Zobrazeno 1 - 10
of 155
pro vyhledávání: '"Patricia Aspichueta"'
Autor:
Laura Schmitt, Karina S. Krings, Andre Wolsing, Xabier Buque, Marcel Zimmermann, Hector Flores-Romero, Thomas Lenz, Ilka Lechtenberg, Christoph Peter, Björn Stork, Nicole Teusch, Peter Proksch, Kai Stühler, Ana J. García-Sáez, Andreas S. Reichert, Patricia Aspichueta, Sanil Bhatia, Sebastian Wesselborg
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-22 (2024)
Abstract Targeting mitochondrial metabolism represents a promising approach for cancer treatment. Here, we investigated the mitotoxic potential of the polybrominated diphenyl ether bromoxib, a natural compound isolated from the marine sponge Dysidea
Externí odkaz:
https://doaj.org/article/9172168f3c784c2f8b3a4f970bd907a9
Autor:
Patricia Rada, Elena Carceller-López, Ana B. Hitos, Beatriz Gómez-Santos, Constanza Fernández-Hernández, Esther Rey, Julia Pose-Utrilla, Carmelo García-Monzón, Águeda González-Rodríguez, Guadalupe Sabio, Antonia García, Patricia Aspichueta, Teresa Iglesias, Ángela M. Valverde
Publikováno v:
Molecular Metabolism, Vol 90, Iss , Pp 102045- (2024)
Objectives: Protein kinase D (PKD) family is emerging as relevant regulator of metabolic homeostasis. However, the precise role of PKD2 in modulating hepatic insulin signaling has not been fully elucidated and it is the aim of this study. Methods: PK
Externí odkaz:
https://doaj.org/article/abf0bce88beb4a23b4cb4540fea29630
Autor:
Diego Sáenz de Urturi, Xabier Buqué, Begoña Porteiro, Cintia Folgueira, Alfonso Mora, Teresa C. Delgado, Endika Prieto-Fernández, Paula Olaizola, Beatriz Gómez-Santos, Maider Apodaka-Biguri, Francisco González-Romero, Ane Nieva-Zuluaga, Mikel Ruiz de Gauna, Naroa Goikoetxea-Usandizaga, Juan Luis García-Rodríguez, Virginia Gutierrez de Juan, Igor Aurrekoetxea, Valle Montalvo-Romeral, Eva M. Novoa, Idoia Martín-Guerrero, Marta Varela-Rey, Sanjay Bhanot, Richard Lee, Jesus M. Banales, Wing-Kin Syn, Guadalupe Sabio, María L. Martínez-Chantar, Rubén Nogueiras, Patricia Aspichueta
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
High methionine and S-adenosylmethionine serum levels are related with obesity. Here the authors show that knockdown of methionine adenosyltransferase by using antisense oligonucleotides provides beneficial effects in obesity and comorbidities.
Externí odkaz:
https://doaj.org/article/679efae112224ba6a2829203d49df6dc
Autor:
Abudukadier Abulizi, Daniel F. Vatner, Zhang Ye, Yongliang Wang, Joao-Paulo Camporez, Dongyan Zhang, Mario Kahn, Kun Lyu, Alaa Sirwi, Gary W. Cline, M. Mahmood Hussain, Patricia Aspichueta, Varman T. Samuel, Gerald I. Shulman
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 12, Pp 1565-1576 (2020)
Microsomal triglyceride transfer protein (MTTP) deficiency results in a syndrome of hypolipidemia and accelerated NAFLD. Animal models of decreased hepatic MTTP activity have revealed an unexplained dissociation between hepatic steatosis and hepatic
Externí odkaz:
https://doaj.org/article/4a127f1e875f4bd1bff152707a536e82
Autor:
Lucía Barbier-Torres, Karen A. Fortner, Paula Iruzubieta, Teresa C. Delgado, Emily Giddings, Youdinghuan Chen, Devin Champagne, David Fernández-Ramos, Daniela Mestre, Beatriz Gomez-Santos, Marta Varela-Rey, Virginia Gutiérrez de Juan, Pablo Fernández-Tussy, Imanol Zubiete-Franco, Carmelo García-Monzón, Águeda González-Rodríguez, Dhaval Oza, Felipe Valença-Pereira, Qian Fang, Javier Crespo, Patricia Aspichueta, Frederic Tremblay, Brock C. Christensen, Juan Anguita, María Luz Martínez-Chantar, Mercedes Rincón
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Non-alcoholic fatty liver (NAFLD) disease causes degeneration of the liver, affects about 25% of people globally, and has no approved treatment. Here, the authors show that the therapeutic siRNA-driven silencing of MCJ in the liver is an effective an
Externí odkaz:
https://doaj.org/article/f4585c15ec8641c2ad4a105f86c1a9ca
Autor:
