Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Patricia C. Weber"'
Autor:
Xu Han, Yang Mei, Rama K. Mishra, Honghao Bi, Atul D. Jain, Gary E. Schiltz, Baobing Zhao, Madina Sukhanova, Pan Wang, Arabela A. Grigorescu, Patricia C. Weber, John J. Piwinski, Miguel A. Prado, Joao A. Paulo, Len Stephens, Karen E. Anderson, Charles S. Abrams, Jing Yang, Peng Ji
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 6 (2023)
Myeloproliferative neoplasms (MPNs) are characterized by the activated JAK2/STAT pathway. Pleckstrin-2 (Plek2) is a downstream target of the JAK2/STAT5 pathway and is overexpressed in patients with MPNs. We previously revealed that Plek2 plays critic
Externí odkaz:
https://doaj.org/article/2701d1efe9e540b6893f0cff3edaf376
Autor:
Tadatoshi Sato, Christian D. Castro Andrade, Sung-Hee Yoon, Yingshe Zhao, William J. Greenlee, Patricia C. Weber, Usha Viswanathan, John Kulp, Daniel J. Brooks, Marie B. Demay, Mary L. Bouxsein, Bruce Mitlak, Beate Lanske, Marc N. Wein
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(50)
Osteoporosis is a major public health problem. Currently, there are no orally available therapies that increase bone formation. Intermittent parathyroid hormone (PTH) stimulates bone formation through a signal transduction pathway that involves inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6fb817191c9c4d82d8a4ca4bdafcdb9
https://pubmed.ncbi.nlm.nih.gov/36472957
https://pubmed.ncbi.nlm.nih.gov/36472957
Autor:
Shane Atwell, Christie G. Brouillette, K. Conners, Patricia C. Weber, Jorg Hendle, S.R. Wasserman, William B. Guggino, Diana R. Wetmore, Hal A. Lewis, Tarun Gheyi, R. Romero, Irina I. Protasevich, Feiyu F. Zhang, Frances Lu, John F. Hunt, Logan Rodgers, S. Emtage, Xun Zhao
Publikováno v:
Protein Engineering, Design and Selection. 23:375-384
Upon removal of the regulatory insert (RI), the first nucleotide binding domain (NBD1) of human cystic fibrosis transmembrane conductance regulator (CFTR) can be heterologously expressed and purified in a form that remains stable without solubilizing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dadd76d9da4d00a6e87bfef5fbefe72a
https://doi.org/10.1093/protein/gzq004
https://doi.org/10.1093/protein/gzq004
Autor:
Birendra N. Pramanik, Yan-Hui Liu, Patricia C. Weber, Urooj A. Mirza, Ajay K. Bose, Y.H. Ing, Peter L. Bartner
Publikováno v:
Protein Science. 11:2676-2687
Accelerated proteolytic cleavage of proteins under controlled microwave irradiation has been achieved. Selective peptide fragmentation by endoproteases trypsin or lysine C led to smaller peptides that were analyzed by matrix-assisted laser desorption
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::647c9915c83839cdf73f9c00399c82f2
https://doi.org/10.1110/ps.0213702
https://doi.org/10.1110/ps.0213702
Autor:
Liu Yi-Tsung, Frank Bennett, Viyyoor M. Girijavallabhan, F. George Njoroge, Lata Ramanathan, John Pichardo, Kevin X. Chen, S. Shane Taremi, Andrew Prongay, Brian M. Beyer, Corey Strickland, Rumin Zhang, Vincent Madison, Edwin Jao, Zhuyan Guo, Zhi Hong, Patricia C. Weber, Anil K. Saksena, Stephane L. Bogen, Srikanth Venkatraman, Rong-Sheng Yang, Nanhua Yao, Joseph E. Myers, Bruce A. Malcolm, Taisa Yarosh-Tomaine, Raymond G. Lovey, Richard N. Ingram, Ashok Arasappan, Thierry O. Fischmann, Mary M. Senior, Winifred W. Prosise
Publikováno v:
Journal of Synchrotron Radiation
Crystal structures of protease/inhibitor complexes guided optimization of the buried nonpolar surface area thereby maximizing hydrophobic binding. The resulting potent tripeptide inhibitor is in clinical trials.
