Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Patricia Gomez de Santos"'
Autor:
Mikel Dolz, Ivan Mateljak, Daniel Méndez-Sánchez, Israel Sánchez-Moreno, Patricia Gomez de Santos, Javier Viña-Gonzalez, Miguel Alcalde
Publikováno v:
Frontiers in Catalysis, Vol 2 (2022)
At present, the end-of-life management of thermoset composite epoxy resins is limited to incineration and landfill storage, highlighting the demand for the development of more sustainable measures. Due to their broad spectrum of C-H oxyfunctionalizat
Externí odkaz:
https://doaj.org/article/3771f9e76ef149748aaa0c65099b8ea3
Autor:
Patricia Gomez de Santos, Alejandro González‐Benjumea, Angela Fernandez‐Garcia, Carmen Aranda, Yinqi Wu, Andrada But, Patricia Molina‐Espeja, Diana M. Maté, David Gonzalez‐Perez, Wuyuan Zhang, Jan Kiebist, Katrin Scheibner, Martin Hofrichter, Katarzyna Świderek, Vicent Moliner, Julia Sanz‐Aparicio, Frank Hollmann, Ana Gutiérrez, Miguel Alcalde
Publikováno v:
Angewandte Chemie (International Edition), 62(9)
10 páginas.- 4 figuras.- 2 tablas.- 30 referencias.- Supporting information for this article is given via a link at the end of the document https://onlinelibrary.wiley.com/doi/10.1002/anie.202217372
he hydroxylation of fatty acids is an appeali
he hydroxylation of fatty acids is an appeali
Autor:
Martin Hofrichter, Manh Dat Hoang, Jan Kiebist, René Ullrich, Christiane Liers, Katrin Scheibner, Miguel Alcalde, Patricia Gomez de Santos, Harald Kellner
Publikováno v:
Appl Environ Microbiol
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC. Repositorio Institucional del CSIC
instname
[EN] Fungal unspecific peroxygenases (UPOs) are emergent biocatalysts that perform highly selective C-H oxyfunctionalizations of organic compounds, yet their heterologous production at high levels is required for their practical use in synthetic chem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a742ef2eafddc9c3e5f92215e006db30
https://europepmc.org/articles/PMC8432526/
https://europepmc.org/articles/PMC8432526/
Biocatalytic Aromaticity-Breaking Epoxidation of Naphthalene and Nucleophilic Ring-Opening Reactions
Autor:
Florian Tieves, Adrian C. Whitwood, Martin Pabst, Sabry H. H. Younes, Frank Hollmann, Gideon Grogan, Huanhuan Li, Wuyuan Zhang, Patricia Gomez de Santos, Miguel Alcalde
Publikováno v:
ACS Catalysis
ACS Catalysis, 11(5)
ACS Catalysis, 11(5)
Aromatic hydroxylation reactions catalyzed by heme-thiolate enzymes proceed via an epoxide intermediate. These aromatic epoxides could be valuable building blocks for organic synthesis giving access to a range of chiral trans-disubstituted cyclohexad
Autor:
Frank Hollmann, Florian Tieves, Caroline E. Paul, Alexander T. Kaczmarek, Günter Schwarz, Morten M. C. H. van Schie, Miguel Alcalde, Patricia Gomez de Santos, Isabel W. C. E. Arends
Publikováno v:
ChemCatChem, 12(12)
H2O2 can be accepted by several peroxygenases as a clean oxidant, able to supply both the necessary electrons and oxygen atom at the same time. The biocatalysts, in turn, are able to catalyse an array of interesting oxygen insertion reactions at enan
Evolved Peroxygenase-Aryl Alcohol Oxidase Fusions for Self-Sufficient Oxyfunctionalization Reactions
Autor:
Manh Dat Hoang, Sofia Lazaro, Frank Hollmann, Javier Viña-Gonzalez, Miguel Alcalde, Israel Sánchez-Moreno, Patricia Gomez de Santos, Anton Glieder
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
ACS Catalysis, 10(22)
instname
ACS Catalysis, 10(22)
[EN] Fungal peroxygenases are deemed emergent biocatalysts for selective C¿H bond oxyfunctionalization reactions. In this study, we have engineered a functional and stable self-sufficient chimeric peroxygenase-oxidase fusion. The bifunctional biocat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::593f56f4dd6f2da749a1bd694524b53e
http://hdl.handle.net/10261/227270
http://hdl.handle.net/10261/227270
Autor:
Florian Tieves, Frank Hollmann, Victor Guallar, Sabry H. H. Younes, Martin Hofrichter, Marina Cañellas, Patricia Molina-Espeja, Patricia Gomez de Santos, Miguel Alcalde
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
ACS Catalysis
ACS Catalysis, 8(6)
instname
ACS Catalysis
ACS Catalysis, 8(6)
Propranolol is a widely used beta-blocker that is metabolized by human liver P450 monooxygenases into equipotent hydroxylated human drug metabolites (HDMs). It is paramount for the pharmaceutical industry to evaluate the toxicity and activity of thes
Autor:
Antonio Ballesteros, Javier Martin-Diaz, Marisa Rodriguez, Jose M. Sanchez-Ruiz, Miguel Alcalde, Spencer M. Whitney, Paloma Santos-Moriano, Eva Garcia-Ruiz, Bernardo J. Gómez-Fernández, Monica Garcia, Valeria A. Risso, Francisco J. Plou, Patricia Gomez de Santos
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Scientific Reports
Digibug. Repositorio Institucional de la Universidad de Granada
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Digital.CSIC. Repositorio Institucional del CSIC
instname
Scientific Reports
Digibug. Repositorio Institucional de la Universidad de Granada
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Rubisco is an ancient, catalytically conserved yet slow enzyme, which plays a central role in the biosphere’s carbon cycle. The design of Rubiscos to increase agricultural productivity has hitherto relied on the use of in vivo selection systems, pr
Autor:
Florian Tieves, Miguel Alcalde, Fadia V. Cervantes, Patricia Gomez de Santos, Francisco J. Plou, Frank Hollmann
Publikováno v:
Tetrahedron, 75(13)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC. Repositorio Institucional del CSIC
instname
[EN] By mimicking the role of human liver P450 monooxygenases, fungal unspecific peroxygenases (UPOs) can perform a range of highly selective oxyfunctionalization reactions on pharmacological compounds, including O-dealkylations and hydroxylations, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c7e7437651a8547dbba1fa32267c25b
http://resolver.tudelft.nl/uuid:59c2777b-75b5-4c26-86cf-e37ef32d28a9
http://resolver.tudelft.nl/uuid:59c2777b-75b5-4c26-86cf-e37ef32d28a9
Autor:
Florian, Tieves, Sébastien Jean-Paul, Willot, Morten Martinus Cornelis Harald, van Schie, Marine Charlène Renée, Rauch, Sabry Hamdy Hamed, Younes, Wuyuan, Zhang, JiaJia, Dong, Patricia, Gomez de Santos, John Mick, Robbins, Bettina, Bommarius, Miguel, Alcalde, Andreas Sebastian, Bommarius, Frank, Hollmann
Publikováno v:
Angewandte Chemie (International Ed. in English)
An increasing number of biocatalytic oxidation reactions rely on H2O2 as a clean oxidant. The poor robustness of most enzymes towards H2O2, however, necessitates more efficient systems for in situ H2O2 generation. In analogy to the well‐known forma