Výsledky vyhledávání - "Patricia E. Noker"

Evaluation of the Safety and Biodistribution of M032, an Attenuated Herpes Simplex Virus Type 1 Expressing hIL-12, After Intracerebral Administration toAotusNonhuman Primates

Autor: Justin C. Roth, G. Yancey Gillespie, Jackie N. Parker, James O. Peggins, Kathleen H. Price, Nicholas W. Powers, Jennifer M. Coleman, Steven L. Carroll, Richard J. Whitley, Sheila D. Grimes, James M. Markert, Kevin A. Cassady, Patricia E. Noker, James J. Cody

Publikováno v: Human Gene Therapy Clinical Development. 25:16-27

Herpes simplex virus type 1 (HSV-1) mutants lacking the γ(1)34.5 neurovirulence loci are promising agents for treating malignant glioma. Arming oncolytic HSV-1 to express immunostimulatory genes may potentiate therapeutic efficacy. We have previousl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56adca6f1005f8e637e1cfa3c10bd7ed
https://doi.org/10.1089/humc.2013.201

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Evaluation of hepatic and thyroid responses in male Sprague Dawley rats for up to eighty-four days following seven days of dietary exposure to potassium perfluorooctanesulfonate

Autor: Shu-Ching Chang, Patricia E. Noker, John L. Butenhoff, Clifford R. Elcombe, Barbara M. Elcombe, David J. Ehresman, John R. Foster

Publikováno v: Toxicology. 293:30-40

In a prior 28-day dietary study in rats with 20 and 100 ppm K⁺ PFOS, activation of PPARα and CAR/PXR were concluded to be etiological factors in K⁺ PFOS-induced hepatomegaly and hepatic tumorigenesis. The objective of this study was to evaluate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a8a85ee1ff82822e3ba48d132d84b78
https://doi.org/10.1016/j.tox.2011.12.015

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Preclinical pharmacokinetics, metabolism, and toxicity of azurin-p28 (NSC745104) a peptide inhibitor of p53 ubiquitination

Autor: Thomas L. Horn, Lori Coward, Patricia E. Noker, David L. McCormick, Gregory S. Gorman, Craig W. Beattie, Tapas K. Das Gupta, Bellur S. Prabhakar, Balaji B. Ganesh, J. Brooks Harder, Lee Jia, Miguel Muzzio

Publikováno v: Cancer Chemotherapy and Pharmacology. 68:513-524

Characterize the preclinical pharmacokinetics, metabolic profile, multi-species toxicology, and antitumor efficacy of azurin-p28 (NSC 745104), an amphipathic, 28 amino acid fragment (aa 50-77) of the copper containing redox protein azurin that prefer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::369363875fb7efa822178b5236c5dab6
https://doi.org/10.1007/s00280-010-1518-3

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Toxicology and pharmacokinetics of 1-methyl-d-tryptophan: Absence of toxicity due to saturating absorption

Autor: Karen Schweikart, John G. Page, Patricia E. Noker, David H. Munn, Joel M. Reid, Sarah A. Buhrow, Joseph E. Tomaszewski, Lee Jia, Matthew M. Ames

Publikováno v: Food and Chemical Toxicology. 46:203-211

1-methyl-d-tryptophan (D-1MT) reverses the immunosuppressive effect of indoleamine 2,3-dioxygenase (IDO), and it is currently being developed both as a vaccine adjuvant and as an immunotherapeutic agent for combination with chemotherapy. The present

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36d429dda04e69dcb4b9ccc4a2adf20c
https://doi.org/10.1016/j.fct.2007.07.017

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Interspecies pharmacokinetics and in vitro metabolism of SQ109

Autor: Lee Jia, Joseph E. Tomaszewski, Patricia E. Noker, Marina Protopopova, Gregory S. Gorman, Lori Coward

Publikováno v: British Journal of Pharmacology. 147:476-485

This study aimed at characterizing the interspecies absorption, distribution, metabolism and elimination (ADME) profile of N-geranyl-N'-(2-adamantyl)ethane-1,2-diamine (SQ109), a new diamine-based antitubercular drug. Single doses of SQ109 were admin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9681f66705fe01386fecdeea2cc1f80a
https://doi.org/10.1038/sj.bjp.0706650

