Zobrazeno 1 - 10
of 164
pro vyhledávání: '"Patricia E. Ganey"'
Autor:
Jeffrey F. Waring, Patricia E. Ganey, Robert A. Roth, Eric A. G. Blomme, David M. Nelson, Amy C. Ditewig, Jane F. Maddox, James P. Luyendyk, Lois D. Lehman-McKeeman, Vasanthi M. Bhaskaran, Michael J. Liguori
Publikováno v:
International Journal of Molecular Sciences, Vol 11, Iss 11, Pp 4697-4714 (2010)
Idiosyncratic drug reactions (IDRs) are poorly understood, unpredictable, and not detected in preclinical studies. Although the cause of these reactions is likely multi-factorial, one hypothesis is that an underlying inflammatory state lowers the tol
Externí odkaz:
https://doaj.org/article/cd16481e4a9f4fe5ad6ba562b8b8db9a
Publikováno v:
Expert opinion on drug metabolismtoxicology. 18(7-8)
Idiosyncratic drug-induced liver injury (IDILI) causes morbidity and mortality in patients and leads to curtailed use of efficacious pharmaceuticals. Unlike intrinsically toxic reactions, which depend on dose, IDILI occurs in a minority of patients a
Autor:
Robert A. Roth, Patricia E. Ganey
Publikováno v:
Expert Opin Drug Metab Toxicol
INTRODUCTION: Idiosyncratic, drug-induced liver injury (IDILI) continues to plague patients and restrict the use of drugs that are pharmacologically effective. Mechanisms of IDILI are incompletely understood, and a better understanding would reduce s
Autor:
Patricia E. Ganey, Kenneth L. Hastings, Martin D. Green, Robert A. Roth, Bin Gao, Gary R. Burleson
Publikováno v:
Int J Toxicol
The liver is primarily thought of as a metabolic organ; however, the liver is also an important mediator of immunological functions. Key perspectives on this emerging topic were presented in a symposium at the 2018 annual meeting of the American Coll
Publikováno v:
Chemico-biological interactions. 345
2,3,7,8-Tetrachlorodibenzo-p-dioxin (dioxin; TCDD) is an environmental contaminant that elicits a variety of toxic effects, many of which are mediated through activation of the aryl hydrocarbon receptor (AhR). Interaction between AhR and the peroxiso
Publikováno v:
Toxicological Sciences. 175:1-2
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 360:368-377
Idiosyncratic drug-induced liver injury continues to be a human health problem in part because drugs that cause these reactions are not identified in current preclinical testing and because progress in prevention is hampered by incomplete knowledge o
Autor:
Patricia E. Ganey, Sean A. Misek
Publikováno v:
Cellular Signal Transduction in Toxicology and Pharmacology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7c3026261659e726598909b60899d5f
https://doi.org/10.1002/9781119060208.ch4
https://doi.org/10.1002/9781119060208.ch4
Autor:
Patricia E. Ganey, Gurpreet Kaur, Ashley R. Maiuri, Sarah L. Hession, Anna B. Breier, Jonathan Turkus, Theresa A. Lansdell, Bronlyn Wassink, Robert A. Roth
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 362(3)
Idiosyncratic drug-induced liver injury (IDILI) typically occurs in a small fraction of patients and has resulted in removal of otherwise efficacious drugs from the market. Current preclinical testing methods are ineffective in predicting which drug
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 349:185-191
Trovafloxacin (TVX) is a fluoroquinolone antibiotic known to cause idiosyncratic, drug-induced liver injury (IDILI) in humans. The mechanism underlying this toxicity remains unknown. Previously, an animal model of IDILI in mice revealed that TVX syne