Complexation of the Antihypertensive Drug Olmesartan with Zn: In Vivo Antihypertensive and Cardiac Effects

Autor: Andrés G. Restrepo Guerrero, Valeria R. Martinez, Jorge O. Velez Rueda, Enrique L. Portiansky, Verónica De Giusti, Evelina G. Ferrer, Patricia A.M Williams

Publikováno v: Biological Trace Element Research.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::853efb031c20559c6982bb641221418d
https://doi.org/10.1007/s12011-023-03670-8

Improvement of the Anticancer Activities of Telmisartan by Zn(II) Complexation and Mechanisms of Action

Autor: Juan Santiago Todaro, Patricia A.M. Williams, Evelina G. Ferrer, María Victoria Aguirre, Valeria R. Martínez

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

To improve the anticancer activity of telmisartan, its structure has been modified by Zn(II) complexation giving [Zn(Telm)2(H2O)2]·2H2O (ZnTelm). The cytotoxic effect was measured on the human lung cancer cells (A549) and on the lung fibroblast cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d150be257e6f621d82afb6c77263ff2
https://doi.org/10.1007/s12011-019-02013-w

Synthesis, characterization, theoretical studies and biological (antioxidant, anticancer, toxicity and neuroprotective) determinations of a copper(II) complex with 5-hydroxytryptophan

Autor: María Valcárcel, Clarisa Salado, Juan José Martínez Medina, Alberto Claudio Rizzi, Patricia A.M. Williams, Ana Laura Pérez, Luciana G. Naso, Evelina G. Ferrer, Nora Beatriz Okulik

Publikováno v: Biomedicine & Pharmacotherapy, Vol 111, Iss, Pp 414-426 (2019)
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

5-Hydroxy-L-tryptophan (5-HTP) is a serotonin pathway metabolite of L-tryptophan in the brain. In the knowledge that the biological properties of some compounds can be modified upon metal complexation, a new solid metal complex, [Cu(5-hydroxytryptoph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7009c3cac8d7e1277c4296a998ed4bc
https://doi.org/10.1016/j.biopha.2018.12.098

In vitroexperiments and infrared spectroscopy analysis of acid and alkaline phosphatase inhibition by vanadium complexes

Autor: Juliana Elena Parente, Luciana G. Naso, Carlos A. Franca, Evelina G. Ferrer, Patricia A.M. Williams, Ana Maria da Costa Ferreira, Khalil Jori

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

In the course of our research on vanadium-containing complexes, two oxidovanadium complexes containing vanadium(V) and (IV) cores with 4-aminobenzoic acid and/or the peroxo anion as ligands were synthesized and characterized by elemental analysis, co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2644fc1e5a151ff0f5a5df7582670cb4
https://doi.org/10.1039/c9nj01638d

Antifungal, phyto, cyto, genotoxic and lipophilic properties of three complexes of sulfadimethoxine (HSDM) with Ag(I). Synthesis and characterization of [Ag3SDM(SCN)2]·H2O and [Ag2(SDM)2o-phenanthroline]·H2O

Autor: Laura L. Monti, Cecilia Giulidori, Sebastián Bellú, Patricia A.M. Williams, Marcela Patricia Raimondi, Natalia Mosconi, Marcela Rizzotto

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Fungal infections are still a major problem. Some limitations of current antifungals (toxicity, fungal resistance) require the search for new drugs. The interest in metal–sulfanilamide derivatives was stimulated by the successful introduction of a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fd641ac187319273dd739888e332649
https://www.sciencedirect.com/science/article/abs/pii/S0277538720306227