Marina Serrano-Maciá, Jorge Simón, Maria J. González-Rellan, Mikel Azkargorta, Naroa Goikoetxea-Usandizaga, Fernando Lopitz-Otsoa, Diego Saenz De Urturi, Rubén Rodríguez-Agudo, Sofia Lachiondo-Ortega, Maria Mercado-Gomez, Virginia Gutiérrez de Juan, Maider Bizkarguenaga, David Fernández-Ramos, Xabier Buque, Guido A. Baselli, Luca V.C. Valenti, Paula Iruzubieta, Javier Crespo, Erica Villa, Jesus M. Banales, Matias A. Avila, Jose J.G. Marin, Patricia Aspichueta, James Sutherland, Rosa Barrio, Ugo Mayor, Félix Elortza, Dimitris P. Xirodimas, Rubén Nogueiras, Teresa C. Delgado, María Luz Martínez-Chantar
Publikováno v:
Molecular Metabolism, Vol 53, Iss , Pp 101275- (2021)
Objective: Neddylation is a druggable and reversible ubiquitin-like post-translational modification upregulated in many diseases, including liver fibrosis, hepatocellular carcinoma, and more recently, non-alcoholic fatty liver disease (NAFLD). Herein
Externí odkaz:
https://doaj.org/article/358512f74108488aa4daf723e0bda944
Autor:
Ayelén M Santamans, Valle Montalvo-Romeral, Alfonso Mora, Juan Antonio Lopez, Francisco González-Romero, Daniel Jimenez-Blasco, Elena Rodríguez, Aránzazu Pintor-Chocano, Cristina Casanueva-Benítez, Rebeca Acín-Pérez, Luis Leiva-Vega, Jordi Duran, Joan J Guinovart, Jesús Jiménez-Borreguero, José Antonio Enríquez, María Villlalba-Orero, Juan P Bolaños, Patricia Aspichueta, Jesús Vázquez, Bárbara González-Terán, Guadalupe Sabio
Publikováno v:
PLoS Biology, Vol 19, Iss 11, p e3001447 (2021)
During the first weeks of postnatal heart development, cardiomyocytes undergo a major adaptive metabolic shift from glycolytic energy production to fatty acid oxidation. This metabolic change is contemporaneous to the up-regulation and activation of
Externí odkaz:
https://doaj.org/article/c36e9e81543246be91c8817f25d367e5
Autor:
Daniel Cabrera, Isabel Rao, Fabiola Raasch, Nancy Solis, Margarita Pizarro, Mariela Freire, Diego Sáenz De Urturi, Carolina A. Ramírez, Nicolás Triantafilo, Jonathan León, Arnoldo Riquelme, Francisco Barrera, Rene Baudrand, Patricia Aspichueta, Marco Arrese, Juan P. Arab
Publikováno v:
Annals of Hepatology, Vol 24, Iss , Pp 100357- (2021)
Introduction and Objectives: Nonalcoholic-fatty-liver disease (NAFLD) is considered the hepatic manifestation of metabolic syndrome (MetS). Mineralocorticoid receptor (MR) activation is associated with increased risk of MetS but few studies have asse
Externí odkaz:
https://doaj.org/article/e20d0545c4c64266bc02630a460ea084
Autor:
Marta Martín-Fernández, Víctor Arroyo, Carmen Carnicero, Rebeca Sigüenza, Reyes Busta, Natalia Mora, Beatriz Antolín, Eduardo Tamayo, Patricia Aspichueta, Irene Carnicero-Frutos, Hugo Gonzalo-Benito, Rocío Aller
Publikováno v:
Antioxidants, Vol 11, Iss 11, p 2217 (2022)
Non-alcoholic fatty liver disease (NAFLD) is characterised by an excess of hepatic fat that can progress to steatohepatitis, fibrosis, cirrhosis and hepatocarcinoma. The imbalance between lipid uptake/lipogenesis and lipid oxidation/secretion in the
Externí odkaz:
https://doaj.org/article/453aa95386484a0ea4777213fa943c83
Autor:
Pablo Fernández-Tussy, David Fernández-Ramos, Fernando Lopitz-Otsoa, Jorge Simón, Lucía Barbier-Torres, Beatriz Gomez-Santos, Maitane Nuñez-Garcia, Mikel Azkargorta, Virginia Gutiérrez-de Juan, Marina Serrano-Macia, Rubén Rodríguez-Agudo, Paula Iruzubieta, Juan Anguita, Rui E. Castro, Devin Champagne, Mercedes Rincón, Felix Elortza, Anita Arslanow, Marcin Krawczyk, Frank Lammert, Mélanie Kirchmeyer, Iris Behrmann, Javier Crespo, Shelly C. Lu, José M. Mato, Marta Varela-Rey, Patricia Aspichueta, Teresa C. Delgado, María L. Martínez-Chantar
Publikováno v:
Molecular Metabolism, Vol 29, Iss , Pp 40-54 (2019)
Objective: Non-alcoholic fatty liver disease (NAFLD) is a complex pathology in which several dysfunctions, including alterations in metabolic pathways, mitochondrial functionality and unbalanced lipid import/export, lead to lipid accumulation and pro
Externí odkaz:
https://doaj.org/article/a17e13bf601849f78b91e8ef169b6cb2