Stress-Independent Activation of XBP1s and/or ATF6 Reveals Three Functionally Diverse ER Proteostasis Environments

Autor: Matthew D. Shoulders, Lisa M. Ryno, Joseph C. Genereux, James J. Moresco, Patricia G. Tu, Chunlei Wu, John R. Yates, III, Andrew I. Su, Jeffery W. Kelly, R. Luke Wiseman

Publikováno v: Cell Reports, Vol 3, Iss 4, Pp 1279-1292 (2013)

The unfolded protein response (UPR) maintains endoplasmic reticulum (ER) proteostasis through the activation of transcription factors such as XBP1s and ATF6. The functional consequences of these transcription factors for ER proteostasis remain poorly

Externí odkaz: https://doaj.org/article/7fe6e7d4d578476c93671cd01d2aea31

Mass spectrometry-based shotgun proteomic analysis of C. elegans protein complexes

Autor: Bryan R. Fonslow, John R. Yates, James J. Moresco, Antti P. Aalto, Patricia G. Tu, Amy E. Pasquinelli, Andrew Dillin

Publikováno v: Fonslow, B R, Moresco, J J, Tu, P G, Aalto, A P, Pasquinelli, A E, Dillin, A G & Yates, J R 2014, ' Mass spectrometry-based shotgun proteomic analysis of C. elegans protein complexes ', WormBook: the online review of C. elegans biology, pp. 1-18 . https://doi.org/10.1895/wormbook.1.171.1

Mass spectrometry (MS)-based shotgun proteomics is an enabling technology for the study of C. elegans proteins. When coupled with co-immunoprecipitation (CoIP), new interactions and functions among proteins can be discovered. We provide a general bac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97da7a3cbef169a69a89c9d142a5c3b2
https://doi.org/10.1895/wormbook.1.171.1

Casein kinase II promotes target silencing by miRISC through direct phosphorylation of the DEAD-box RNA helicase CGH-1

Autor: Mallory A. Freeberg, Vishal Khivansara, John R. Yates, Xantha Karp, Eric Montoye, Patricia G. Tu, James J. Moresco, John Kim, Amelia F. Alessi, Ting Han

Publikováno v: Proceedings of the National Academy of Sciences. 112

Significance MicroRNAs (miRNAs) are critical regulators of diverse biological processes. Despite rapid advances in understanding miRNA biogenesis and function, a gap remains in our knowledge of how miRNA effector complex activity [miRNA-induced silen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a462c6536d2d878a8ca48bdb4c9632c2
https://doi.org/10.1073/pnas.1509499112

Overlapping and distinct functions of CstF64 and CstF64τ in mammalian mRNA 3′ processing

Autor: Patricia G. Tu, Xiaohui Xie, James J. Moresco, Yi Xing, Ji Wan, Yongsheng Shi, Eun-A Choi, John R. Yates, Chengguo Yao, Lingjie Weng

mRNA 3′ processing is dynamically regulated spatially and temporally. However, the underlying mechanisms remain poorly understood. CstF64τ is a paralog of the general mRNA 3′ processing factor, CstF64, and has been implicated in mediating testis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::360e16ed64f7f7102ef9b2538ee9e357
https://europepmc.org/articles/PMC3884657/

Plasma Membrane Proteomics of Human Breast Cancer Cell Lines Identifies Potential Targets for Breast Cancer Diagnosis and Treatment

Autor: Patricia G. Tu, Yvonne S. Ziegler, Ann M. Nardulli, John R. Yates, James J. Moresco

Publikováno v: PLoS ONE
PLoS ONE, Vol 9, Iss 7, p e102341 (2014)

The use of broad spectrum chemotherapeutic agents to treat breast cancer results in substantial and debilitating side effects, necessitating the development of targeted therapies to limit tumor proliferation and prevent metastasis. In recent years, t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75fa935ee28283a0610e0fb91e1bdd51
https://doi.org/10.1371/journal.pone.0102341