Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Patricia A. Walicke"'
Autor:
Patricia A. Walicke, Franz Hefti, Roxanne Bales, Shiao-Ping Lu, Jon L. Ruckle, Mark T. Brown, Christine R. West, David L. Shelton
Publikováno v:
PAIN Reports, Vol 3, Iss 3, p e653 (2018)
Abstract. Introduction:. The neurotrophin nerve growth factor has a demonstrated role in pain transduction and pathophysiology. Objectives:. Two randomized, double-blind, placebo-controlled, phase 1 studies were conducted to evaluate safety, tolerabi
Externí odkaz:
https://doaj.org/article/a23e1a0f593f4e798fc68720c1f36903
Autor:
David L. Shelton, Shiao-Ping Lu, Roxanne Bales, Mark T. Brown, Patricia Ann Walicke, Jon L Ruckle, Franz F. Hefti, Christine R. West
Publikováno v:
PAIN Reports, Vol 3, Iss 3, p e653 (2018)
Introduction:. The neurotrophin nerve growth factor has a demonstrated role in pain transduction and pathophysiology. Objectives:. Two randomized, double-blind, placebo-controlled, phase 1 studies were conducted to evaluate safety, tolerability, and
Autor:
Alan Menter, Patricia A. Walicke, Ivor Caro, Scott Fretzin, Kenneth B. Gordon, Steven Kempers, Bernard S. Goffe, Reni Bressinck, Kim A. Papp, Xiaolin Wang
Publikováno v:
International Journal of Dermatology. 45:605-614
Background To provide safety data for efalizumab, a recombinant humanized monoclonal IgG1 antibody, in adults with chronic plaque psoriasis. Methods A 12-week, Phase IIIb, randomized, double-blind, parallel-group, placebo-controlled trial. At 58 stud
Autor:
Peter Compton, Mark Lebwohl, David M. Pariser, Kenneth B. Gordon, Amy Chen Rundle, Patricia A. Walicke, Kim A. Papp, Paul Kwon, Craig L. Leonardi
Publikováno v:
Journal of Cutaneous Medicine and Surgery. 9:303-312
Background: Effective psoriasis therapies are needed for long-term symptom control. ObjectiveAssess efalizumab (Raptiva®) efficacy in a large cohort of psoriasis patients. Methods: Data from three Phase III, randomized, double-blind, parallel-group,
Autor:
Kim A. Papp, Charles Camisa, Alice B. Gottlieb, Xiaolin Wang, Stephen P. Stone, Ivor Caro, Patricia A. Walicke, Peter Compton
Publikováno v:
Journal of Cutaneous Medicine and Surgery. 9:313-323
Background: The efficacy and safety of efalizumab have been evaluated in multiple clinical trials. ObjectiveThe purpose of this review is to provide an overview of the safety profile of efalizumab during the clinical trials. Methods: Twelve-week data
Autor:
Peter Compton, Ivor Caro, Steven R. Feldman, Kim A. Papp, Alice B. Gottlieb, Alan Menter, Patricia A. Walicke, Craig L. Leonardi, Kenneth B. Gordon
Publikováno v:
Journal of the American Academy of Dermatology. 52:425-433
Efalizumab inhibits multiple T-cell-mediated processes.To evaluate 12- and 24-week efalizumab therapy for psoriasis.In this phase III, randomized, double-blind trial, 498 patients received subcutaneous 1 or 2 mg/kg/wk efalizumab or placebo for 12 wee
Autor:
Alice B. Gottlieb, Patricia A. Walicke, Nicholas J. Lowe, Ross Bright, Robert J. Bauer, Charles Hudson, Toivo Rist, Anna Magee, Wolfgang Dummer, Mark White, William Shapiro, Bruce E. Miller, Marvin Garovoy, Calvin O. McCall, Mark Ling
Publikováno v:
Journal of Cutaneous Medicine and Surgery. 7:198-207
Background: Phase I and Phase II studies in patients with moderate to severe plaque psoriasis demonstrated that intravenous (TV) efalizumab improved clinical signs and symptoms and was well tolerated. Objective: To determine if subcutaneous (SC) deli
Publikováno v:
Transplant Immunology. 9:181-186
The acquired immune response that leads to graft rejection depends on regulated adhesive interactions between T lymphocytes, endothelial cells, dendritic cells, graft tissue and the extracellular matrix to coordinate cellular trafficking and activati
Autor:
Harvey Lui, Russell L. Dedrick, Neil H. Shear, Mark White, Kim A. Papp, Charles Lynde, Wayne Gulliver, Wayne Carey, Robert Bissonnette, Robert J. Bauer, David Gratton, Marvin Garovoy, Sun Sook Kim, James G. Krueger, Susan M. Kramer, Jerry Shapiro, Daniel Minier, Piyush M. Patel, Patricia A. Walicke, Jean P. Ouellet, Anna Magee
Publikováno v:
Journal of the American Academy of Dermatology. 45:665-674
Anti-CD11a (hu1124) is a humanized monoclonal antibody directed against the CD11a subunit of LFA-1. This study investigated whether treatment with anti-CD11a antibody provides clinical benefit to patients with moderate to severe plaque psoriasis.This
Autor:
Franz Hefti, Patricia Ann Walicke, Jasna Jerecic, Grant A. Krafft, Kent S. Iverson, William F. Goure
Publikováno v:
Alzheimer's & Dementia. 9