Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Patricia Deng"'
Autor:
Patricia Deng, Anzer Khan, Dionna Jacobson, Nagraj Sambrani, Leeanne McGurk, Xianghua Li, Aswathy Jayasree, Jan Hejatko, Galit Shohat-Ophir, Mary A. O’Connell, Jin Billy Li, Liam P. Keegan
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Human RNA editing enzymes ADAR1 and ADAR2 are required for innate immune functions and neurological functions, respectively. Here, the authors show that Drosophila Adar has both innate immune and brain functions, despite being the homolog of mammalia
Externí odkaz:
https://doaj.org/article/f2300f5bbdf84bf08236658c6672b294
Publikováno v:
Cell Reports, Vol 11, Iss 5, Pp 697-703 (2015)
Adenosine-to-inosine RNA editing modifies maturing mRNAs through the binding of adenosine deaminase acting on RNA (Adar) proteins to double-stranded RNA structures in a process critical for neuronal function. Editing levels at individual editing site
Externí odkaz:
https://doaj.org/article/1a3c579861f1406d9038b810d5fa8ead
Publikováno v:
PLoS Genetics, Vol 13, Iss 11, p e1007064 (2017)
Adenosine-to-inosine (A-to-I) RNA editing is an important post-transcriptional modification that affects the information encoded from DNA to RNA to protein. RNA editing can generate a multitude of transcript isoforms and can potentially be used to op
Externí odkaz:
https://doaj.org/article/a653e0b2729244468d1756f6370d149c
Publikováno v:
PLoS Genetics, Vol 13, Iss 2, p e1006563 (2017)
Adenosine-to-inosine RNA editing diversifies the transcriptome and promotes functional diversity, particularly in the brain. A plethora of editing sites has been recently identified; however, how they are selected and regulated and which are function
Externí odkaz:
https://doaj.org/article/f74b02b325ae4325bf4dd2852ec49a64
Autor:
Xingjie Ren, Zhihao Yang, Jiang Xu, Jin Sun, Decai Mao, Yanhui Hu, Su-Juan Yang, Huan-Huan Qiao, Xia Wang, Qun Hu, Patricia Deng, Lu-Ping Liu, Jun-Yuan Ji, Jin Billy Li, Jian-Quan Ni
Publikováno v:
Cell Reports, Vol 9, Iss 3, Pp 1151-1162 (2014)
The CRISPR/Cas9 system has recently emerged as a powerful tool for functional genomic studies in Drosophila melanogaster. However, single-guide RNA (sgRNA) parameters affecting the specificity and efficiency of the system in flies are still not clear
Externí odkaz:
https://doaj.org/article/bbc65e452c5845fd9aa65c82ab6282a1
Autor:
Anzer Khan, Patricia Deng, Xianghua Li, Leeanne McGurk, Liam Keegan, Galit Shohat-Ophir, Jan Hejátko, Mary A. O’Connell, Nagraj Sambrani, Jin Billy Li, Aswathy Jayasree, Dionna Jacobson
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
ADAR RNA editing enzymes are high-affinity dsRNA-binding proteins that deaminate adenosines to inosines in pre-mRNA hairpins and also exert editing-independent effects. We generated a Drosophila AdarE374A mutant strain encoding a catalytically inacti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::410adc673d91b3f3f9286920984b07db
Publikováno v:
Cell Reports, Vol 11, Iss 5, Pp 697-703 (2015)
SUMMARY Adenosine-to-inosine RNA editing modifies maturing mRNAs through the binding of adenosine deaminase acting on RNA (Adar) proteins to double-stranded RNA structures in a process critical for neuronal function. Editing levels at individual edit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1ddf4d1559b5b30ab907cb2f263ba4a
http://www.sciencedirect.com/science/article/pii/S2211124715003800
http://www.sciencedirect.com/science/article/pii/S2211124715003800
Autor:
Rui Zhang, Gokul Ramaswami, Patricia Deng, Jin Billy Li, Robert Piskol, Mary A O'Connell, Liam Keegan
Publikováno v:
Ramaswami, G, Zhang, R, Piskol, R, Keegan, L P, Deng, P, O'Connell, M A & Li, J B 2013, ' Identifying RNA editing sites using RNA sequencing data alone ', Nature Methods, vol. 10, no. 2, pp. 128-32 . https://doi.org/10.1038/nmeth.2330
We show that RNA editing sites can be called with high confidence using RNA sequencing data from multiple samples across either individuals or species, without the need for matched genomic DNA sequence. We identified many previously unidentified edit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e9985ea3b7ccd1f5a79cd9c91841698
https://doi.org/10.1038/nmeth.2330
https://doi.org/10.1038/nmeth.2330
Autor:
Jin Billy Li, Mary Anna Carbone, Trudy F. C. Mackay, Patricia Deng, Gokul Ramaswami, Rui Zhang
Publikováno v:
Nature Communications
Adenosine-to-inosine (A-to-I) RNA editing, catalysed by ADAR enzymes conserved in metazoans, plays an important role in neurological functions. Although the fine-tuning mechanism provided by A-to-I RNA editing is important, the underlying rules gover
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b263f77c318becc2959d5f60d9005f7d
https://doi.org/10.1038/ncomms9194
https://doi.org/10.1038/ncomms9194
Publikováno v:
Lorenz, S; Deng, P; Hantschel, O; Superti-Furga, G; & Kuriyan, J. (2015). Crystal structure of an SH2-kinase construct of c-Abl and effect of the SH2 domain on kinase activity. Biochemical Journal, 468(2), 283-291. doi: 10.1042/BJ20141492. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/86p8q99t
Europe PubMed Central
The Biochemical journal, vol 468, iss 2
Europe PubMed Central
The Biochemical journal, vol 468, iss 2
© 2015 Biochemical Society. Constitutive activation of the non-receptor tyrosine kinase c-Abl (cellular Abelson tyrosine protein kinase 1, Abl1) in the Bcr (breakpoint cluster region)-Abl1 fusion oncoprotein is the molecular cause of chronic myeloid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1fa2667da878df9ede29f81883267d3
https://pubmed.ncbi.nlm.nih.gov/25779001
https://pubmed.ncbi.nlm.nih.gov/25779001