Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Patricia Cogram"'
Autor:
Guido Zampieri, Léa Cabrol, Claudio Urra, Eduardo Castro-Nallar, Guillaume Schwob, David Cleary, Claudio Angione, Robert M.J. Deacon, Michael J. Hurley, Patricia Cogram
Publikováno v:
iScience, Vol 27, Iss 8, Pp 110348- (2024)
Summary: Gut microbiome dysbiosis is linked to many neurological disorders including Alzheimer’s disease (AD). A major risk factor for AD is polymorphism in the apolipoprotein E (APOE) gene, which affects gut microbiome composition. To explore the
Externí odkaz:
https://doaj.org/article/3ead3a48f0324c65bdd364cd48e987ab
Autor:
B. Maximiliano Garduño, Patrick Hanni, Chelsea Hays, Patricia Cogram, Nathan Insel, Xiangmin Xu
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
Maturation of the forebrain involves transitions from higher to lower levels of synaptic plasticity. The timecourse of these changes likely differs between regions, with the stabilization of some networks scaffolding the development of others. To gai
Externí odkaz:
https://doaj.org/article/4bd228a66edc492eb6bf2d06b11e2f6e
Autor:
Zhiqun Tan, B. Maximiliano Garduño, Pedro Fernández Aburto, Lujia Chen, Nicole Ha, Patricia Cogram, Todd C. Holmes, Xiangmin Xu
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-23 (2022)
Abstract The long-lived Chilean rodent (Octodon degus) has been reported to show spontaneous age-dependent neuropathology and cognitive impairments similar to those observed in human AD. However, the handful of published papers on degus of differing
Externí odkaz:
https://doaj.org/article/3a9886ab7b724ed1abd9fc6cda0f43e4
Autor:
Matias Mugnaini, Diana Polania, Yannina Diaz, Marcelo Ezquer, Fernando Ezquer, Robert M. J. Deacon, Patricia Cogram, Emilio Kropff
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract The Octodon degus is a South American rodent that is receiving increased attention as a potential model of aging and sporadic late-onset Alzheimer’s disease (AD). Impairments in spatial memory tasks in Octodon degus have been reported in r
Externí odkaz:
https://doaj.org/article/495e7d45e4dc417c892dacd7bb1a3553
Autor:
Patricia Cogram, Luis C. Fernández-Beltrán, María José Casarejos, Sonia Sánchez-Yepes, Eulalia Rodríguez-Martín, Alfonso García-Rubia, María José Sánchez-Barrena, Carmen Gil, Ana Martínez, Alicia Mansilla
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Fragile X syndrome (FXS) is caused by the loss of function of Fragile X mental retardation protein (FMRP). FXS is one of the leading monogenic causes of intellectual disability (ID) and autism. Although it is caused by the failure of a single gene, F
Externí odkaz:
https://doaj.org/article/5be53579afca493db46daa91c8c05468
Autor:
Samantha T. Reyes, Robert M. J. Deacon, Scarlett G. Guo, Francisco J. Altimiras, Jessa B. Castillo, Berend van der Wildt, Aimara P. Morales, Jun Hyung Park, Daniel Klamer, Jarrett Rosenberg, Lindsay M. Oberman, Nell Rebowe, Jeffrey Sprouse, Christopher U. Missling, Christopher R. McCurdy, Patricia Cogram, Walter E. Kaufmann, Frederick T. Chin
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Fragile X syndrome (FXS), a disorder of synaptic development and function, is the most prevalent genetic form of intellectual disability and autism spectrum disorder. FXS mouse models display clinically-relevant phenotypes, such as increased
Externí odkaz:
https://doaj.org/article/3fe726770d9a49e4a8f47d5b5a43daca
Autor:
Michael J. Hurley, Claudio Urra, B. Maximiliano Garduno, Agostino Bruno, Allison Kimbell, Brent Wilkinson, Cristina Marino-Buslje, Marcelo Ezquer, Fernando Ezquer, Pedro F. Aburto, Elie Poulin, Rodrigo A. Vasquez, Robert Deacon, Ariel Avila, Francisco Altimiras, Peter Whitney Vanderklish, Guido Zampieri, Claudio Angione, Gabriele Constantino, Todd C. Holmes, Marcelo P. Coba, Xiangmin Xu, Patricia Cogram
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
The degu (Octodon degus) is a diurnal long-lived rodent that can spontaneously develop molecular and behavioral changes that mirror those seen in human aging. With age some degu, but not all individuals, develop cognitive decline and brain pathology
Externí odkaz:
https://doaj.org/article/e09a35f5fb5646e3af0bc630bdc8e841
Autor:
Patricia Cogram, Daniel L. Alkon, David Crockford, Robert M. J. Deacon, Michael J. Hurley, Francisco Altimiras, Miao-Kun Sun, Michael Tranfaglia
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Abstract Fragile X syndrome (FXS), an X-chromosome linked intellectual disability, is the leading monogenetic cause of autism spectrum disorder (ASD), a neurodevelopmental condition that currently has no specific drug treatment. Building upon the dem
Externí odkaz:
https://doaj.org/article/00287d6d1cc84304aef691c3d36f1b59
Autor:
Francisco Altimiras, José Antonio Garcia, Ismael Palacios-García, Michael J. Hurley, Robert Deacon, Bernardo González, Patricia Cogram
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
The human gut microbiome is the ecosystem of microorganisms that live in the human digestive system. Several studies have related gut microbiome variants to metabolic, immune and nervous system disorders. Fragile X syndrome (FXS) is a neurodevelopmen
Externí odkaz:
https://doaj.org/article/c4d87bb5ad8d4dfbb30a9233a5968f1e
Autor:
Patricia Cogram, Robert M. J. Deacon, Jennifer L. Warner-Schmidt, Melanie J. von Schimmelmann, Brett S. Abrahams, Matthew J. During
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 13 (2019)
Fragile X syndrome (FXS) is the most common inherited form of intellectual disability and autism. FXS is also accompanied by attention problems, hyperactivity, anxiety, aggression, poor sleep, repetitive behaviors, and self-injury. Recent work suppor
Externí odkaz:
https://doaj.org/article/5557ad91553a46b1a65dbc4a6e653b6a