Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Patricia A.J. Muller"'
Autor:
Sara Zanivan, Eduardo Nagore, Katharina Roeck, Victor Traves, Patricia A.J. Muller, Angeliki Malliri, Emily J. Kay, Luisa Motta, Andrew P. Porter, Amaya Viros, Simon J Furney, Caroline Gaudy-Marqueste, Shilpa Gurung, Charles H. Earnshaw, Jean Krutmann, Sarah Craig, Timothy Budden
Publikováno v:
Budden, T, Gaudy-Marqueste, C, Porter, A, Kay, E, Gurung, S, Earnshaw, C H, Roeck, K, Craig, S, Traves, V, Krutmann, J, Muller, P, Motta, L, Zanivan, S, Malliri, A, Furney, S J, Nagore, E & Virós, A 2021, ' Ultraviolet light-induced collagen degradation inhibits melanoma invasion ', Nature Communications, vol. 12, no. 1, 2742 . https://doi.org/10.1038/s41467-021-22953-z
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Ultraviolet radiation (UVR) increases the incidence of cutaneous melanoma1–4. The ageing, sun-exposed dermis accumulates UVR damage5, and older patients develop more melanomas at UVR-exposed sites4,6,7. As fibroblasts are functionally heterogeneous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::071297cecab6a5af770da7b7117ab089
https://eprints.gla.ac.uk/241457/1/241457.pdf
https://eprints.gla.ac.uk/241457/1/241457.pdf
Autor:
Patricia A.J. Muller, Caroline Dive, Callum Hall, S. Bagley, Simon P. Pearce, Y. von Grabowiecki
Publikováno v:
Cancer Cell International
Hall, C, Grabowiecki, Y V, Pearce, S P, Dive, C, Bagley, S & Muller, P A J 2021, ' iRFP (near-infrared fluorescent protein) imaging of subcutaneous and deep tissue tumours in mice highlights differences between imaging platforms ', Cancer Cell International, vol. 21, no. 1, 247 . https://doi.org/10.1186/s12935-021-01918-8
Cancer Cell International, Vol 21, Iss 1, Pp 1-15 (2021)
Hall, C, Grabowiecki, Y V, Pearce, S P, Dive, C, Bagley, S & Muller, P A J 2021, ' iRFP (near-infrared fluorescent protein) imaging of subcutaneous and deep tissue tumours in mice highlights differences between imaging platforms ', Cancer Cell International, vol. 21, no. 1, 247 . https://doi.org/10.1186/s12935-021-01918-8
Cancer Cell International, Vol 21, Iss 1, Pp 1-15 (2021)
Background In vivo imaging using fluorescence is used in cancer biology for the detection, measurement and monitoring of tumours. This can be achieved with the expression of fluorescent proteins such as iRFP, which emits light at a wavelength less at
Autor:
Patricia A.J. Muller, Hannah L. Mackay
Publikováno v:
Biochemical Society Transactions
Cell-in-cell (CIC) is a term used to describe the presence of one, usually living, cell inside another cell that is typically considered non-phagocytic. Examples of this include tumour cells inside tumour cells (homotypic), mesenchymal stem cells ins
Autor:
Callum Hall, Patricia A.J. Muller
Publikováno v:
Hall, C & Muller, P 2019, ' The Diverse Functions of Mutant 53, Its Family Members and Isoforms in Cancer ', International Journal of Molecular Sciences . https://doi.org/10.3390/ijms20246188
International Journal of Molecular Sciences
International Journal of Molecular Sciences
The p53 family of proteins has grown substantially over the last 40 years. It started with p53, then p63, p73, isoforms and mutants of these proteins. The function of p53 as a tumour suppressor has been thoroughly investigated, but the functions of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79b0d8023bfc7a5a6d10d0a10ee219e0
https://research.manchester.ac.uk/en/publications/00bcf5c9-4038-4584-99e7-4b751c98fd71
https://research.manchester.ac.uk/en/publications/00bcf5c9-4038-4584-99e7-4b751c98fd71
Autor:
Chang Gok Woo, Hui Jeong Jeong, Richard Bayliss, Giancarlo Barone, Jene Choi, Spencer J. Collis, Patricia A.J. Muller, Dean A. Fennell, Emily L. Richardson, Rozita Adib, Laura O'Regan, Mark W. Richards, Andrew M. Fry
Publikováno v:
J Cell Sci
EML4–ALK is an oncogenic fusion present in ∼5% of non-small cell lung cancers. However, alternative breakpoints in the EML4 gene lead to distinct variants of EML4–ALK with different patient outcomes. Here, we show that, in cell models, EML4–A
Autor:
Jene Choi, Patricia A.J. Muller, Spencer J. Collis, Rozita Adib, Mark W. Richards, Hui Jeong Jeong, Emily L. Richardson, Richard Bayliss, Laura O'Regan, Chang Gok Woo, Dean A. Fennell, Giancarlo Barone, Andrew M. Fry
Publikováno v:
SSRN Electronic Journal.
