Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Patricia Gomez‐Suaga"'
Autor:
Andrea Markovinovic, Sandra M. Martín-Guerrero, Gábor M. Mórotz, Shaakir Salam, Patricia Gomez-Suaga, Sebastien Paillusson, Jenny Greig, Younbok Lee, Jacqueline C. Mitchell, Wendy Noble, Christopher C.J. Miller
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-17 (2024)
Abstract Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are clinically linked major neurodegenerative diseases. Notably, TAR DNA-binding protein-43 (TDP43) accumulations are hallmark pathologies of FTD/ALS and mutations in the
Externí odkaz:
https://doaj.org/article/959726ed7de941829423f9bf27ab624c
Publikováno v:
Neural Regeneration Research, Vol 19, Iss 7, Pp 1407-1408 (2024)
Externí odkaz:
https://doaj.org/article/32f763b5ba4c4c36a1bf110ec0837618
Autor:
Naomi Hartopp, Dawn H W. Lau, Sandra M. Martin-Guerrero, Andrea Markovinovic, Gábor M. Mórotz, Jenny Greig, Elizabeth B. Glennon, Claire Troakes, Patricia Gomez-Suaga, Wendy Noble, Christopher C.J. Miller
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Signaling between the endoplasmic reticulum (ER) and mitochondria regulates many neuronal functions that are perturbed in amyotrophic lateral sclerosis (ALS) and perturbation to ER-mitochondria signaling is seen in cell and transgenic models of ALS.
Externí odkaz:
https://doaj.org/article/ab769bb8dd764b90914229b46ae9481b
Autor:
Gábor M. Mórotz, Elizabeth B. Glennon, Patricia Gomez-Suaga, Dawn H. W. Lau, Eleanor D. Robinson, Éva Sedlák, Alessio Vagnoni, Wendy Noble, Christopher C. J. Miller
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-16 (2019)
Abstract Cyclin dependent kinase-5 (cdk5)/p35 is a neuronal kinase that regulates key axonal and synaptic functions but the mechanisms by which it is transported to these locations are unknown. Lemur tyrosine kinase-2 (LMTK2) is a binding partner for
Externí odkaz:
https://doaj.org/article/c1a67a677a2d464dac0f9c9c50fcb0e5
Autor:
Eva Alegre-Cortés, Alberto Giménez-Bejarano, Elisabet Uribe-Carretero, Marta Paredes-Barquero, André R. A. Marques, Mafalda Lopes-da-Silva, Otília V. Vieira, Saray Canales-Cortés, Pedro J. Camello, Guadalupe Martínez-Chacón, Ana Aiastui, Roberto Fernández-Torrón, Adolfo López de Munain, Patricia Gomez-Suaga, Mireia Niso-Santano, Rosa A. González-Polo, José M. Fuentes, Sokhna M. S. Yakhine-Diop
Publikováno v:
Cells, Vol 11, Iss 19, p 3018 (2022)
Myotonic dystrophy type 1 (DM1) is an autosomal dominant disease caused by a CTG repeat expansion in the 3′ untranslated region of the dystrophia myotonica protein kinase gene. AKT dephosphorylation and autophagy are associated with DM1. Autophagy
Externí odkaz:
https://doaj.org/article/63ec18c48d0044c082b29aaa2f385fd7
Autor:
Dawn H.W. Lau, Sebastien Paillusson, Naomi Hartopp, Huzefa Rupawala, Gábor M. Mórotz, Patricia Gomez-Suaga, Jenny Greig, Claire Troakes, Wendy Noble, Christopher C.J. Miller
Publikováno v:
Neurobiology of Disease, Vol 143, Iss , Pp 105020- (2020)
Signaling between the endoplasmic reticulum (ER) and mitochondria regulates a number of key neuronal functions, many of which are perturbed in Alzheimer's disease. Moreover, damage to ER-mitochondria signaling is seen in cell and transgenic models of
Externí odkaz:
https://doaj.org/article/fcc36096cd214dbfa79e4bc3e131f481
Autor:
Dina Dakkak, Saskia Pollack, Tong Guo, George Chennell, Patricia Gomez Suaga, Wendy Noble, Diane P Hanger