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Increased antitumor activity, intratumor paclitaxel concentrations, and endothelial cell transport of cremophor-free, albumin-bound paclitaxel, ABI-007, compared with cremophor-based paclitaxel

Autor: Patrick Soon-Shiong, Vuong Trieu, Leslie Louie, Sherry Ci, Neil Desai, Andrew Yang, Bridget Beals, Rosie Yao, Chunlin Tao, Elizabeth Labao, Zhiwen Yao, Tapas De, Patricia E. Noker, Donald J. Dykes, Michael M. Hawkins

Publikováno v: Clinical Cancer Research. 12:1317-1324

ABI-007, an albumin-bound, 130-nm particle form of paclitaxel, was developed to avoid Cremophor/ethanol-associated toxicities in Cremophor-based paclitaxel (Taxol) and to exploit albumin receptor-mediated endothelial transport. We studied the antitum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fe0ad8dfadbbac9e1c1cb23dc8cae7d
https://doi.org/10.1158/1078-0432.ccr-05-1634

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Pharmacoproteomic Effects of Isoniazid, Ethambutol, andN-Geranyl-N′-(2-adamantyl)ethane-1,2-diamine (SQ109) onMycobacterium tuberculosisH37Rv

Autor: Patricia E. Noker, Lee Jia, Joseph E. Tomaszewski, Gregory S. Gorman, Lori Coward

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 315:905-911

The present study was aimed at fingerprinting pharmacoproteomic alterations of the Mycobacterium tuberculosis H37Rv strain induced by antitubercular drugs isoniazid (INH), ethambutol (EMB), and SQ109 [N-geranyl-N'-(2-adamantyl)ethane-1,2-diamine, a n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9ed829d083a5bc7e9725d1f47fb0bfa
https://doi.org/10.1124/jpet.105.087817

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Simultaneous estimation of pharmacokinetic properties in mice of three anti-tubercular ethambutol analogs obtained from combinatorial lead optimization

Autor: Elizabeth R. Glaze, Gregory S. Gorman, Patricia E. Noker, Marina Protopopova, Joseph E. Tomaszewski, Lee Jia

Publikováno v: Journal of Pharmaceutical and Biomedical Analysis. 37:793-799

Integrating combinatorial lead optimization of [1,2]-diamine core structure based on ethambutol with high-throughput screening has led us to focus on three promising analogs (SQ37, SQ59 and SQ109) as potential anti-tubercular drug candidates from tho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a10860a8aec869f47e60154baa30c74
https://doi.org/10.1016/j.jpba.2004.11.036

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Pharmacodynamics and pharmacokinetics of SQ109, a new diamine-based antitubercular drug

Autor: Patricia E. Noker, Joseph E. Tomaszewski, Marina Protopopova, Boris Nikonenko, Lee Jia, Gregory S. Gorman, Colleen F. Hanrahan, Lori Coward

Publikováno v: British Journal of Pharmacology. 144:80-87

SQ109 is a novel [1,2]-diamine-based ethambutol (EMB) analog developed from high-throughput combinatorial screening. The present study aimed at characterizing its pharmacodynamics and pharmacokinetics. The antimicrobial activity of SQ109 was confirme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ad18a995ce6c5ce23eba0e5e94388408
https://doi.org/10.1038/sj.bjp.0705984

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Toxicity of methylsulfonylmethane in rats

Autor: S. Somfai-Relle, R. Glavits, I. Financsek, Keith J. Horvath, Alexander G. Schauss, Patricia E. Noker

Publikováno v: Food and Chemical Toxicology. 40:1459-1462

Methylsulfonylmethane (MSM) is a popular dietary supplement used in a variety of conditions including pain, inflammation, allergies, arthritis, parasitic infections and the maintenance of normal keratin levels in hair, skin and nails. Despite its pop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6912fe6e872f3f398d44bb5db624dad6
https://doi.org/10.1016/s0278-6915(02)00086-8

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