Zobrazeno 1 - 10
of 162
pro vyhledávání: '"Patricia Andrade-Gordon"'
Autor:
Xinji Guo, PhD, Mikhail A. Kolpakov, MD, PhD, Bahman Hooshdaran, PhD, William Schappell, BS, Tao Wang, MD, PhD, Satoru Eguchi, MD, PhD, Katherine J. Elliott, PhD, Douglas G. Tilley, PhD, A. Koneti Rao, MD, Patricia Andrade-Gordon, PhD, Matthew Bunce, PhD, Chintala Madhu, PhD, Steven R. Houser, PhD, Abdelkarim Sabri, PhD
Publikováno v:
JACC: Basic to Translational Science, Vol 5, Iss 1, Pp 69-83 (2020)
Summary: Activated factor X is a key component of the coagulation cascade, but whether it directly regulates pathological cardiac remodeling is unclear. In mice subjected to pressure overload stress, cardiac factor X mRNA expression and activity incr
Externí odkaz:
https://doaj.org/article/129e8e00131747649c682ca916df38a5
Autor:
Kirstine J Belongie, Ele Ferrannini, Kjell Johnson, Patricia Andrade-Gordon, Michael K Hansen, John R Petrie
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0182932 (2017)
A decline in β-cell function is a prerequisite for the development of type 2 diabetes, yet the level of β-cell function in individuals at risk of the condition is rarely measured. This is due, in part, to the fact that current methods for assessing
Externí odkaz:
https://doaj.org/article/0285894592bb4663a367504ef8fbc14f
Autor:
David Baxter, Markku Laakso, Patricia Andrade-Gordon, Yong Li, Johanna Kuusisto, Kai Wang, Thomas M Connolly, Taek-Kyun Kim, Xiaogang Wu, Vikas Ghai
Publikováno v:
Journal of Cellular and Molecular Medicine
Type 2 Diabetes Mellitus (T2DM) is the most prevalent form of diabetes in the USA, thus, the identification of biomarkers that could be used to predict the progression from prediabetes to T2DM would be greatly beneficial. Recently, circulating RNA in
Autor:
Silvio Antoniak, Saravanan Subramaniam, Michael Bode, Rashi Vora, Patricia Andrade-Gordon, Alyson C. Auriemma, Yohei Hisada, Weeranun D Bode, Nigel Mackman, Steven P. Grover, Alex Rennie, Brian C. Cooley
Publikováno v:
Thrombosis Research. 167:128-134
Introduction Rivaroxaban selectively inhibits factor Xa (FXa), which plays a central role in blood coagulation. In addition, FXa activates protease-activated receptor-2 (PAR-2). We have shown that PAR-2−/− mice exhibit less cardiac dysfunction af
Autor:
Patricia Andrade-Gordon, Kjell Johnson, Kirstine J. Belongie, John R. Petrie, Ele Ferrannini, Michael K. Hansen
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 8, p e0182932 (2017)
PLoS ONE, Vol 12, Iss 8, p e0182932 (2017)
A decline in β-cell function is a prerequisite for the development of type 2 diabetes, yet the level of β-cell function in individuals at risk of the condition is rarely measured. This is due, in part, to the fact that current methods for assessing
Autor:
Patricia Andrade-Gordon, Barbara J. Haertlein, Bruce P. Damiano, Bruce E. Maryanoff, Michael J. Costanzo, Edward C. Giardino, Lawrence de Garavilla
Publikováno v:
Blood Coagulation & Fibrinolysis. 21:128-134
Whereas heparin functions as an antithrombotic agent by promoting antithrombin III-based inhibition of thrombin and factor Xa, there is less appreciation for the combination behavior with small-molecule, direct inhibitors of these proteases. We condu
Publikováno v:
Inflammation Research
Objective Our aim was to determine the contribution of proteinase-activated receptor-2 (PAR2)-expressing bone marrow-derived cells on the development of colonic inflammation. Materials Chimeric mice were generated by injecting bone marrow cells from
Autor:
Florence Schaffner, Lesley G. Ellies, Barbara M. Mueller, Wolfram Ruf, Patricia Andrade-Gordon, Henri H. Versteeg, Marjolein Kerver
Publikováno v:
Cancer Research. 68:7219-7227
The G protein–coupled protease-activated receptors (PAR) are key signaling components for proteases in vascular biology and tumor progression. To address the contributions of PAR1 and PAR2 to breast cancer development, we established cohorts of mou
Autor:
Keith T. Demarest, Wai-man Cheung, Philip J. Rybczynski, Lisa Minor, Bruce P. Damiano, Pamela G. Wines, Tom Jay Parry, Min Xiang, Lawrence de Garavilla, Patricia Andrade-Gordon, Bruce E. Maryanoff, Joseph W. Gunnet
Publikováno v:
European Journal of Pharmacology. 590:333-342
The dysregulation of arginine vasopressin (AVP) release and activation of vasopressin V 1A and V 2 receptors may play a role in disease. The in vitro and in vivo pharmacology of RWJ-676070, a potent, balanced antagonist of both the V 1A and V 2 recep
Publikováno v:
Gut. 57:1222-1229
Background and aims: The role of protease-activated receptor-2 (PAR 2 ) during intestinal inflammation is still unclear due to the fact that PAR 2 -activating peptide has both pro- and anti-inflammatory properties. The aim of this study was to invest