The autophagy-lysosomal pathway plays a critical role in the clearance of tau protein aggregates that deposit in the brain in tauopathies, including Alzheimer’s disease and defects in this system are associated with disease pathogenesis. Here, we r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97f890c6aaae5da59fc365cb6ac197fc
https://doi.org/10.21203/rs.3.rs-1522321/v1
https://doi.org/10.21203/rs.3.rs-1522321/v1
Autor:
Patricia Gomez‐Suaga, Gábor M. Mórotz, Andrea Markovinovic, Sandra M. Martín‐Guerrero, Elisavet Preza, Natalia Arias, Keith Mayl, Afra Aabdien, Vesela Gesheva, Agnes Nishimura, Ambra Annibali, Younbok Lee, Jacqueline C. Mitchell, Selina Wray, Christopher Shaw, Wendy Noble, Christopher C. J. Miller
Publikováno v:
Gomez Suaga, P, Morotz, G, Markovinovic, A, Martin Guerrero, S, Preza, E, Arias Del Castillo, N, Mayl, K, Aabdien, A, Gesheva, V, Nishimura, A, Annibali, A, Lee, Y, Mitchell, J, Wray, S, Shaw, C, Noble, W & Miller, C 2022, ' Disruption of ER-mitochondria tethering and signalling in C9orf72-associated amyotrophic lateral sclerosis and frontotemporal dementia ', AGING CELL, vol. 21, no. 2, e13549 . https://doi.org/10.1111/acel.13549
Hexanucleotide repeat expansions in C9orf72 are the most common cause of familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The mechanisms by which the expansions cause disease are not properly understood but a favoured r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87469f549ade5e5a926eca0967b2b02d
https://pubmed.ncbi.nlm.nih.gov/35026048
https://pubmed.ncbi.nlm.nih.gov/35026048
Autor:
Rosa A. González-Polo, Patricia Gomez-Suaga, José M. Fuentes, Mireia Niso-Santano, José Manuel Bravo-San Pedro
Publikováno v:
Cell Death and Disease, Vol 9, Iss 3, Pp 1-12 (2018)
Cell Death and Disease
Cell Death and Disease, Nature Publishing Group, 2018, 9, pp.337. ⟨10.1038/s41419-017-0079-3⟩
Cell Death & Disease
Cell Death and Disease
Cell Death and Disease, Nature Publishing Group, 2018, 9, pp.337. ⟨10.1038/s41419-017-0079-3⟩
Cell Death & Disease
Abstract Mitochondria form close physical contacts with a specialized domain of the endoplasmic reticulum (ER), known as the mitochondria-associated membrane (MAM). This association constitutes a key signaling hub to regulate several fundamental cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc411e6b7173b96d21a890b5c0f59a9c
http://link.springer.com/article/10.1038/s41419-017-0079-3
http://link.springer.com/article/10.1038/s41419-017-0079-3
Autor:
Patricia Gomez-Suaga, Sokhna M S Yakhine-Diop, Rosa A. González-Polo, Rubén Gómez-Sánchez, Mireia Niso-Santano, Mario Rodríguez-Arribas, José M. Fuentes, Guadalupe Martínez-Chacón, J. M Bravo San Pedro
Publikováno v:
Rodríguez-Arribas, M, Yakhine-Diop, S M S, Pedro, J M B S, Gómez-Suaga, P, Gómez-Sánchez, R, Martínez-Chacón, G, Fuentes, J M, González-Polo, R A & Niso-Santano, M 2016, ' Mitochondria-Associated Membranes (MAMs) : Overview and Its Role in Parkinson’s Disease ', Molecular Neurobiology, pp. 1-17 . https://doi.org/10.1007/s12035-016-0140-8
Europe PubMed Central
Europe PubMed Central
Mitochondria-associated membranes (MAMs) are structures that regulate physiological functions between endoplasmic reticulum (ER) and mitochondria in order to maintain calcium signaling and mitochondrial biogenesis. Several proteins located in MAMs, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2d9954e0917bba269fe6c366106fb61
https://hdl.handle.net/11370/1b8197e2-8cb3-4d39-9ef2-7f33943e4722
https://hdl.handle.net/11370/1b8197e2-8cb3-4d39-9ef2-7f33943e4722