Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Patricia Casado Castro"'
Autor:
Simon R. Green, Susan H. Davis, Sebastian Damerow, Curtis A. Engelhart, Michael Mathieson, Beatriz Baragaña, David A. Robinson, Jevgenia Tamjar, Alice Dawson, Fabio K. Tamaki, Kirsteen I. Buchanan, John Post, Karen Dowers, Sharon M. Shepherd, Chimed Jansen, Fabio Zuccotto, Ian H. Gilbert, Ola Epemolu, Jennifer Riley, Laste Stojanovski, Maria Osuna-Cabello, Esther Pérez-Herrán, María José Rebollo, Laura Guijarro López, Patricia Casado Castro, Isabel Camino, Heather C. Kim, James M. Bean, Navid Nahiyaan, Kyu Y. Rhee, Qinglan Wang, Vee Y. Tan, Helena I. M. Boshoff, Paul J. Converse, Si-Yang Li, Yong S. Chang, Nader Fotouhi, Anna M. Upton, Eric L. Nuermberger, Dirk Schnappinger, Kevin D. Read, Lourdes Encinas, Robert H. Bates, Paul G. Wyatt, Laura A. T. Cleghorn
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Tuberculosis is a major cause of mortality, and the rise of drug-resistant strains of Mycobacterium tuberculosis requires the urgent development of safe and effective treatments. In this work, the authors develop a compound against lysyl-tRNA synthet
Externí odkaz:
https://doaj.org/article/3aefb9dc25794e5b8cda7dfd998654ed
Autor:
Carine Sao Emani, Clement K. M. Tsui, Adama Bojang, Flavia Sorrentino, Yossef Av-Gay, María José Rebollo-López, Gagandeep Narula, Blanco Modesto J Remuinan, Eva Maria Lopez-Roman, Abraham L Moure, Beatriz Hernández Díaz, Esther Porras de Francisco, Patricia Casado Castro, Laura Guijarro López, Pedro Alfonso Torres-Gomez, Fátima Ortega, David Barros-Aguirre, Lluis Ballell, Isabel Camino
Publikováno v:
Journal of Medicinal Chemistry. 63:4732-4748
Screening of a GSK-proprietary library against intracellular Mycobacterium tuberculosis identified 1, a thioalkylbenzoxazole hit. Biological profiling and mutant analysis revealed that this compound is a prodrug that is bioactivated by the mycobacter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37597b28e01469f812a39e15644a876b
https://doi.org/10.1021/acs.jmedchem.0c00003
https://doi.org/10.1021/acs.jmedchem.0c00003