Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Patricia E Simms"'
Autor:
Stanley Borowicz, Daniel R Principe, Matthew J Dorman, Austin J McHenry, Gautam Sondarva, Sandeep Kumar, Vijayalakshmi Ananthanarayanan, Patricia E Simms, Ashley Hess, Ajay Rana
Publikováno v:
PLoS ONE, Vol 16, Iss 6, p e0252197 (2021)
Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide. Though immune checkpoint inhibitors (ICIs) have revolutionized lung cancer therapy in recent years, there are several factors limiting the therapeutic efficacy
Externí odkaz:
https://doaj.org/article/25fe873de866459c8a595831290f2495
Autor:
Gautam Sondarva, Ajay Rana, Vijayalakshmi Ananthanarayanan, Austin J. McHenry, Matthew J. Dorman, Patricia E. Simms, Stanley Borowicz, Sandeep Kumar, Daniel R. Principe, Ashley Hess
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 6, p e0252197 (2021)
PLoS ONE, Vol 16, Iss 6, p e0252197 (2021)
Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide. Though immune checkpoint inhibitors (ICIs) have revolutionized lung cancer therapy in recent years, there are several factors limiting the therapeutic efficacy
Autor:
Ines Pulido, Javier Alcácer, Javier Alcácer Fernández-Coronado, Julian Carretero, José M. Galbis-Caravajal, Kwok-Kin Wong, Patricia E. Simms, Jeffrey H. Becker, Paloma Martín-Martorell, Rutu Gandhi, Margaret Soucheray, Miguel Aupi, Aránzazu Lafuente-Sanchis, Amelia Insa, Agustín Lahoz, Ashley Hess, Fatima Al-Shahrour, Camilla L. Christensen, Michael P. Kahle, Yandi Gao, Jeffrey A. Borgia, Oscar Juan, Maria L. Rodriguez, Hajime Asahina, Antonio Cremades, Eiki Kikuchi, Pasi A. Jänne, Takeshi Shimamura
Publikováno v:
CANCER RESEARCH
r-FISABIO. Repositorio Institucional de Producción Científica
instname
r-FISABIO: Repositorio Institucional de Producción Científica
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
Cancer research, vol 79, iss 17
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
r-FISABIO. Repositorio Institucional de Producción Científica
instname
r-FISABIO: Repositorio Institucional de Producción Científica
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
Cancer research, vol 79, iss 17
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
Although EGFR mutant–selective tyrosine kinase inhibitors (TKI) are clinically effective, acquired resistance can occur by reactivating ERK. We show using in vitro models of acquired EGFR TKI resistance with a mesenchymal phenotype that CXCR7, an a
Autor:
Deep Shah, Clodia Osipo, Patricia E. Simms, Emad A. Rakha, Aleksandra Filipovic, Lucio Miele, Debra Wyatt, Andrew T. Baker, Daniel S. Peiffer, Michelle L. Fernandez, Andrew R. Green
Publikováno v:
Clinical Cancer Research. 24:4566-4578
Purpose: HER2-positive breast cancer is driven by cells possessing stem-like properties of self-renewal and differentiation, referred to as cancer stem cells (CSC). CSCs are implicated in radiotherapy, chemotherapy resistance, and tumor recurrence. N
Autor:
Yuan Wang, Lance M. Hellman, Thomas W. Smith, Brian M. Baker, Michael I. Nishimura, Timothy T. Spear, Patricia E. Simms, Elizabeth Garrett-Mayer
Publikováno v:
Molecular Therapy. 26:996-1007
The use of T cell receptor (TCR) gene-modified T cells in adoptive cell transfer has had promising clinical success, but often, simple preclinical evaluation does not necessarily accurately predict treatment efficacy or safety. Preclinical studies ge
Autor:
Priyanka Sharma, Chang-Sook Hong, Saigopalakrishna S. Yerneni, Michael Boyiadzis, Patricia E. Simms, Edwin K. Jackson, Theresa L. Whiteside
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Scientific Reports
Scientific Reports
Exosomes, small (30–150 nm) extracellular vesicles (EVs) isolated from plasma of patients with acute myeloid leukemia (AML) carry leukemia-associated antigens and multiple inhibitory molecules. Circulating exosomes can deliver suppressive cargos to
Autor:
Elizabeth Garrett-Mayer, Jeffrey J. Roszkowski, Glenda G. Callender, Timothy T. Spear, Michael I. Nishimura, Makio Iwashima, Yuan Wang, Patricia E. Simms, Kendra C. Foley, Lance M. Hellman, Rachel H. McMahan, Brian M. Baker, Gina Scurti, Timothy P. Riley, Gretchen E. Lyons, Hugo R. Rosen, David C. Murray
Publikováno v:
Journal of Leukocyte Biology. 100:545-557
A major obstacle hindering the development of effective immunity against viral infections, their associated disease, and certain cancers is their inherent genomic instability. Accumulation of mutations can alter processing and presentation of antigen
Autor:
Jeffrey J. Roszkowski, Michael I. Nishimura, Kendra C. Foley, Glenda G. Callender, Alexander Langerman, Timothy T. Spear, Mingli Li, Elizabeth Garrett-Mayer, Yi Zhang, Gina Scurti, Patricia E. Simms, David C. Murray, Justin T. Thomas, Kelly Moxley
Publikováno v:
Cancer Immunology, Immunotherapy. 65:293-304
The success in recent clinical trials using T cell receptor (TCR)-genetically engineered T cells to treat melanoma has encouraged the use of this approach toward other malignancies and viral infections. Although hepatitis C virus (HCV) infection is b
Publikováno v:
Journal of leukocyte biology. 102(2)
Advancement in flow cytometry reagents and instrumentation has allowed for simultaneous analysis of large numbers of lineage/functional immune cell markers. Highly complex datasets generated by polychromatic flow cytometry require proper analytical s
Autor:
Kendra C. Foley, Timothy T. Spear, Yuan Wang, Patricia E. Simms, Michael I. Nishimura, David C. Murray, Gina Scurti, Lance M. Hellman, Elizabeth Garrett-Mayer, Brian M. Baker
Publikováno v:
Cancer immunology, immunotherapy : CII. 66(11)
T-cell receptor (TCR)-pMHC affinity has been generally accepted to be the most important factor dictating antigen recognition in gene-modified T-cells. As such, there is great interest in optimizing TCR-based immunotherapies by enhancing TCR affinity