Výsledky vyhledávání - "Patricia Alves de Castro"

Akademický článek

Milteforan, a promising veterinary commercial product against feline sporotrichosis

Autor: Laura C. García Carnero, Camila Figueiredo Pinzan, Camila Diehl, Patricia Alves de Castro, Lais Pontes, Anderson Messias Rodrigues, Thaila F. dos Reis, Gustavo H. Goldman

Publikováno v: Microbiology Spectrum, Vol 12, Iss 10 (2024)

ABSTRACT Sporotrichosis, the cutaneous mycosis most commonly reported in Latin America, is caused by the Sporothrix clinical clade species, including Sporothrix brasiliensis and Sporothrix schenckii sensu stricto. Due to its zoonotic transmission in

Externí odkaz: https://doaj.org/article/45b7e29aca5446329d0472fa64aa8762

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Akademický článek

Aspergillus fumigatus Acetate Utilization Impacts Virulence Traits and Pathogenicity

Publikováno v: mBio, Vol 12, Iss 4 (2021)

ABSTRACT Aspergillus fumigatus is a major opportunistic fungal pathogen of immunocompromised and immunocompetent hosts. To successfully establish an infection, A. fumigatus needs to use host carbon sources, such as acetate, present in the body fluids

Externí odkaz: https://doaj.org/article/0159b3f7f75a4c6cb40eb25bbdc84201

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Akademický článek

Evolutionary origin and population diversity of a cryptic hybrid pathogen

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)

Abstract Cryptic fungal pathogens pose disease management challenges due to their morphological resemblance to known pathogens. Here, we investigated the genomes and phenotypes of 53 globally distributed isolates of Aspergillus section Nidulantes fun

Externí odkaz: https://doaj.org/article/5b9dafe24b2b40d18c7832764b5d79b9

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Akademický článek

Strain heterogeneity in a non-pathogenic Aspergillus fungus highlights factors associated with virulence

Autor: David C. Rinker, Thomas J. C. Sauters, Karin Steffen, Adiyantara Gumilang, Huzefa A. Raja, Manuel Rangel-Grimaldo, Camila Figueiredo Pinzan, Patrícia Alves de Castro, Thaila Fernanda dos Reis, Endrews Delbaje, Jos Houbraken, Gustavo H. Goldman, Nicholas H. Oberlies, Antonis Rokas

Publikováno v: Communications Biology, Vol 7, Iss 1, Pp 1-16 (2024)

Abstract Fungal pathogens exhibit extensive strain heterogeneity, including variation in virulence. Whether closely related non-pathogenic species also exhibit strain heterogeneity remains unknown. Here, we comprehensively characterized the pathogeni

Externí odkaz: https://doaj.org/article/c85380d1268244839d8888e033552685

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Akademický článek

Brilacidin, a host defense peptide mimetic, potentiates ibrexafungerp antifungal activity against the human pathogenic fungus Aspergillus fumigatus

Autor: Thaila Fernanda dos Reis, Camila Diehl, Camila Figueiredo Pinzan, Patrícia Alves de Castro, Gustavo H. Goldman

Publikováno v: Microbiology Spectrum, Vol 12, Iss 8 (2024)

ABSTRACT Aspergillus fumigatus is the primary etiological agent of aspergillosis. Here, we show that the host defense peptide mimetic brilacidin (BRI) can potentiate ibrexafungerp (IBX) against clinical isolates of A. fumigatus. BRI + IBX can inhibit

Externí odkaz: https://doaj.org/article/f26703b665b147d39c6bf4c57affb655

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Akademický článek

Brilacidin, a novel antifungal agent against Cryptococcus neoformans

Publikováno v: mBio, Vol 15, Iss 7 (2024)

ABSTRACT Cryptococcus neoformans causes cryptococcosis, one of the most prevalent fungal diseases, generally characterized by meningitis. There is a limited and not very effective number of drugs available to combat this disease. In this manuscript,

Externí odkaz: https://doaj.org/article/e7e096fb2e1e45db88ee688644d28cb3

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Akademický článek

Aspergillus fumigatus mitogen-activated protein kinase MpkA is involved in gliotoxin production and self-protection

Autor: Patrícia Alves de Castro, Camila Figueiredo Pinzan, Thaila Fernanda dos Reis, Clara Valero, Norman Van Rhijn, Carla Menegatti, Ivan Lucas de Freitas Migliorini, Michael Bromley, Alastair B. Fleming, Aimee M. Traynor, Özlem Sarikaya-Bayram, Özgür Bayram, Iran Malavazi, Frank Ebel, Júlio César Jerônimo Barbosa, Taícia Fill, Monica Tallarico Pupo, Gustavo H. Goldman

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)

Abstract Aspergillus fumigatus is a saprophytic fungus that can cause a variety of human diseases known as aspergillosis. Mycotoxin gliotoxin (GT) production is important for its virulence and must be tightly regulated to avoid excess production and

Externí odkaz: https://doaj.org/article/1fe2f63fd7f8410dbf26ab5e774b6588

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Akademický článek

A host defense peptide mimetic, brilacidin, potentiates caspofungin antifungal activity against human pathogenic fungi

Autor: Thaila Fernanda dos Reis, Patrícia Alves de Castro, Rafael Wesley Bastos, Camila Figueiredo Pinzan, Pedro F. N. Souza, Suzanne Ackloo, Mohammad Anwar Hossain, David Harold Drewry, Sondus Alkhazraji, Ashraf S. Ibrahim, Hyunil Jo, Jorge D. Lightfoot, Emily M. Adams, Kevin K. Fuller, William F. deGrado, Gustavo H. Goldman

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)

Abstract Fungal infections cause more than 1.5 million deaths a year. Due to emerging antifungal drug resistance, novel strategies are urgently needed to combat life-threatening fungal diseases. Here, we identify the host defense peptide mimetic, bri

Externí odkaz: https://doaj.org/article/95f2a58a934d446abc7358a90c1dec91

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Akademický článek

Transcriptional profiling of a fungal granuloma reveals a low metabolic activity of Paracoccidioides brasiliensis yeasts and an actively regulated host immune response

Autor: Bruno Montanari Borges, Rafael Berton Correia Ramos, Nycolas Willian Preite, Valéria de Lima Kaminski, Patrícia Alves de Castro, Maurício Camacho, Marina Ferreira Maximo, Taicia Pacheco Fill, Vera Lúcia Garcia Calich, Aimee M. Traynor, Özlem Sarikaya-Bayram, Sean Doyle, Özgür Bayram, Claudia Barbosa Ladeira de Campos, André Zelanis, Gustavo H. Goldman, Flávio Vieira Loures

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)

Granulomas are important immunological structures in the host defense against the fungus Paracoccidioides brasiliensis, the main etiologic agent of Paracoccidioidomycosis (PCM), a granulomatous systemic mycosis endemic in Latin America. We have perfo

Externí odkaz: https://doaj.org/article/68a73958ff004898a97f1b937a00e98a

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