Výsledky vyhledávání - "Patricia Armatis"

Inhibition of human androgen-independent PC-3 and DU-145 prostate cancers by antagonists of bombesin and growth hormone releasing hormone is linked to PKC, MAPK and c-jun intracellular signalling

Autor: Anton Stangelberger, Patricia Armatis, Brian D. Hammann, Ren Zhi Cai, Andrew V. Schally, Benjamin Baker, Celia A. Kanashiro, Jozsef L. Varga, Marta Zarandi

Publikováno v: European Journal of Cancer. 41:2735-2744

Bombesin/gastrin-releasing peptide (BN/GRP) antagonists RC-3940-II and RC-3940-Et, and growth hormone-releasing hormone (GHRH) antagonists MZ-J-7-118 and RC-J-29-18 inhibit the growth of human androgen-independent PC-3 and DU-145 prostate cancers in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15d039e3b293c53b526d515325664637
https://doi.org/10.1016/j.ejca.2005.08.022

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Inhibition of Growth of Experimental Human Endometrial Cancer by an Antagonist of Growth Hormone-Releasing Hormone

Autor: Kate Groot, Gabor Halmos, Jozsef L. Varga, Alexandre Havt, Gabor L. Toller, Marta Zarandi, Jörg B. Engel, Gunhild Keller, Andrew V. Schally, Patricia Armatis

Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 90:3614-3621

Antagonists of GHRH are being developed for the treatment of various cancers. In this study we investigated in vivo and in vitro the effects of the GHRH antagonist MZ-J-7-118 and its mechanism of action in HEC-1A human endometrial cancer. Treatment o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb62791ba12848e03cd7e234453465cd
https://doi.org/10.1210/jc.2004-2179

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Inhibitory effects of antagonistic analogs of GHRH on GH3 pituitary cells overexpressing the human GHRH receptor

Autor: Andrew V. Schally, M. Kovacs, Jozsef L. Varga, Kate Groot, Eun Jig Lee, Rebeca Busto, Patricia Armatis

Publikováno v: Journal of Endocrinology. 175:425-434

GH3 rat pituitary tumor cells produce GH and prolactin (PRL), but lack the GHRH receptor (GHRH-R). We expressed human GHRH-R (hGHRH-R) in GH3 cells using recombinant adenoviral vectors and studied the effects of GHRH antagonists. The mRNA expression

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fae1b4349853bf6780d15e3b4c19632d
https://doi.org/10.1677/joe.0.1750425

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Expression of mRNA for growth hormone-releasing hormone and splice variants of GHRH receptors in human malignant bone tumors

Autor: Artur Plonowski, Jozsef L. Varga, Kate Groot, R Busto, R Braczkowski, Magdalena Krupa, Patricia Armatis, Andrew V. Schally

Publikováno v: Regulatory Peptides. 108:47-53

Splice variants (SV) of receptors for growth hormone-releasing hormone (GHRH) have been found in several human cancer cell lines. GHRH antagonists inhibit growth of various human cancers, including osteosarcomas and Ewing's sarcoma, xenografted into

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20ee056be2bbd40180b73c42e00be389
https://doi.org/10.1016/s0167-0115(02)00109-x

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Antagonists of GHRH Decrease Production of GH and IGF-I in MXT Mouse Mammary Cancers and Inhibit Tumor Growth

Autor: Kate Groot, Jozsef L. Varga, Karoly Szepeshazi, Patricia Armatis, Gabor Halmos, Andrew V. Schally, Anita Feil, Francine Hebert

Publikováno v: Endocrinology. 142:4371-4378

The involvement of IGF-I in mammary carcinogenesis is well established, but the role of GH, as an autocrine growth factor for breast cancers is poorly understood. The goal of our study was to investigate whether antagonists of GHRH can interfere with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2c0a239cee658eeeceb9e905445ca43
https://doi.org/10.1210/endo.142.10.8426

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Inhibition of growth and metastases of MDA-MB-435 human estrogen-independent breast cancers by an antagonist of growth hormone-releasing hormone

Autor: Gabor Halmos, Rebeca Busto, Kate Groot, Patricia Armatis, Ioulia Chatzistamou, Jozsef L. Varga, Andrew V. Schally

Publikováno v: Anti-Cancer Drugs. 12:761-768

Antagonists of growth hormone-releasing hormone (GH-RH) inhibit the growth of various cancers by mechanism(s) that include the suppression of the insulin-like growth factors (IGF)-I and/or -II. In this study, nude mice bearing orthotopic implants of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::270286839d9a8cedbcb0a3478aa5bc7d
https://doi.org/10.1097/00001813-200110000-00008

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Antagonists of Growth Hormone-Releasing Hormone and Somatostatin Analog RC-160 Inhibit the Growth of the OV-1063 Human Epithelial Ovarian Cancer Cell Line Xenografted into Nude Mice1

Autor: Kate Groot, Ioulia Chatzistamou, Jozsef L. Varga, Andrew V. Schally, Gabor Halmos, Rebeca Busto, Patricia Armatis

Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 86:2144-2152

The effects of antagonists of GHRH and the somatostatin analog RC-160 on the growth of OV-1063 human epithelial ovarian cancer cells xenografted into nude mice were investigated. Treatment with 20μ g/day of the GHRH antagonist JV-1-36 or MZ-5-156 an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bf913bea6487335d31e967223e3f2edb
https://doi.org/10.1210/jcem.86.5.7487

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Direct action of growth hormone-releasing hormone agonist JI-38 on normal human fibroblasts: Evidence from studies on cell proliferation and c-myc proto-oncogene expression

Autor: Hippokratis Kiaris, Patricia Armatis, Andrew V. Schally

Publikováno v: Regulatory Peptides. 96:119-124

Growth hormone-releasing hormone (GHRH) is secreted by the hypothalamus and stimulates the release of growth hormone from the pituitary. Recent studies also indicate that in addition to its neuroendocrine function, GHRH may play a direct role in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f97839175b3453d49a38f89b7db35aca
https://doi.org/10.1016/s0167-0115(00)00166-x

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Antagonists of Growth Hormone-Releasing Hormone and Vasoactive Intestinal Peptide Inhibit Tumor Proliferation by Different Mechanisms: Evidence fromin VitroStudies on Human Prostatic and Pancreatic Cancers1

Autor: Andrew V. Schally, Kate Groot, Gabor Halmos, Jozsef L. Varga, Patricia Armatis, Tamas Czompoly, Zoltan Rekasi

Publikováno v: Endocrinology. 141:2120-2128

Antagonists of GH-releasing hormone (GHRH) and vasoactive intestinal peptide (VIP) inhibit the proliferation of various tumors in vitro and in vivo, but a comparison of their antitumor effects and mechanisms of action has not been reported to date. W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::833142a9394593c0a3169f739c431e69
https://doi.org/10.1210/endo.141.6.7511

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Antagonists of growth hormone-releasing hormone (GH-RH) inhibit in vivo proliferation of experimental pancreatic cancers and decrease IGF-II levels in tumours

Autor: Gabor Halmos, Kate Groot, Andrew V. Schally, Patricia Armatis, Karoly Szepeshazi, Francine Hebert

Publikováno v: European Journal of Cancer. 36:128-136

Insulin-like growth factors (IGF-I and IGF-II) are implicated in the pathogenesis of pancreatic carcinoma. Antagonists of growth hormone-releasing hormone (GH-RH) suppress the GH-RH-GH-IGF-I axis and also act directly on tumours to reduce production

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d862ba3b241a76cba7146ebce17f64a
https://doi.org/10.1016/s0959-8049(99)00230-0

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