Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Patricia Caspar"'
Autor:
Alan Sher, Carl G. Feng, Sara Hieny, Siamon Gordon, Sandy Oland, Patricia Caspar, Bruno B. Andrade, Daniel L. Barber, Katrin D. Mayer-Barber
Publikováno v:
Immunity. 35(6):1023-1034
Interleukin-1 (IL-1) receptor signaling is required for control of Mycobacterium tuberculosis (Mtb) infection, yet the role of its two ligands, IL-1α and IL-1β, and the regulation of their expression in vivo are poorly understood. Here we show that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d540c0220c0b109933b583e70b4d1b6
Autor:
Alan Sher, Daniel L. Barber, Mark S. Wilson, Patricia Caspar, Richard A. Flavell, Dirk Schlueter, Fayyaz S. Sutterwala, Kevin Shenderov, Sara Hieny, Gabriel Núñez, David G. Kugler, Katrin D. Mayer-Barber, Sandra White, Allen W. Cheever
Publikováno v:
The Journal of Immunology. 184:3326-3330
To investigate the respective contributions of TLR versus IL-1R mediated signals in MyD88 dependent control of Mycobacterium tuberculosis, we compared the outcome of M. tuberculosis infection in MyD88, TRIF/MyD88, IL-1R1, and IL-1β–deficient mice.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1263b4f2a4bbc450ba6fb7a17901f074
https://doi.org/10.4049/jimmunol.0904189
https://doi.org/10.4049/jimmunol.0904189
Autor:
Lixin Zheng, Alan Sher, Jennifer L. Cannons, Dragana Jankovic, Damien Chaussabel, Pamela L. Schwartzberg, Patricia Caspar, Wendy T. Watford, Michael J. Lenardo, Carl G. Feng, Sara Hieny, André Báfica
Publikováno v:
Nature Immunology. 9:1279-1287
Mice deficient in the interferon-gamma (IFN-gamma)-inducible, immunity-related GTPase Irgm1 have defective host resistance to a variety of intracellular pathogens. This greater susceptibility to infection is associated with impaired IFN-gamma-depende
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8940da564e4ad8eb0a8cadce5b24d6d9
https://doi.org/10.1038/ni.1653
https://doi.org/10.1038/ni.1653
Autor:
Alan Sher, Patricia Caspar, Charles A. Scanga, Carl G. Feng, George S. Yap, Allen W. Cheever, Sara Hieny, Dragana Jankovic, Marika C. Kullberg
Publikováno v:
The Journal of Immunology. 174:4185-4192
The mechanisms that prevent reactivation of latent Mycobacterium tuberculosis infection in asymptomatic individuals are poorly understood. Although IL-12 is critical for the induction of IFN-γ-dependent host control of M. tuberculosis, the requireme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77ebeb83a78a6998d31f15c3c2a0ec14
https://doi.org/10.4049/jimmunol.174.7.4185
https://doi.org/10.4049/jimmunol.174.7.4185
Autor:
Marika C. Kullberg, Peter L. Gorelick, James G. Fox, Alan Sher, Patricia Caspar, Allen W. Cheever, John F. Andersen, Dragana Jankovic, Sebastian Suerbaum
Publikováno v:
Proceedings of the National Academy of Sciences. 100:15830-15835
It is now well established that the intestinal flora plays an important role in the pathogenesis of inflammatory bowel disease (IBD). However, whether bacteria serve as the sole target of the immune response in this process or whether they act indire
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94941fbe42297ecd2e51b577e7cf9f31
https://doi.org/10.1073/pnas.2534546100
https://doi.org/10.1073/pnas.2534546100
Autor:
Alan Sher, Dragana Jankovic, Patricia Caspar, Carl G. Feng, Robert L. Coffman, Allen W. Cheever, Marika C. Kullberg
Publikováno v:
Infection and Immunity. 70:6672-6679
Interleukin-10 (IL-10) is thought to play an important role in the regulation of microbial immunity. While T-cell-derived IL-10 has been shown to suppress cell-mediated immunity, there has been debate as to whether antigen presenting cell (APC)-deriv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7971fd440735e2c7ac7532153eb0be4
https://doi.org/10.1128/iai.70.12.6672-6679.2002
https://doi.org/10.1128/iai.70.12.6672-6679.2002
Autor:
Alan Sher, Carmen M. Collazo, Patricia Caspar, Carl G. Feng, Sara Hieny, George S. Yap, Gregory A. Taylor
Publikováno v:
Infection and Immunity. 70:6933-6939
IGTP is a member of the 47-kDa family of gamma interferon (IFN-γ)-induced GTPases. We have previously shown that IGTP is critical for host resistance toToxoplasma gondiiinfection. In the present study, we demonstrate thatT. gondii-induced IGTP expre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd1743fc5aed644b6714c60f6db130dd
https://doi.org/10.1128/iai.70.12.6933-6939.2002
https://doi.org/10.1128/iai.70.12.6933-6939.2002
Autor:
Alan Sher, Patricia Caspar, Dragana Jankovic, John J. Letterio, Allen W. Cheever, Marika C. Kullberg, Peter L. Gorelick
Publikováno v:
The Journal of Experimental Medicine
We have previously demonstrated that interleukin (IL)-10-deficient (IL-10 knockout [KO]) but not wild-type (WT) mice develop colitis after infection with Helicobacter hepaticus. Here, we show that infected recombination activating gene (RAG) KO mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a40b2347fb19724a47f3d9df40eaeb60
https://doi.org/10.1084/jem.20020556
https://doi.org/10.1084/jem.20020556
Autor:
Alan Sher, Antonio Gigliotti Rothfuchs, Dragana Jankovic, Patricia Caspar, Allen W. Cheever, Marika C. Kullberg, Peter L. Gorelick, Thomas A. Wynn
Publikováno v:
Infection and Immunity. 69:4232-4241
We have previously shown that specific-pathogen-free interleukin-10 (IL-10)-deficient (IL-10 KO) mice reconstituted withHelicobacter hepaticusdevelop severe colitis associated with a Th1-type cytokine response. In the present study, we formally demon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f7671d0d97c1fd18c57ccfb47856258
https://doi.org/10.1128/iai.69.7.4232-4241.2001
https://doi.org/10.1128/iai.69.7.4232-4241.2001