Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Patricia C Giclas"'
Autor:
Joshua M Thurman, Maria Wong, Brandon Renner, Ashley Frazer-Abel, Patricia C Giclas, Melanie S Joy, Diana Jalal, Milena K Radeva, Jennifer Gassman, Debbie S Gipson, Frederick Kaskel, Aaron Friedman, Howard Trachtman
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0136558 (2015)
Recent pre-clinical studies have shown that complement activation contributes to glomerular and tubular injury in experimental FSGS. Although complement proteins are detected in the glomeruli of some patients with FSGS, it is not known whether this i
Externí odkaz:
https://doaj.org/article/767634e2577e42f5aca544c7c4cf620b
Autor:
Jenna Yee, Lijiang Shen, Patricia C. Giclas, Todd Machemer, Gene Hung, John Matson, Bryan Tayefeh, Scott P. Henry, Rie Kikkawa, Jeffrey A Engelhardt
Publikováno v:
Nucleic Acid Therapeutics. 26:236-249
The effects of repeated complement activation in cynomolgus monkeys after chronic antisense oligonucleotide (ASO) treatment were evaluated by using ISIS 104838, a representative 2'-O-methoxyethyl (2'-MOE) modified ASO. The treatment was up to 9 month
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a794fced9a4cffd578e6a4498d8da01
https://doi.org/10.1089/nat.2015.0584
https://doi.org/10.1089/nat.2015.0584
Autor:
Lijiang Shen, Patricia C. Giclas, Michael K. Pangburn, Alfred Chappell, Paul R. Reynolds, Ashley Frazer-Abel, Scott P. Henry, Husam Younis
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 351:709-717
Differences in sensitivity of monkeys and humans to antisense oligonucleotide (ASO)-induced complement alternative pathway (AP) activation were evaluated in monkeys, humans, and in serum using biochemical assays. Transient AP activation was evident i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff0364d32afaadda8615ec7a57d43b90
https://doi.org/10.1124/jpet.114.219378
https://doi.org/10.1124/jpet.114.219378
Autor:
Patricia C. Giclas
Publikováno v:
Manual of Molecular and Clinical Laboratory Immunology
Complement evolved in parallel with coagulation as part of the primordial explosion of life in the Cambrian era. Remnants of this connection still exist in vertebrate animals as well as invertebrates. A classic example is the horseshoe crab, Limulus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98abf475938de3e2979120c33ec6ce68
https://doi.org/10.1128/9781555818722.ch13
https://doi.org/10.1128/9781555818722.ch13
Autor:
Timothy H.J. Goodship, Lennart Truedsson, Patricia C. Giclas, Danielle Paixão-Cavalcante, B. Paul Morgan, Claire L. Harris, Margarita López-Trascasa, Santiago Rodríguez de Córdoba, Lillemor Skattum
Publikováno v:
Kidney International
C3 nephritic factors are autoantibodies that prolong the half-life or prevent regulation of the alternative pathway C3 convertase, resulting in uncontrolled complement activation. They are strongly associated with renal disease but their role in path
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e90bdf5dbe611dcfc18e03c0cf98d06d
https://doi.org/10.1038/ki.2012.250
https://doi.org/10.1038/ki.2012.250
Autor:
James L. Mueller, Lori Broderick, Hal M. Hoffman, Christopher D. Putnam, Chhavi Gandhi, Karin S. Peterson, Seema S. Aceves, Patricia C. Giclas, Katayoon Shayan, Robert O. Newbury, Bradley M. Peterson, John F. Bastian, Robert Sheets
Publikováno v:
Journal of Clinical Immunology. 33:162-171
Acute Hemorrhagic Leukoencephalitis (AHLE) is a rare demyelinating disorder of acute onset, rapid deterioration and significant morbidity and mortality. Most often described as a post-infectious complication of an upper respiratory illness, its preci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbef5eb32e0dddf63d1cc264795af7f9
https://doi.org/10.1007/s10875-012-9767-z
https://doi.org/10.1007/s10875-012-9767-z
Autor:
Matthew Eggleston, Vijaya Knight, Jaclyn Dennis, Jordan K. Abbott, Erin Archuleta, Patricia C. Giclas
Publikováno v:
Molecular Immunology. 89:145-146
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29fcff4dbf5603a43c81655ac244ce75
https://doi.org/10.1016/j.molimm.2017.06.095
https://doi.org/10.1016/j.molimm.2017.06.095
Autor:
Patricia C. Giclas, Ashley Frazer-Abel
Publikováno v:
Allergy and Asthma Proceedings. 32:17-21
The importance of laboratory testing in the diagnosis of hereditary angioedema (HAE) has increased with the advent of new treatment options in recent years. It has been 50 years since HAE was linked to a decrease of C1INH (the inhibitor of complement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e025175da2bd9242d670705796c9a43
https://doi.org/10.2500/aap.2011.32.3472
https://doi.org/10.2500/aap.2011.32.3472