Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Patricia D. Murphy"'
Autor:
Patricia D. Murphy, Rachel T. Klein, Kathleen S. Hruska, E Sutcliffe, Anna K. McGill, KJ Vogel Postula
Publikováno v:
Cancer Research. 79:P5-09
Background: PARP inhibitors (PARPi) are FDA approved for a subset of metastatic human epidermal growth factor receptor 2-negative (H2N) breast cancer patients who harbor a germline pathogenic or likely pathogenic variant (PV) in BRCA1/2, two of the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed247ad76a0da88f6af0b186d062cc1e
https://doi.org/10.1158/1538-7445.sabcs18-p5-09-08
https://doi.org/10.1158/1538-7445.sabcs18-p5-09-08
Autor:
Kevin J. Arvai, Erin G. Sutcliffe, Lisa R. Susswein, Amy R. Stettner, Sheila R. Solomon, Patricia D. Murphy, Maegan E. Roberts, Kathleen S. Hruska, Rachel T. Klein, Megan L. Marshall, Stacey A. Miller
Publikováno v:
Cancer genetics.
Purpose Although CHEK2 is a well-established cancer gene, questions remain including whether risks vary substantially between different variants and whether biallelic carriers have higher risks than heterozygotes. We report on a cohort of individuals
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f7f30e55fd27e61a648598f0318a892
https://pubmed.ncbi.nlm.nih.gov/32805687
https://pubmed.ncbi.nlm.nih.gov/32805687
Abstract PD7-11: The role of multi-gene hereditary cancer panels in male patients with breast cancer
Autor:
Anna K. McGill, KJ Vogel Postula, Rachel T. Klein, K Theobald, E Sutcliffe, Kathleen S. Hruska, Patricia D. Murphy, Kevin J. Arvai, LM Andolina
Publikováno v:
Cancer Research. 78:PD7-11
Background/Statement of Purpose: The role of cancer susceptibility genes in the male breast cancer population beyond BRCA1 and BRCA2 (BRCA) is not well defined. While breast cancer has been documented in men with pathogenic variants in a number of ot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::511f3767a7fb2598a2d3ea36cfacb676
https://doi.org/10.1158/1538-7445.sabcs17-pd7-11
https://doi.org/10.1158/1538-7445.sabcs17-pd7-11
Autor:
Rachel T. Klein, Lance Grau, Kristen J. Vogel Postula, Lisa R. Susswein, Patricia D. Murphy, Megan L. Marshall, Susan Hiraki
Publikováno v:
Journal of Urology. 201
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39de2fc6ddd3d60ed24f80005aac1547
https://doi.org/10.1097/01.ju.0000556339.32452.db
https://doi.org/10.1097/01.ju.0000556339.32452.db
Autor:
Zhixiong Xu, Natalie J. Carter, Kathleen S. Hruska, Susan Hiraki, Rachel T. Klein, Kevin J. Arvai, Lisa R. Susswein, Rebecca I. Torene, Kristin K. Zorn, Megan L. Marshall, Lauren Yackowski, Anna K. McGill, Patricia D. Murphy, Benjamin D. Solomon
Publikováno v:
Gynecologic oncology. 151(3)
The recognition of genes implicated in ovarian cancer risk beyond BRCA1, BRCA2, and the Lynch syndrome genes has increased the variety of testing options available to providers and patients. We report the frequency of pathogenic variants identified a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b83ff799b0ce1fb5f5adb68407e7b684
https://pubmed.ncbi.nlm.nih.gov/30322717
https://pubmed.ncbi.nlm.nih.gov/30322717
Autor:
Rachel Nusbaum, Megan L. Marshall, Lauren Yackowski, Lisa R. Susswein, Scott M. Weissman, Kristen J. Vogel Postula, Patricia D. Murphy, Gabi Richard, Jeffrey Bissonnette, Erica M. Vaccari, Wendy K. Chung, Daniel E. Pineda-Alvarez, Jessica K. Booker, Sherri J. Bale, M. Laura Cremona, Rachel T. Klein, Guido D. Pollevick, Zhixiong Xu, Kathleen S. Hruska, Federica Gibellini
Publikováno v:
Genetics in Medicine
Purpose: Germ-line testing for panels of cancer genes using next-generation sequencing is becoming more common in clinical care. We report our experience as a clinical laboratory testing both well-established, high-risk cancer genes (e.g., BRCA1/2, M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54513942055a87a6c0069e6fe9baf282
http://europepmc.org/articles/PMC4985612
http://europepmc.org/articles/PMC4985612
Autor:
Jessica K. Booker, Lauren Yackowski, Erica M. Vaccari, Maria L Cremona, Melanie Hussong, Kathleen S. Hruska, Patricia D. Murphy
Publikováno v:
Cancer Research. 75:P4-12
Background: Hereditary breast and ovarian cancer (HBOC) is a common indication for referral to cancer genetic counselors. Next generation sequencing panels allow for the efficient evaluation of many genes associated with increased risk of these cance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ff5258947d57d07304cbf43058620ab
https://doi.org/10.1158/1538-7445.sabcs14-p4-12-01
https://doi.org/10.1158/1538-7445.sabcs14-p4-12-01
Autor:
Windy Berkofsky-Fessler, Constance Murphy, Deborah Pencarinha, Jessica K. Booker, Rebecca Yee Bassett, Haiyan Wan, Mingjuan Liao, Melanie Hussong, Nina Sanapareddy, Elisabeth McKeen, Kathleen S. Hruska, Patricia D. Murphy, Rachel Nusbaum, Erica S. Rinella, Rachel T. Klein, Zhixiong Xu, Joaquin Villar, Lisa R. Susswein, Maria L Cremona
Publikováno v:
Cancer Research. 75:P4-12
Introduction: Expansion of genetic testing technologies has brought multi-gene panels for cancer susceptibility into the clinic; however, the clinical utility of these next-generation sequencing (NGS) panels is largely unknown. Hypothesis: We hypothe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e2b9d08ab3081576ea5b46673fb7fa3
https://doi.org/10.1158/1538-7445.sabcs14-p4-12-05
https://doi.org/10.1158/1538-7445.sabcs14-p4-12-05
Publikováno v:
Science. 278:602-605
As increasing numbers of genes are identified and associated with human diseases, researchers are considering how to bring their discoveries from the research bench to the clinic. Holtzman, Murphy, Watson, and Barr, who were part of a Task Force on G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0bf1edf26e677dec673841900627207a
https://doi.org/10.1126/science.278.5338.602
https://doi.org/10.1126/science.278.5338.602
Autor:
David Burke, Eric L. Logigian, Joseph R. Madesen, Ernest W. Johnson, Peter J. Goadsby, S. E. Kaba, P. Pullicino, L. D. Jacobs, Michael A. Boss, Uma Ananth, Darcy Paquet, Patricia D. Murphy, Lynette Kiers
Publikováno v:
Muscle & Nerve. 18:126-130
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a19001f56154176d3bb0ccfaf3b78a3
https://doi.org/10.1002/mus.880180121
https://doi.org/10.1002/mus.880180121