EML4-ALK is an oncogenic fusion present in ∼5% lung adenocarcinomas. However, distinct EML4-ALK variants differ in the length of the EML4 microtubule-associated protein encoded within the fusion and are associated with a poorly understood variabili
Autor:
Patricia A.J. Muller, Lydia Aschauer
Publikováno v:
Biochemical Society Transactions. 44:460-466
In many human cancers p53 expression is lost or a mutant p53 protein is expressed. Over the past 15 years it has become apparent that a large number of these mutant p53 proteins have lost wild type function, but more importantly have gained functions
Autor:
Hannah L. Mackay, David Moore, Saadia A. Karim, Lucia Piñon, Callum Hall, Patricia A.J. Muller, John Le Quesne, Mariam Jamal-Hanjani, Jennifer P. Morton, Vinaya M. Phatak, Nicolai Juul Birkbak, Charles Swanton
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)
Nature Communications
Nature Communications
Cell-in-cell (CIC) structures are commonly seen in tumours. Their biological significance remains unclear, although they have been associated with more aggressive tumours. Here we report that mutant p53 promotes CIC via live cell engulfment. Engulfed
Autor:
Saadia A. Karim, Hannah L. Mackay, David Moore, John Le Quesne, Mariam Jamal-Hanjani, Nicolai Juul Birkbak, Patricia A.J. Muller, Jennifer P. Morton, Callum Hall, Vinaya M. Phatak, Lucia Piñon, Charles Swanton
Publikováno v:
Mackay, H L, Moore, D, Hall, C, Birkbak, N J, Jamal-Hanjani, M, Karim, S A, Phatak, V M, Piñon, L, Morton, J P, Swanton, C, Le Quesne, J & Muller, P A J 2018, ' Genomic instability in mutant p53 cancer cells upon entotic engulfment ', Nature Communications, vol. 9, no. 1, 3070 . https://doi.org/10.1038/s41467-018-05368-1
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Cell-in-cell (CIC) structures are commonly seen in tumours. Their biological significance remains unclear, although they have been associated with more aggressive tumours. Here we report that mutant p53 promotes CIC via live cell engulfment. Engulfed
Publikováno v:
Biomedicines
Muller, P & Viticchiè, G 2015, ' c-Met and other cell surface molecules ; interaction, activation and functional consequences ', Biomedicines, vol. 3, no. 1 . https://doi.org/10.3390/biomedicines3010046
Biomedicines, Vol 3, Iss 1, Pp 46-70 (2015)
Muller, P & Viticchiè, G 2015, ' c-Met and other cell surface molecules ; interaction, activation and functional consequences ', Biomedicines, vol. 3, no. 1 . https://doi.org/10.3390/biomedicines3010046
Biomedicines, Vol 3, Iss 1, Pp 46-70 (2015)
The c-Met receptor, also known as the HGF receptor, is one of the most studied tyrosine kinase receptors, yet its biological functions and activation mechanisms are still not fully understood. c-Met has been implicated in embryonic development and or