Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Patricia B. Eisenhauer"'
Autor:
Kelly J. Conn, Isabel Carreras, Ana M. George, Ann C. McKee, Wenwu Gao, Richard E. Fine, John M. Wells, John A. Lynch, Patricia B. Eisenhauer, M. David Ullman
Publikováno v:
Journal of Neuroscience Research. 83:1262-1270
Insulin degrading enzyme (IDE) is expressed in the brain and may play an important role there in the degradation of the amyloid beta peptide (Abeta). Our results show that cultured human cerebrovascular endothelial cells (HCECs), a primary component
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae987982e10f92b70f6b55c046b966fe
https://doi.org/10.1002/jnr.20809
https://doi.org/10.1002/jnr.20809
Autor:
Rosemary Garrett-Young, Kelly J. Conn, John M. Wells, Richard E. Fine, Isabel Carreras, Patricia B. Eisenhauer, M. David Ullman
Publikováno v:
Journal of Neuroscience Research. 79:495-502
Clusterin (apolipoprotein J) is a highly conserved, multifunctional, vertebrate glycoprotein. Several isoforms of clusterin have been described including the predominant secreted isoform (sCLU) and several nuclear isoforms (nCLU) associated with cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc0fdca19807ef758e3df5c2ba1a1fb9
https://doi.org/10.1002/jnr.20374
https://doi.org/10.1002/jnr.20374
Autor:
Hamant S. Thatte, Patricia B. Eisenhauer, M. David Ullman, Kelly J. Conn, John A. Lynch, John M. Wells, Ann C. McKee, Richard E. Fine, Wenwu Gao
Publikováno v:
Neuroscience Letters. 371:6-11
Insulin degrading enzyme (IDE) is found in the cytosol, peroxisomes and plasma membrane of many cells. Although it preferentially cleaves insulin it can also cleave many other small proteins with diverse sequences including the monomeric form of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8768169bf09e1eddeccb8474e76a56d
https://doi.org/10.1016/j.neulet.2004.07.034
https://doi.org/10.1016/j.neulet.2004.07.034
Autor:
John M. Wells, Kelly J. Conn, Richard E. Fine, Patricia B Eisenhauer, David S. Newburg, Mary S Jacewicz, Omanand Koul
Publikováno v:
Microbial Pathogenesis. 36:189-196
Infection with Shiga toxin (Stx)-producing Escherichia coli can lead to development of hemolytic uremic syndrome (HUS). Patients with severe HUS often exhibit central nervous system (CNS) pathology, which is thought to involve damage to brain endothe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e803c66482347dc9c3cf77eac463a6fd
https://doi.org/10.1016/j.micpath.2003.11.004
https://doi.org/10.1016/j.micpath.2003.11.004
Autor:
Patricia B. Eisenhauer, M. David Ullman, Kelly J. Conn, John M. Wells, Richard E. Fine, Michelle J. Larned
Publikováno v:
Neurochemical Research. 28:1873-1881
cDNA microarray analysis of 1-methyl-4-phenyl-pyridinium (MPP+) toxicity (1 mM, 72 h) in undifferentiated SH-SY5Y cells identified 48 genes that displayed a signal intensity greater than the mean of all differentially expressed genes and a two-fold o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bdb53a644cfeaec1eb5f3a51d9689b05
https://doi.org/10.1023/a:1026179926780
https://doi.org/10.1023/a:1026179926780
Autor:
Patricia B. Eisenhauer, Richard E. Fine, M. David Ullman, Catherine McKeon-O'Malley, Wenwu Gao, John M. Wells, Kelly J. Conn
Publikováno v:
Journal of Neuroscience Research. 68:755-760
Growth arrest DNA damage-inducible 153 (GADD153) expression was increased in 1-methyl-4-phenyl-pyridinium (MPP(+))-treated human SH-SY5Y neuroblastoma cells as determined by gene microarray analysis. GADD153 expression increased after 24 hr of MPP(+)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e65fa56e59af7919669f909af69100f
https://doi.org/10.1002/jnr.10252
https://doi.org/10.1002/jnr.10252
Autor:
Barbara A. Gilchrest, Richard E. Fine, Sen Zhai, Mina Yaar, Bennett L. Arble, Patricia B. Eisenhauer, Kenneth B. Stewart
Publikováno v:
Journal of Biological Chemistry. 277:7720-7725
p75(NTR), a nerve growth factor co-receptor that has been implicated in apoptosis of neurons, is structurally related to Fas and the receptors for tumor necrosis factor-alpha that display ligand independent assembly into trimers. Using embryonic day
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4150de4c4e291e4c39373cc36796d02d
https://doi.org/10.1074/jbc.m110929200
https://doi.org/10.1074/jbc.m110929200
Publikováno v:
Journal of Neuroscience Research. 60:804-810
The amyloid beta peptide (A beta) is the major component of the neuritic and cerebrovascular amyloid plaques that are one of the characteristic features of Alzheimer's disease (AD). This peptide has been shown to be toxic to several relevant cell typ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a729b51f34c13a9dde00e992c4eda6a5
https://doi.org/10.1002/1097-4547(20000615)60:6<804::aid-jnr13>3.0.co
https://doi.org/10.1002/1097-4547(20000615)60:6<804::aid-jnr13>3.0.co
Autor:
John Henry Wells, Heather Tibbles, Andrea M. Billingslea, Richard E. Fine, Theresa A. Davies, Derek C.L. Marshall, Patricia B. Eisenhauer, David H. Cribbs, Carmela R. Abraham, Kim Otto, Heidi J. Long, Elizabeth R. Simons
Publikováno v:
Amyloid. 5:153-162
Proteolytic cleavage of the amyloid precursor protein (A beta PP) results in the generation of the amyloidogenic fragment known as amyloid beta peptide (A beta). Deposition of A beta in the brain parenchyma and cerebrovasculature is a feature of Alzh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0c613cf70a31f329a0a7a0d4c81526b
https://doi.org/10.3109/13506129809003841
https://doi.org/10.3109/13506129809003841
Autor:
Barbara A. Gilchrest, Richard E. Fine, Paul F. Pilch, Mina Yaar, Sineaid M. Doyle, S Zhai, Patricia B. Eisenhauer
Publikováno v:
Journal of Clinical Investigation. 100:2333-2340
Alzheimer's disease is a neurodegenerative disorder characterized by the extracellular deposition in the brain of aggregated beta-amyloid peptide, presumed to play a pathogenic role, and by preferential loss of neurons that express the 75-kD neurotro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0482a8d0b6670be28fb978a3ee0d96b
https://doi.org/10.1172/jci119772
https://doi.org/10.1172/jci119772