Výsledky vyhledávání - "Patricia González-Bulnes"

Integrated Synthetic, Pharmacological, and Computational Investigation of cis-2-(3,5-Dichlorophenylcarbamoyl)cyclohexanecarboxylic Acid Enantiomers As Positive Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 4

Autor: Jesús Giraldo, Jean-Philippe Pin, Patricia González-Bulnes, Amadeu Llebaria, Christo Z. Christov, Cyril Goudet, Tatyana Karabencheva, Fanny Malhaire

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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2-(3,5-Dichlorophenylcarbamoyl)cyclohexanecarboxylic acid (1) is a potent and selective positive allosteric modulator of metabotropic glutamate receptor subtype 4 (mGluR4). The activity of 1 was reported to reside in the cis diastereomer with equal p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::079bd8919e13dca06af47d2aa670f4fd
https://doi.org/10.1002/cmdc.201000378

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Overlapping binding sites drive allosteric agonism and positive cooperativity in type 4 metabotropic glutamate receptors

Autor: Jesús Giraldo, Jean-Philippe Pin, Amadeu Llebaria, Fanny Malhaire, Pauline Scholler, Cyril Goudet, Xavier Rovira, Patricia González-Bulnes, Jordi Rodrigo

Publikováno v: FASEB Journal
FASEB Journal, Federation of American Society of Experimental Biology, 2015, 29 (1), pp.116--30. ⟨10.1096/fj.14-257287⟩

International audience; Type 4 metabotropic glutamate (mGlu4) receptors are emerging targets for the treatment of various disorders. Accordingly, numerous mGlu4-positive allosteric modulators (PAMs) have been identified, some of which also display ag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::200889aa0a9b8b9e098b0a511c8504af
https://hal.archives-ouvertes.fr/hal-01943324

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Exploring the active conformation of cyclohexane carboxylate positive allosteric modulators of the type 4 metabotropic glutamate receptor

Autor: Jesús Giraldo, Youssef Harrak, Jean-Philippe Pin, Amadeu Llebaria, Ana Trapero, Xavier Rovira, Patricia González-Bulnes, Fanny Malhaire, Cyril Goudet

Publikováno v: ChemMedChem
ChemMedChem, 2014, 9 (12), pp.2685--98. ⟨10.1002/cmdc.201402190⟩
ChemMedChem, Wiley-VCH Verlag, 2014, 9 (12), pp.2685--98. ⟨10.1002/cmdc.201402190⟩

The active conformation of a family of metabotropic glutamate receptor subtype 4 (mGlu4 ) positive allosteric modulators (PAMs) with the cyclohexane 1,2-dicarboxylic scaffold present in cis-2-(3,5-dichlorophenylcarbamoyl)cyclohexanecarboxylic acid (V

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5762b8379e53e37e0c3fe9dbdb9fc02a
https://hal.science/hal-01943327

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Potent aminocyclitol glucocerebrosidase inhibitors are subnanomolar pharmacological chaperones for treating gaucher disease

Autor: Ana Trapero, Amadeu Llebaria, Terry D. Butters, Patricia González-Bulnes

Publikováno v: Journal of medicinal chemistry. 55(9)

Amino-myo-inositol derivatives have been found to be potent inhibitors of glucocerebrosidase (GCase), the β-glucosidase enzyme deficient in Gaucher disease (GD). When tested using lymphoblasts derived from patients with GD homozygous for N370S or L4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5caa922e5b35a81be3c71bcec4a56789
http://ora.ox.ac.uk/objects/uuid:5302a5db-de08-419a-8c2e-4338f0be0a6c

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PG12, a phospholipid analog with potent antimalarial activity, inhibits Plasmodium falciparum CTP:phosphocholine cytidylyltransferase activity

Autor: Rachel Cerdan, April M. Bobenchik, Choukri Ben Mamoun, Yoann Augagneur, Amadeu Llebaria, Henri Vial, Patricia González-Bulnes

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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In the human malaria parasite Plasmodium falciparum, the synthesis of the major and essential membrane phospholipid, phosphatidylcholine, occurs via the CDP-choline and the serine decarboxylase phosphoethanolamine methylation (SDPM) pathways, which a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55cc15fbf3a3a8feecde080b9e200c15
https://pubmed.ncbi.nlm.nih.gov/21705805

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2-Aminohydroxamic acid derivatives as inhibitors of Bacillus cereus phosphatidylcholine preferred phospholipase C PC-PLCBc

Autor: Patricia González-Bulnes, Antonio Delgado, Amadeu Llebaria, Albert González-Roura, Josefina Casas, Daniel Canals

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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Phosphatidylcholine preferring phospholipase C (PC-PLC) is an important enzyme that plays a key role in a variety of cellular events and lipid homoeostases. Bacillus cereus phospholipase C (PC-PLCBc) has antigenic similarity with the elusive mammalia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04521d3b28f26a8d7a02caf9c923d9ed
http://hdl.handle.net/10261/46904

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Practical synthesis of (-)-1-amino-1-deoxy-myo-inositol from achiral precursors

Autor: Amadeu Llebaria, Antonio Delgado, Josefina Casas, Patricia González-Bulnes

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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6 pages, 3 schemes.-- PMID: 17524374 [PubMed].-- Printed version published on Sep 3, 2007.
A new synthesis of enantiomerically pure 1-amino-1-deoxy-myo-inositol is reported. The route described employs pbenzoquinone, an achiral compound, as the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c120610192362c5997d9933e621f8db
http://hdl.handle.net/10261/9509

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