Výsledky vyhledávání - "Patricia E. Levi"

Modulation of Mouse P450 Isoforms CYP1A2, CYP2B10, CYP2E1, and CYP3A by the Environmental Chemicals Mirex, 2,2-Bis(p-chlorophenyl)-1,1-dichloroethylene, Vinclozolin, and Flutamide

Autor: Randy L. Rose, Patricia E. Levi, T. Greg Falls, Ernest Hodgson, Yan Cao, Ding Dai

Publikováno v: Pesticide Biochemistry and Physiology. 70:127-141

Several environmental chemicals are disruptive to the reproductive and endocrine systems of many species, including humans. Mechanisms for endocrine disruption are presently under scrutiny. Xenobiotic inducible mammalian cytochrome P450 (CYP) enzymes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b0212cf5e37a3da7cae53f0fc37179ef
https://doi.org/10.1006/pest.2001.2551

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Molecular Cloning, Sequence, and Expression of Mouse Flavin-Containing Monooxygenases 1 and 5 (FMO1 and FMO5)

Autor: Randy L. Rose, Ernest Hodgson, Nathan J. Cherrington, Richard M. Philpot, Kieran M. Clements, Patricia E. Levi, J. Greg Falls

Publikováno v: Journal of Biochemical and Molecular Toxicology. 12:205-212

Full-length cDNA clones encoding FMO1 and FMO5 have been isolated from a library constructed with mRNA from the liver of a female CD-1 mouse. The derived sequence of FMO1 contains 2310 bases: 1596 in the coding region, 301 in the 5'-flanking region,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::839bb4aff7a4e522094b33df534e64e6
https://doi.org/10.1002/(sici)1099-0461(1998)12:4<205::aid-jbt2>3.0.co

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Purification and immunochemical detection of β-naphthoflavone-and phenobarbital-induced avian cytochrome P450 enzymes

Autor: Patricia E. Levi, Randal L. Brown, Mark J. Melancon, Ernest Hodgson

Publikováno v: Environmental Toxicology and Chemistry. 15:2293-2298

Livers from mallards (Anas platyrhynchos) were treated with either β-naphthoflavone (50 mg/kg) or phenobarbital (70 mg/kg). Purification of induced hepatic cytochrome P450 was accomplished using both DEAE and hydroxyapatite columns, as well as sodiu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::744d1f3a208a3e1865b917d62ca03416
https://doi.org/10.1002/etc.5620151226

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Gender differences in hepatic expression of flavin-containing monooxygenase isoforms (FMO1, FMO3, and FMO5) in Mice

Autor: Ernest Hodgson, J. Greg Falls, Patricia E. Levi, Bonnie L. Blake, Yan Cao

Publikováno v: Journal of Biochemical Toxicology. 10:171-177

Hepatic flavin-containing monooxygenase (FMO) activity of microsomes from adult CD-1, Swiss-Webster, C57BL/6, and DBA/2 mice was found to be significantly higher in females than in males. Based on protein and mRNA levels in CD-1 mice, FMO forms respo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a78bc3948730219f20955647237bd414
https://doi.org/10.1002/jbt.2570100308

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Differences in Induction of Three P450 Isozymes by Piperonyl Butoxide, Sesamex, Safrole, and Isosafrole

Autor: Patricia E. Levi, Nancy H. Adams, Ernest Hodgson

Publikováno v: Pesticide Biochemistry and Physiology. 46:15-26

The induction of the P450 isozymes 1a-1, 1a-2, and 2b-10 by four methylenedioxyphenyl (MDP) compounds, safrole (SAF), isosafrole (ISO), piperonyl butoxide (PBO), and sesamex (SES), and by the nonmethylenedioxyphenyl analog of SAF, allyl benzene (AB),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::690651ab6f0e78c53f3627bb1f840576
https://doi.org/10.1006/pest.1993.1032

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Regulation of cytochrome P-450 isozymes by methylenedioxyphenyl compounds

Autor: Ernest Hodgson, Nancy H. Adams, Patricia E. Levi

Publikováno v: Chemico-Biological Interactions. 86:255-274

Regulation of cytochrome P-450 isozymes 1a-1, 1a-2, and 2b-10 by methylenedioxyphenyl compounds was studied by measuring levels of mRNA, protein, and enzyme activity in hepatic tissue from C57BL/6 (Ah+) and DBA/2 (Ah-) mice dosed with isosafrole (ISO

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93c263e4ce3c97c396d0da2d6865c835
https://doi.org/10.1016/0009-2797(93)90101-4

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Induction of cytochrome P450 4A1 in mouse liver by the herbicide synergist tridiphane

Autor: Nancy H. Adams, Patricia E. Levi, Ernest Hodgson, Randy L. Rose

Publikováno v: Pesticide Biochemistry and Physiology. 44:9-14

The herbicide synergist tridiphane [2-(3,5-dichlorophenyl)-2-(2,2,2,-trichloroethyl) oxirane] was examined for its ability to induced cytochrome P450 in vivo. Male C57BL/6N mice were given tridiphane, 250 mg/kg ip, for 3 days. Liver weight and P450 c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f667f42f0cdd3c204e95b9ff28a222ff
https://doi.org/10.1016/0048-3575(92)90003-i

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Enzymatic and immunohistochemical studies on the role of cytochrome P450 and the flavin-containing monooxygenase of mouse skin in the metabolism of pesticides and other xenobiotics

Autor: Rama Misra, Ernest Hodgson, Alfred O. Inman, Nancy A. Monteiro-Riviere, Krishnappa Venkatesh, Patricia E. Levi

Publikováno v: Pesticide Biochemistry and Physiology. 43:53-66

The cytochrome P450 (P450) content, the cytochrome c reductase activity, the metabolism of a variety of P450 substrates, and the presence and role of flavin-containing monooxygenase (FMO) in xenobiotic metabolism were studied in skin microsomes and c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d38815db28bd852c51f2d60d43a16bb8
https://doi.org/10.1016/0048-3575(92)90019-v

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The flavin-containing monooxygenase of mouse kidney

Autor: Patricia E. Levi, Krishnappa Venkatesh, Ernest Hodgson

Publikováno v: Biochemical Pharmacology. 42:1411-1420

Flavin-containing monooxygenase (FMO; EC 1.14.13.8) was purified from mouse kidney microsomes and compared to that isolated from mouse liver microsomes. The purified enzymes from kidney and liver appeared as a single band on sodium dodecyi sulfate-po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9f80001e94d3e4a660c95c6645c9f5f2
https://doi.org/10.1016/0006-2952(91)90453-c

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