Zobrazeno 1 - 8
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pro vyhledávání: '"Patricia C. Brooks"'
Publikováno v:
Journal of Bacteriology. 188:6034-6038
The mycobacterium-specific gene Rv2719c was found to be expressed primarily from a promoter that was clearly DNA damage inducible independently of RecA. Upstream of the transcriptional start site for this promoter, sequence motifs resembling those ob
Publikováno v:
Microbiology. 148:3609-3615
Four potential binding sites for LexA were identified upstream of the Mycobacterium tuberculosis lexA gene. A mutational analysis of these sites in a lexA-lacZ reporter construct revealed that only one of these SOS boxes was required for DNA-damage-m
Autor:
M. Joseph Colston, Colin Anderson, K. G. Papavinasasundaram, Farahnaz Movahedzadeh, Elaine O. Davis, Patricia C. Brooks, Nicola A. Thomas, Peter J. Jenner
Publikováno v:
Microbiology. 147:3271-3279
In mycobacteria, as in most bacterial species, the expression of RecA is induced by DNA damage. However, the authors show here that the kinetics of recA induction in Mycobacterium smegmatis and in Mycobacterium tuberculosis are quite different: whils
Publikováno v:
Journal of Bacteriology. 183:4459-4467
The repair of DNA damage is likely to be important to pathogens such as Mycobacterium tuberculosis which reside within the very host cells intended to be a defense against infection. Although M. tuberculosis is able to modify the maturation of the no
Publikováno v:
The EMBO Journal. 13:699-703
Protein introns are recently discovered genetic elements whose intervening sequences are removed from a precursor protein by an unusual protein splicing reaction. This involves the excision of a central spacer molecule, the protein intron, and the re
Publikováno v:
Cell. 71:201-210
The M. tuberculosis recA locus comprises an 85 kd open reading frame but produced 38 kd RecA and 47 kd products in E. coli. No RNA processing was detected; rather, an 85 kd precursor protein was spliced, releasing a 47 kd spacer protein, and joining
Publikováno v:
Journal of Bacteriology
Journal of Bacteriology, American Society for Microbiology, 2003, 185, pp.6005-6015
Journal of Bacteriology, American Society for Microbiology, 2003, 185, pp.6005-6015
International audience; The recA gene of Mycobacterium tuberculosis is unusual in that it is expressed from two promoters, one of which, P1, is DNA damage inducible independently of LexA and RecA, while the other, P2, is regulated by LexA in the clas
Autor:
Grainger G. Muir, Patricia C. Brooks
Publikováno v:
BJOG: An International Journal of Obstetrics and Gynaecology. 74:111-114