Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Patricia C, Edwards"'
Autor:
Anastasiia Gusach, Yang Lee, Armin Nikpour Khoshgrudi, Elizaveta Mukhaleva, Ning Ma, Eline J. Koers, Qingchao Chen, Patricia C. Edwards, Fanglu Huang, Jonathan Kim, Filippo Mancia, Dmitry B. Veprintsev, Nagarajan Vaidehi, Simone N. Weyand, Christopher G. Tate
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract There are two main families of G protein-coupled receptors that detect odours in humans, the odorant receptors (ORs) and the trace amine-associated receptors (TAARs). Their amino acid sequences are distinct, with the TAARs being most similar
Externí odkaz:
https://doaj.org/article/652fff5f256d4ddc952071804619e0c2
Autor:
Nathanial C Stevens, Veneese J Brown, Morgan C Domanico, Patricia C Edwards, Laura S Van Winkle, Oliver Fiehn
Publikováno v:
Toxicological Sciences. 191:79-89
Asthma is a common chronic respiratory disease exacerbated by multiple environmental factors. Acute ozone exposure has previously been implicated in airway inflammation, airway hyperreactivity, and other characteristics of asthma, which may be attrib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d41d76dd238dc259d2cd0a0e7c60c3a5
https://doi.org/10.1093/toxsci/kfac117
https://doi.org/10.1093/toxsci/kfac117
Autor:
Rony Nehmé, Byron Carpenter, Ankita Singhal, Annette Strege, Patricia C Edwards, Courtney F White, Haijuan Du, Reinhard Grisshammer, Christopher G Tate
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0175642 (2017)
Mini-G proteins are the engineered GTPase domains of Gα subunits. They couple to GPCRs and recapitulate the increase in agonist affinity observed upon coupling of a native heterotrimeric G protein. Given the small size and stability of mini-G protei
Externí odkaz:
https://doaj.org/article/a5fac57f40484242b84cb93eef39e9ee
Autor:
Morgan Domanico, Atsuhiko Fukuto, Lisa M. Tran, Jessica-Miranda Bustamante, Patricia C. Edwards, Kent E. Pinkerton, Sara M. Thomasy, Laura S. Van Winkle
Two-dimensional (2D) engineered nanomaterials are widely used in consumer and industrial goods due to their unique chemical and physical characteristics. Engineered nanomaterials are incredibly small and capable of being aerosolized during manufactur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0be68fe8895dd82ba8e84f59a38220f5
https://escholarship.org/uc/item/5kf2b43c
https://escholarship.org/uc/item/5kf2b43c
Autor:
Natalie Di Bartolo, Emma L R Compton, Tony Warne, Patricia C Edwards, Christopher G Tate, Gebhard F X Schertler, Paula J Booth
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0151582 (2016)
The factors defining the correct folding and stability of integral membrane proteins are poorly understood. Folding of only a few select membrane proteins has been scrutinised, leaving considerable deficiencies in knowledge for large protein families
Externí odkaz:
https://doaj.org/article/0ef8c841adb849ae9f0ed741cb3e29c8
Autor:
Oliver Fiehn, Nathanial C. Stevens, Laura S. Van Winkle, Xinxin Ding, Lisa M. Tran, Patricia C. Edwards
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology, vol 184, iss 2
Toxicol Sci
Toxicol Sci
Naphthalene is a ubiquitous environmental contaminant produced by combustion of fossil fuels and is a primary constituent of both mainstream and side stream tobacco smoke. Naphthalene elicits region-specific toxicity in airway club cells through cyto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9612ae4e68d4da297608a647dbc7e51
https://escholarship.org/uc/item/7n94c2cv
https://escholarship.org/uc/item/7n94c2cv
Autor:
Patricia C. Edwards, Timothy R. Dafforn, Christopher G. Tate, Bert Klumperman, Richard T Logan, David R. Poyner, Pooja Sridhar, Mark Wheatley, Philip J. Reeves, Rachael L. Grime, Stephanie A Nestorow
Publikováno v:
Nanoscale
Membrane proteins are of fundamental importance to cellular processes and nano-encapsulation strategies that preserve their native lipid bilayer environment are particularly attractive for studying and exploiting these proteins. Poly(styrene-co-malei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca890f5d9a386b570db170c5e4c20636
https://pubmed.ncbi.nlm.nih.gov/34477756
https://pubmed.ncbi.nlm.nih.gov/34477756
Autor:
Cyrill Brunner, Agnieszka M Olechwier, Na Wu, Christopher G. Tate, Pikyee Ma, Patricia C. Edwards, Xavier Deupi, Renato Zenobi, Ching-Ju Tsai, Gebhard F. X. Schertler, Gisbert Schneider
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance G protein–coupled receptors (GPCRs) are important pharmaceutical targets for the treatment of a broad spectrum of diseases. Upon ligand binding, GPCRs initiate intracellular signaling pathways by interacting with partner proteins. Assa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dfdcacae417e2dbaf83e0a6d734ad3c
http://europepmc.org/articles/PMC8346855
http://europepmc.org/articles/PMC8346855
Autor:
Y. Lee, Richard Henderson, Shaoxia Chen, Katerina Naydenova, Christopher J. Russo, E. Leahy, M. J. Peet, Greg McMullan, S. Scotcher, Patricia C. Edwards
Publikováno v:
IUCrJ
IUCrJ, Vol 6, Iss 6, Pp 1086-1098 (2019)
IUCrJ, Vol 6, Iss 6, Pp 1086-1098 (2019)
Several structures were determined by single-particle cryoEM at 100 keV and the implications for future electron cryomicroscopes are considered.
100 kV is investigated as the operating voltage for single-particle electron cryomicroscopy (cryoEM)
100 kV is investigated as the operating voltage for single-particle electron cryomicroscopy (cryoEM)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9734ebe04c5b18b180d42b8283aa214
http://europepmc.org/articles/PMC6830209
http://europepmc.org/articles/PMC6830209
Publikováno v:
Science. 364:775-778
A GPCR seen in the active state G protein–coupled receptors (GPCRs) are exceptionally good targets for drug development. Warne et al. describe four crystal structures of complexes of a GPCR—the β1-adrenergic receptor—in its active state. They
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a132f3742142ee0ba7e4749db024ca86
https://doi.org/10.1126/science.aau5595
https://doi.org/10.1126/science.aau5595