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pro vyhledávání: '"Patricia Bremner"'
Autor:
Philip R. Tempest, Elena Barbanti, Marta Ghislieri, Frank J. Carr, Patricia Bremner, Fabrizio Marcucci, Bruno Rifaldi
Publikováno v:
Hybridoma. 13:183-190
We have constructed several humanized versions of a monoclonal antibody (MAb78) against human tumor necrosis factor-alpha (huTNF-alpha) retaining the complementarity-determining regions (CDR) of the original mouse MAb with or without a variable numbe
Reshaping a human monoclonal antibody to inhibit human respiratory syncytial virus infection in vivo
Autor:
Martin Lambert, Philip R. Tempest, William J. Harris, Geraldine Taylor, J. Furze, Frank J. Carr, Patricia Bremner
Publikováno v:
Bio/technology (Nature Publishing Company). 9(3)
We transferred the complementarity determining regions from a murine monoclonal antibody that neutralizes infection by respiratory syncytial virus (RSV) to a human IgG1 monoclonal antibody. The resulting reshaped human antibody lost affinity for RSV,