Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Patricia Cobo-Stark"'
Autor:
Ronak Lakhia, Harini Ramalingam, Chun-Mien Chang, Patricia Cobo-Stark, Laurence Biggers, Andrea Flaten, Jesus Alvarez, Tania Valencia, Darren P. Wallace, Edmund C. Lee, Vishal Patel
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
ADPKD, a common aetiology of kidney failure, is caused by heterozygous PKD1 or PKD2 mutations. Here the authors show that preventing 3′-UTR cis-inhibition of mRNAs produced by the non-inactivated PKD1/2 alleles ameliorates preclinical ADPKD.
Externí odkaz:
https://doaj.org/article/5c3d27a136564233923d3e2f24e558f2
Autor:
Laurence Biggers, Venakt Malladi, Patricia Cobo-Stark, Ronak Lakhia, Sachin Hajarnis, Abheepsa Mishra, Vishal Patel
Widespread aberrant gene expression is pathological hallmark of polycystic kidney disease (PKD). Numerous pathogenic signaling cascades, including c-Myc, Fos, and Jun are transactivated. However, the underlying epigenetic regulators are poorly define
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eccc416f7031370e17f6387242e8c124
https://doi.org/10.1101/2021.11.19.469306
https://doi.org/10.1101/2021.11.19.469306
Autor:
Harini, Ramalingam, Sonu, Kashyap, Patricia, Cobo-Stark, Andrea, Flaten, Chun-Mien, Chang, Sachin, Hajarnis, Kyaw Zaw, Hein, Jorgo, Lika, Gina M, Warner, Jair M, Espindola-Netto, Ashwani, Kumar, Mohammed, Kanchwala, Chao, Xing, Eduardo N, Chini, Vishal, Patel
Publikováno v:
Cell metabolism. 33(6)
Autosomal dominant polycystic kidney disease (ADPKD) is a common monogenic disorder marked by numerous progressively enlarging kidney cysts. Mettl3, a methyltransferase that catalyzes the abundant N
Autor:
Sonu Kashyap, Chao Xing, Patricia Cobo-Stark, Jorgo Lika, Sachin Hajarnis, Harini Ramalingam, Kyaw Zaw Hein, Gina M. Warner, Mohammed Kanchwala, Eduardo N. Chini, Ashwani Kumar, Vishal Patel, Jair Machado Espindola-Netto, Chun Mien Chang, Andrea Flaten
Publikováno v:
Cell Metabolism. 33:1234-1247.e7
Summary Autosomal dominant polycystic kidney disease (ADPKD) is a common monogenic disorder marked by numerous progressively enlarging kidney cysts. Mettl3, a methyltransferase that catalyzes the abundant N6-methyladenosine (m6A) RNA modification, is
Autor:
Daniel G. Bichet, Shayan Farahani, Karam Aboudehen, Patricia Cobo-Stark, Lama Noureddine, Peter Igarashi, Micah D. Gearhart, Svetlana Avdulov, Marco Pontoglio, Vishal Patel
Publikováno v:
Journal of the American Society of Nephrology. 28:2887-2900
The transcription factor hepatocyte nuclear factor-1β (HNF-1β) is essential for normal kidney development and function. Inactivation of HNF-1β in mouse kidney tubules leads to early-onset cyst formation and postnatal lethality. Here, we used Pkhd1
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Autosomal dominant polycystic kidney disease (ADPKD) is the leading genetic cause of renal failure. We have recently shown that inhibiting miR-17~92 is a potential novel therapeutic approach for ADPKD. However, miR-17~92 is a polycistronic cluster th
Publikováno v:
Kidney international. 93(2)
Cyclic AMP promotes cyst growth in polycystic kidney disease (PKD) by stimulating cell proliferation and fluid secretion. Previously, we showed that the primary cilium of renal epithelial cells contains a cAMP regulatory complex comprising adenylyl c
Autor:
Karam, Aboudehen, Lama, Noureddine, Patricia, Cobo-Stark, Svetlana, Avdulov, Shayan, Farahani, Micah D, Gearhart, Daniel G, Bichet, Marco, Pontoglio, Vishal, Patel, Peter, Igarashi
Publikováno v:
Journal of the American Society of Nephrology : JASN. 28(10)
The transcription factor hepatocyte nuclear factor–1β (HNF-1β) is essential for normal kidney development and function. Inactivation of HNF-1β in mouse kidney tubules leads to early-onset cyst formation and postnatal lethality. Here, we used Pkh
Autor:
Osamu Nakagawa, Peter Igarashi, Patricia Cobo-Stark, Hiroki Kurihara, Qin Chen, Tomokazu Amano, Yukiko Kurihara, Masao Murakami, Yasunobu Uchijima, Koichi Nishiyama, Ryosuke Makita, Yutaka Yatomi, Hiroyuki Aburatani, Junji Tominaga, Takahiro Sato, Akihisa Mitani, Takahide Nagase, Erin V. Small, Takumi Takeuchi, Tomoichiro Asano
Publikováno v:
American Journal of Physiology-Renal Physiology. 294:F542-F553
TAZ (transcriptional coactivator with PDZ-binding motif), also called WWTR1 (WW domain containing transcription regulator 1), is a 14-3-3-binding molecule homologous to Yes-associated protein. TAZ acts as a coactivator for several transcription facto
Autor:
Vishal Patel, Massimo Attanasio, Peter Igarashi, Karam Aboudehen, Patricia Cobo-Stark, Sachin Hajarnis, Marco Pontoglio
The transcription factor hepatocyte nuclear factor-1β (HNF-1β) regulates tissue-specific gene expression in the kidney and other epithelial organs. Mutations of HNF-1β produce kidney cysts, and previous studies have shown that HNF-1β regulates th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2575225ac442185f14c149329fa6c3b
https://europepmc.org/articles/PMC4598991/
https://europepmc.org/articles/PMC4598991/