Evaluation of the elastinolytic activity and protective effect of Leptallo I, a protein composed by metalloprotease and FA5/8C domains, from Leptospira interrogans Copenhageni

Autor: V.L. Hashimoto, Amane Paldês Gonçales, Eliete Caló Romero, Paulo Lee Ho, Eneas Carvalho, Silvio Arruda Vasconcellos, Patricia Ae Abreu, Zenaide Maria de Morais

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Leptospirosis is a re-emergent zoonosis, caused by pathogenic spirochetes from the genus Lepstospira. To date, there is no protein described to be involved in leptospiral hemorrhagic manifestations, although several proteases have been reported for o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6970849f312cbd8547e8ead8555c6d3a

Lsa21, a novel leptospiral protein binding adhesive matrix molecules and present during human infection

Autor: Dirce Mc Lima, Patricia Ae Abreu, Marina V. Atzingen, Silvio Arruda Vasconcellos, Ana L. T. O. Nascimento, Thales de Brito, Zenaide Maria de Morais, Angela Silva Barbosa

Publikováno v: BMC Microbiology, Vol 8, Iss 1, p 70 (2008)
BMC Microbiology
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Background It has been well documented over past decades that interaction of pathogens with the extracellular matrix (ECM) plays a primary role in host cell attachment and invasion. Adherence to host tissues is mediated by surface-exposed proteins ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59f61e5474476e75e99fb6aa4507386c
http://www.biomedcentral.com/1471-2180/8/70