Zobrazeno 1 - 10
of 263
pro vyhledávání: '"Patricia Ashton Prolla"'
Autor:
Grazielle Motta Rodrigues, Maria Clara De Freitas Pinho, Taís da Silveira Fischer, Fabrício Campos, Fernanda de Paris, Fernanda Sales Luiz Vianna, Pâmela Portela da Silva, Patricia Ashton Prolla, Clévia Rosset
Publikováno v:
Brazilian Journal of Infectious Diseases, Vol 27, Iss , Pp 102918- (2023)
Introdução: A memória imunológica para o SARS-CoV-2 fornece proteção a longo prazo, podendo ser adquirida por infecção natural ou por vacinação. As células T de memória oferecem suporte para produção de anticorpos (CD4) ou lise celular
Externí odkaz:
https://doaj.org/article/42d61e5640334f5383548900ded36b6b
Autor:
Renata B. V. Abreu, Ariane S. Pereira, Marcela N. Rosa, Patricia Ashton-Prolla, Viviane A. O. Silva, Matias E. Melendez, Edenir I. Palmero
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Germline TP53 pathogenic variants can lead to a cancer susceptibility syndrome known as Li–Fraumeni (LFS). Variants affecting its activity can drive tumorigenesis altering p53 pathways and their identification is crucial for assessing indi
Externí odkaz:
https://doaj.org/article/e45da8d2b79c463587803a601981cdf7
Autor:
YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Carmen Florencia Suarez, Nicolas S Gonzalez-Foutel, Ahmad Malik, Sebastien Martinez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N Al-Zahrani, Lisa Hoeg, Zhen Yuan Lin, Ricky Tsai, Geraldine Mbamalu, Varda Rotter, Patricia Ashton-Prolla, Jason Moffat, Lucia Beatriz Chemes, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek
Publikováno v:
Molecular Systems Biology, Vol 20, Iss 6, Pp 719-740 (2024)
Abstract Tumor suppressor p53 (TP53) is frequently mutated in cancer, often resulting not only in loss of its tumor-suppressive function but also acquisition of dominant-negative and even oncogenic gain-of-function traits. While wild-type p53 levels
Externí odkaz:
https://doaj.org/article/4644b709c6d143dfb92c748768749b96
Autor:
Natalia Campacci, Rebeca Silveira Grasel, Henrique de Campos Reis Galvão, Lucas França Garcia, Paula Carvalho Ribeiro, Kercy Fram de Jesus de Sena Pereira, José Roberto Goldim, Patricia Ashton-Prolla, Edenir Inêz Palmero
Publikováno v:
Frontiers in Psychology, Vol 15 (2024)
IntroductionCancer Genetic Counseling (CGC) and genetic testing (GT) assume a paramount role for hereditary cancer predisposition syndrome families. We assessed the effects of CGC and GT on women affected by cancer who are at risk for hereditary brea
Externí odkaz:
https://doaj.org/article/ac6b1c0b14a14b17b4e1c102022c97c2
Autor:
Arthur Bandeira de Mello Garcia, Guilherme Danielski Viola, Bruno da Silveira Corrêa, Taís da Silveira Fischer, Maria Clara de Freitas Pinho, Grazielle Motta Rodrigues, Patricia Ashton-Prolla, Clévia Rosset
Publikováno v:
Genetics and Molecular Biology, Vol 46, Iss 3 suppl 1 (2024)
Abstract Tuberous Sclerosis Complex (TSC) is caused by loss of function germline variants in the TSC1 or TSC2 tumor suppressor genes. Genetic testing for the detection of pathogenic variants in either TSC1 or TSC2 was implemented as a diagnostic crit
Externí odkaz:
https://doaj.org/article/f61dd32b65814e0d97cdb2432e140347
Autor:
