Germ-line mutations in epidermal growth factor receptor (EGFR) are rare but may contribute to oncogenesis: A novel germ-line mutation in EGFR detected in a patient with lung adenocarcinoma

Autor: Aurora Astudillo, Patricia González-Arriaga, Primitiva Menéndez, Fernando Iglesias, José M. Freije, Adonina Tardón, Ana S. Pitiot, Milagros Balbín, Fernando G. Osorio, Íñigo Santamaría, Pilar Blay, Irene Centeno

Publikováno v: RUO. Repositorio Institucional de la Universidad de Oviedo
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BMC Cancer
BMC Cancer, Vol 11, Iss 1, p 172 (2011)

Background A subset of lung cancer patients harbour EGFR somatic mutations in their tumours and are candidates for treatment with EGFR tyrosine kinase inhibitors. In a few cases EGFR mutations have also been found in the germ line, suggesting a role

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86426ddc93830765ded608e96c1d89df
http://hdl.handle.net/10651/6393

Matrix metalloproteinase- 9 polymorphisms in the diagnosis of prostate cancer. A preliminary experience

Autor: Rodrigo, Gil Ugarteburu, Manuel, Rivas del Fresno, Iván, González Rodríguez, Patricia, González Arriaga, Felicitas, López Cima, Ana, Fernández Samoano, Isabel, Fernández García, Priscila, Benito García, Valentín, Muruamendiaraz Fernández, Adonina, Tardón

Publikováno v: Archivos espanoles de urologia. 63(2)

Polymorphisms Q279R, P574R and -1562 C/T of matrix metalloproteinase-9 (MMP-9) gene have been linked with the risk of cancer and with tumoral aggressiveness in various types of cancer. So far there are no studies in the literature analysing the link

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4bd9efc1712171d2b84c7812d0826da8
https://pubmed.ncbi.nlm.nih.gov/20354277

Polimorfismos de la metaloproteasa de matriz 9 (MMP-9) en el diagnóstico del carcinoma prostático: Experiencia preliminar

Autor: Adonina Tardón, Ana Fernández Samoano, Manuel Rivas del Fresno, Priscila Benito García, Felicitas López Cima, Iván González Rodríguez, Rodrigo Gil Ugarteburu, Valentín Muruamendiaraz Fernández, Patricia González Arriaga, Isabel Garcia

Publikováno v: Archivos Españoles de Urología (Ed. impresa), Volume: 63, Issue: 2, Pages: 125-132, Published: MAR 2010
Archivos Españoles de Urología (Ed. impresa) v.63 n.2 2010
SciELO España. Revistas Científicas Españolas de Ciencias de la Salud
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Los polimorfismos Q279R, P574R y -1562 C/T en el gen de la MMP-9 se han relacionado con el riesgo de padecer cáncer y con la agresividad tumoral de varios tipos de cánceres. Hasta ahora no existen estudios en la literatura que analicen la asociaci�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f361eceb7fd6961e1e68826172484f2
http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0004-06142010000200008&lng=en&tlng=en

Polymorphism+17 C/G in Matrix Metalloprotease MMP8 decreases lung cancer risk

Autor: Teresa Pascual, Xose S. Puente, Ana Fernández-Somoano, Patricia González-Arriaga, M Felicitas López-Cima, Adonina Tardón, Manuel G. Marrón

Publikováno v: WOS
BMC Cancer
RUO. Repositorio Institucional de la Universidad de Oviedo
instname
BMC Cancer, Vol 8, Iss 1, p 378 (2008)

Background Matrix metalloproteases (MMPs) constitute a family of enzymes capable of degrading different components of the extracellular matrix and are implicated in the invasion of tumor cells through the basement membrane. Polymorphisms in MMP genes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a14f95004f0353d6425ca3487b89c58
http://hdl.handle.net/10651/23715

Genetic polymorphisms in MMP 2, 9 and 3genes modify lung cancer risk and survival

Autor: Arturo García-Alvarez, Teresa Pascual, Adonina Tardón, Patricia González-Arriaga, M Felicitas López-Cima, Ana Fernández-Somoano

Publikováno v: BMC Cancer, Vol 12, Iss 1, p 121 (2012)
BMC Cancer
SCOPUS
RUO. Repositorio Institucional de la Universidad de Oviedo
instname

Background Matrix metalloproteases (MMPs) are proteolytic enzymes that contribute to all stages of tumour progression, including the later stages of invasion and metastasis. Genetic variants in the MMP genes may influence the biological function of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74f962641325ed608ebea370862c8be4