Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Patricia García-Sanz"'
Autor:
Irene Costa-Laparra, Elena Juárez-Escoto, Carlos Vicario, Rosario Moratalla, Patricia García-Sanz
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
IntroductionAlzheimer’s disease remains the most common neurodegenerative disorder, depicted mainly by memory loss and the presence in the brain of senile plaques and neurofibrillary tangles. This disease is related to several cellular alterations
Externí odkaz:
https://doaj.org/article/0dff6d7f3a0147359f53a8838734dd7c
Autor:
Lorena Aguilera-Cobos, Patricia García-Sanz, María Piedad Rosario-Lozano, M. Gonzalo Claros, Juan Antonio Blasco-Amaro
Publikováno v:
Frontiers in Public Health, Vol 11 (2023)
BackgroundPersonalized medicine (PM) is now the new frontier in patient care. The application of this new paradigm extends to various pathologies and different patient care phases, such as diagnosis and treatment. Translating biotechnological advance
Externí odkaz:
https://doaj.org/article/37f5bae802a649e29528ed09083bb876
Autor:
Mónica Gómez-Benito, Noelia Granado, Patricia García-Sanz, Anne Michel, Mireille Dumoulin, Rosario Moratalla
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Alpha-synuclein (α-Syn) is a key protein involved in Parkinson's disease (PD) pathology. PD is characterized by the loss of dopaminergic neuronal cells in the substantia nigra pars compacta and the abnormal accumulation and aggregation of α-Syn in
Externí odkaz:
https://doaj.org/article/d5ab88ced7474a9a857c7a0a171b5364
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract Oxidative stress constitutes a major cause for increased risk of congenital malformations associated to severe hyperglycaemia during pregnancy. Mutations in the gene encoding the transcription factor ALX3 cause congenital craniofacial and ne
Externí odkaz:
https://doaj.org/article/4d468524762b464b86e230b22717eda6
Autor:
Oskar Ortiz, Patricia García-Sanz, Samuel Alberquilla, Agnès Gruart, José M. Delgado-García, Oscar Solís, Adrián Sanz-Magro, Rosario Moratalla, Isabel Espadas
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Cerebral Cortex (New York, NY)
instname
Cerebral Cortex (New York, NY)
Dopamine receptors play an important role in motivational, emotional, and motor responses. In addition, growing evidence suggests a key role of hippocampal dopamine receptors in learning and memory. It is well known that associative learning and syna
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bafaf15e90b26b81f06bcc48e8d6e981
https://doi.org/10.1093/cercor/bhaa354
https://doi.org/10.1093/cercor/bhaa354
Publikováno v:
Movement Disorders, 1-17. WILEY
STARTPAGE=1;ENDPAGE=17;TITLE=Movement Disorders
Movement Disorders
STARTPAGE=1;ENDPAGE=17;TITLE=Movement Disorders
Movement Disorders
Parkinson's disease (PD) is a progressive neurodegenerative disease where dopaminergic neurons in the substantia nigra are lost, resulting in a decrease in striatal dopamine and, consequently, motor control. Dopaminergic degeneration is associated wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b230ad4ffd12857e036fa9d59617a7d
https://doi.org/10.1002/mds.28396
https://doi.org/10.1002/mds.28396
Autor:
Patricia García Sanz
Publikováno v:
Portal De Realidad Extendida de la Universidad de Sevilla.
Parkinson's disease (PD) is the most prevalent neurodegenerative movement disorders, where dopaminergic neurons in the Substantia Nigra (SNpc) are lost, resulting in a decrease in striatal dopamine and, subsequently, motor control failure and diagnos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3768a3ebb5c347c262978f6fcb96b61
https://doi.org/10.35466/ra2021n6390
https://doi.org/10.35466/ra2021n6390
Behavioral sensitization and cellular responses to psychostimulants are reduced in D2R knockout mice
Autor:
Ramon Trullas, Patricia García-Sanz, Noelia Granado, Rafael Maldonado, M. Gustavo Murer, Ana B. Martín, Oscar Solís, Rosario Moratalla, Petar Podlesniy, Adrián Sanz-Magro
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Repeated cocaine exposure causes long-lasting neuroadaptations that involve alterations in cellular signaling and gene expression mediated by dopamine in different brain regions, such as the striatum. Previous studies have pointed out to the dopamine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::615464907f6cee5ea3d8affc89eb87cf
https://doi.org/10.1111/adb.12840
https://doi.org/10.1111/adb.12840
Autor:
Rosario Moratalla, Patricia García-Sanz, Carlos Vicario, Isabel Espadas, Antonia Gutierrez, Guillermo Bueno-Gil, Jaime Kulisevsky, Lorena Orgaz, Pablo Mir, José M. Fuentes, Rosa A. González-Polo, Jose Carlos Davila, Eva Rodríguez-Traver
Publikováno v:
Movement Disorders. 32:1409-1422
Background Heterozygous mutations in the GBA1 gene, which encodes the lysosomal enzyme β-glucocerebrosidase-1, increase the risk of developing Parkinson's disease, although the underlying mechanisms remain unclear. The aim of this study was to explo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39de4e4d772fd9507122dd5952e9f1d9
https://doi.org/10.1002/mds.27119
https://doi.org/10.1002/mds.27119
Publikováno v:
Neurotoxicity Research. 30:67-75
Perturbations in the cerebral levels of various amino acids are associated with neurological disorders, and previous studies have suggested that such alterations have a role in the motor and non-motor symptoms of Parkinson's disease. However, the dir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fdb73b5c97743164a543fe11ca84c97
https://doi.org/10.1007/s12640-016-9612-x
https://doi.org/10.1007/s12640-016-9612-x