Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Patricia Darcy"'
Autor:
Graham Buckton, Patricia Darcy
Publikováno v:
Thermochimica Acta. 316:29-36
Isothermal microcalorimetry is used to study small quantities of amorphous materials in crystalline powders. The aim of this work is to better understand the isothermal microcalorimetry measurement with regard to the quantification of amorphous conte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a3b0a979b26d723b7441f070753c148
https://doi.org/10.1016/s0040-6031(98)00300-1
https://doi.org/10.1016/s0040-6031(98)00300-1
Autor:
Graham Buckton, Patricia Darcy
Publikováno v:
International Journal of Pharmaceutics. 158:157-164
This study was designed to investigate the influence of collapse of amorphous lactose on its subsequent behaviour during drying, or other processes which cause increases in the temperature of the material. Amorphous lactose was prepared by spray dryi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f4f0d99946d06615fe9dd9af24c8489
https://doi.org/10.1016/s0378-5173(97)00245-7
https://doi.org/10.1016/s0378-5173(97)00245-7
Autor:
Patricia Darcy, Graham Buckton
Publikováno v:
International Journal of Pharmaceutics. 136:141-146
The water sorption behaviour of amorphous lactose has been investigated gravimetrically. It was found that the kinetics of absorption at (especially) 40% and (also) 50% RH were bi-phasic. Although we have no explanation for this behaviour, it is note
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a27e3803419f1ede60e22b7ac93aeee2
https://doi.org/10.1016/0378-5173(96)04503-6
https://doi.org/10.1016/0378-5173(96)04503-6
Autor:
Graham Buckton, Patricia Darcy
Publikováno v:
International Journal of Pharmaceutics. 123:265-271
An accurate humidity and temperature controlled microbalance system (dynamic vapour sorption) has been used to investigate the water sorption properties of mixtures of amorphous lactose (spray dried) and crystalline a-lactose monohydrate. From the sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b742be5e018a902acd35b5d8f1a10fc
https://doi.org/10.1016/0378-5173(95)00083-u
https://doi.org/10.1016/0378-5173(95)00083-u
Autor:
Patricia Darcy, Graham Buckton
Publikováno v:
International Journal of Pharmaceutics. 121:81-87
Amorphous material in crystals can constitute reactive ‘hot spots’, which can be centres for chemical degradation or physical transitions, leading to product instability. Problems have been encountered in studying small amounts of amorphous conte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::caf961e57ba4a7674e937547b81c1329
https://doi.org/10.1016/0378-5173(95)00009-8
https://doi.org/10.1016/0378-5173(95)00009-8
The use of isothermal microcalorimetry in the study of small degrees of amorphous content of powders
Publikováno v:
International Journal of Pharmaceutics. 117:253-256
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d40dec86fbe362a4a2961ef2ae7ffc1a
https://doi.org/10.1016/0378-5173(94)00421-z
https://doi.org/10.1016/0378-5173(94)00421-z
Publikováno v:
Colloids and Surfaces A: Physicochemical and Engineering Aspects. 95:27-35
Assessment of the wettability of powders is known to be problematic. It is known that the use of sessile drops on liquid saturated powder compacts can tend to underestimate the value of contact angle. The use of compacted plates of powder in a Wilhel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62983881d3e3208a70f039c75b737333
https://doi.org/10.1016/0927-7757(94)03001-g
https://doi.org/10.1016/0927-7757(94)03001-g
Publikováno v:
International Journal of Pharmaceutics. 105:125-135
Isothermal microcalorimetry has been used to follow recrystallisation of amorphous regions of powder surfaces. Lactose monohydrate was taken as a model powder, and was processed by spray drying and micronisation. Spray drying produced an amorphous po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d68dbb82442d1650ccf2a5dbfb63fde
https://doi.org/10.1016/0378-5173(94)90458-8
https://doi.org/10.1016/0378-5173(94)90458-8
Autor:
Phil C. Gordge, Patricia Darcy, W. Jonathan Ryves, N. M. Hassan, Fred J. Evans, A. Tudor Evans
Publikováno v:
Phytotherapy Research. 8:362-364
There has recently been considerable interest concerning the biochemical and pharmacological mechanisms of action of resiniferatoxin (Rx). Rx is a daphnane diterpene ester, which is part of the phorbol ester family of diterpenes. We have synthesized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a3d738ef2f6babf1fdd94ce9abc37d6
https://doi.org/10.1002/ptr.2650080610
https://doi.org/10.1002/ptr.2650080610