Igor Araujo Vieira, Guilherme Danielski Viola, Eduarda Heidrich Pezzi, Thayne Woycinck Kowalski, Bruna Vieira Fernandes, Tiago Finger Andreis, Natascha Bom, Giulianna Sonnenstrahl, Yasminne Marinho de Araújo Rocha, Bruno da Silveira Corrêa, Luiza Mezzomo Donatti, Gabriela dos Santos Sant’Anna, Helena von Eye Corleta, Ilma Simoni Brum, Clévia Rosset, Fernanda Sales Luiz Vianna, Gabriel S. Macedo, Edenir Inez Palmero, Patricia Ashton-Prolla
Publikováno v:
Genetics and Molecular Biology, Vol 46, Iss 3 suppl 1 (2024)
Abstract The TP53 3’UTR variant rs78378222 A>C has been detected in different tumor types as a somatic alteration that reduces p53 expression through modification of polyadenylation and miRNA regulation. Its prevalence is not yet known in all tumor
Externí odkaz:
https://doaj.org/article/1842083036564d94b5d4456d0ea54ce3
Autor:
Juliana Giacomazzi, Patricia Klarmann Ziegelmann, Samanta da Costa, Camila Matzenbacher Bittar, Fernando Mariano Obst, Clévia Rosset, Gabriel S. Macedo, Hugo Bock, Thais Canal, Mari Ines Paese, Jean Lucas Benvenuti, Maria Carolina Buj, Patricia Ashton-Prolla, José Roberto Goldim, Roberta Pozza
Publikováno v:
JCO Global Oncology, Vol , Iss 9 (2023)
PURPOSETo evaluate cancer risk factors among cancer cases and controls from Southern Brazil, to analyze a multigene hereditary panel testing (MGPT, 26 genes) for breast cancer (BC) and colorectal cancer (CCR) cases diagnosed age younger than 50 years
Externí odkaz:
https://doaj.org/article/6ecf9af14bc44aa09e5bcac27e848684
Autor:
Josef S. Herzog, Yanin Chavarri-Guerra, Danielle Castillo, Julio Abugattas, Cynthia Villarreal-Garza, Sharon Sand, Jessica Clague-Dehart, Rosa M. Alvarez-Gómez, Talia Wegman-Ostrosky, Alejandro Mohar, Pamela Mora, Azucena Del Toro-Valero, Adrian Daneri-Navarro, Yenni Rodriguez, Marcia Cruz-Correa, Patricia Ashton-Prolla, Bárbara Alemar, Rosa Mejia, Lenny Gallardo, Robin Shaw, Kai Yang, Aleck Cervantes, Kevin Tsang, Bita Nehoray, Hugo Barrera Saldana, Susan Neuhausen, Jeffrey N. Weitzel
Publikováno v:
npj Breast Cancer, Vol 7, Iss 1, Pp 1-8 (2021)
Abstract The prevalence and contribution of BRCA1/2 (BRCA) pathogenic variants (PVs) to the cancer burden in Latin America are not well understood. This study aims to address this disparity. BRCA analyses were performed on prospectively enrolled Lati
Externí odkaz:
https://doaj.org/article/cf08a7f700d74cf8b958e3c34a9237a2
Autor:
Maria Isabel Achatz, Maira Caleffi, Rodrigo Guindalini, Renato Moretti Marques, Angelica Nogueira-Rodrigues, Patricia Ashton-Prolla
Publikováno v:
JCO Global Oncology, Vol , Iss 6, Pp 439-452 (2020)
PURPOSE The objective of this review was to address the barriers limiting access to genetic cancer risk assessment and genetic testing for individuals with suspected hereditary breast and ovarian cancer (HBOC) through a review of the diagnosis and ma
Externí odkaz:
https://doaj.org/article/a9a11f3228a54589a1af60abb0fbbeb1
Autor:
Larissa B. Reis, Renato M. Bakos, Fernanda S. L. Vianna, Gabriel S. Macedo, Vanessa C. Jacovas, André M. Ribeiro-dos-Santos, Sidney Santos, Lúcio Bakos, Patricia Ashton-Prolla
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-11 (2020)
Abstract Background Melanoma is the most aggressive type of skin cancer and is associated with environmental and genetic risk factors. It originates in melanocytes, the pigment-producing cells. Single nucleotide polymorphisms (SNPs) in pigmentation g
Externí odkaz:
https://doaj.org/article/3126b9b528a5470591334d4b6ca6c196