film (Parafilm M®, a blend of a hydrocarbon wax and a polyolefin) was evaluated as a model membrane for microneedle (MN) insertion studies. Polymeric MN arrays were inserted into Parafilm M® (PF) and a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::792db51c58c449ba6c2d00ff3639502c
http://europepmc.org/articles/PMC4111867

Hydrogel-Forming Microneedle Arrays Allow Detection of Drugs and Glucose In Vivo: Potential for Use in Diagnosis and Therapeutic Drug Monitoring

Autor: Teng Meng, Steven E. J. Bell, Ryan F. Donnelly, Ester Caffarel-Salvador, Barbara M. Torrisi, Aaron Brady, Eva M. Vicente-Pérez, Ana Alonso-Vicente, Eyman Eltayib, Karen Mooney, Helen O. McCarthy, James McElnay, Colin P. McCoy, David S. Jones, Patricia González-Vázquez

Publikováno v: Caffarel-Salvador, E, Brady, A J, Eltayib, E, Meng, T, Alonso-Vicente, A, Gonzalez-Vazquez, P, Torrisi, B M, Vicente-Perez, E M, Mooney, K, Jones, D S, Bell, S E J, McCoy, C P, McCarthy, H O, McElnay, J C & Donnelly, R F 2015, ' Hydrogel-Forming Microneedle Arrays Allow Detection of Drugs and Glucose In Vivo: Potential for Use in Diagnosis and Therapeutic Drug Monitoring ', PloS one, vol. 10, no. 12, e0145644 . https://doi.org/10.1371/journal.pone.0145644
PLoS ONE
PLoS ONE, Vol 10, Iss 12, p e0145644 (2015)

We describe, for the first time the use of hydrogel-forming microneedle (MN) arrays for minimally-invasive extraction and quantification of drug substances and glucose from skin in vitro and in vivo. MN prepared from aqueous blends of hydrolysed poly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81e95e994218fc9be0adf0708d52ccd5
https://pure.qub.ac.uk/en/publications/hydrogelforming-microneedle-arrays-allow-detection-of-drugs-and-glucose-in-vivo-potential-for-use-in-diagnosis-and-therapeutic-drug-monitoring(20d1751d-1b65-46a9-bd02-008b562e0360).html