The structures of both native and
The structures of both native and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a19c454d4a047e4eb08a7af266267ad8
http://europepmc.org/articles/PMC2394794
http://europepmc.org/articles/PMC2394794
Autor:
Nanhua Yao, Lata Ramanathan, Kevin X. Chen, Thierry O. Fischmann, Andrew Prongay, Corey Strickland, Mary M. Senior, Raymond G. Lovey, Richard N. Ingram, Bruce A. Malcolm, Viyyoor M. Girijavallabhan, Frank Bennett, Patricia C. Weber, Taisa Yarosh-Tomaine, John Pichardo, Anil K. Saksena, F. George Njoroge, Rong-Sheng Yang, Zhuyan Guo, Zhi Hong, Stephane L. Bogen, Srikanth Venkatraman, Ashok Arasappan, S. Shane Taremi, Brian M. Beyer, Rumin Zhang, Vincent Madison, Edwin Jao, Winifred W. Prosise, Yi-Tsung Liu, Joseph E. Myers
Publikováno v:
Journal of Medicinal Chemistry. 50:2310-2318
The structures of both the native holo-HCV NS3/4A protease domain and the protease domain with a serine 139 to alanine (S139A) mutation were solved to high resolution. Subsequently, structures were...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12ac27152dd419adc5be903b98a4f491
https://doi.org/10.1021/jm060173k
https://doi.org/10.1021/jm060173k
Autor:
Bomina Yu, John F. Hunt, Yoshitomo Hamuro, Brian R. Gibney, William Edstrom, Jordi Benach, Patricia C. Weber
Publikováno v:
Nature. 439:879-884
Nucleic acid damage by environmental and endogenous alkylation reagents creates lesions that are both mutagenic and cytotoxic, with the latter effect accounting for their widespread use in clinical cancer chemotherapy1,2. Escherichia coli AlkB3,4,5,6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f22fb753f8c45a687aa14277bd110c4
https://doi.org/10.1038/nature04561
https://doi.org/10.1038/nature04561
Autor:
Prakash Rao Pendyala, Kohei Yokoyama, Louis J. Lombardo, Andrew D. Hamilton, Frederick S. Buckner, David M. Floyd, Pravin Bendale, Kasey Rivas, Said M. Sebti, Carolyn P. Hornéy, David K. Williams, Laxman Nallan, Debopam Chakrabarti, William T. Windsor, Patricia C. Weber, Wesley C. Van Voorhis, Michael H. Gelb, Kevin D. Bauer
Publikováno v:
Journal of Medicinal Chemistry. 48:3704-3713
New therapeutics to combat malaria are desperately needed. Here we show that the enzyme protein farnesyltransferase (PFT) from the malaria parasite Plasmodium falciparum (P. falciparum) is an ideal drug target. PFT inhibitors (PFTIs) are well tolerat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f878aaa62e14afe6057d5dd9b905b83
https://doi.org/10.1021/jm0491039
https://doi.org/10.1021/jm0491039
Autor:
Lalwani Tarik, Patricia C. Weber, Paul Kirschmeier, Mark E. Snow, Ming Liu, Amin A. Nomeir, Linda James, Viyyoor M. Girijavallabhan, William T. Windsor, Robert Patton, Aki Cynthia J, Corey Strickland, Frank Hollinger, Doll Ronald J, Chao Jianping, Taveras Arthur G
Publikováno v:
Journal of Medicinal Chemistry. 45:3854-3864
The 10-bromobenzocycloheptapyridyl farnesyl transferase inhibitor (FTI) Sch-66336 (1) is currently under clinical evaluation for the treatment of human cancers. During structure-activity relationship development leading to 1, 10-bromobenzocycloheptap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::519d505c7e685bc629614c709a3c3cf5
https://doi.org/10.1021/jm010463v
https://doi.org/10.1021/jm010463v