Výsledky vyhledávání - "Patricia A. Thistlethwaite"

Akademický článek

Apelin modulates inflammation and leukocyte recruitment in experimental autoimmune encephalomyelitis

Autor: Hongryeol Park, Jian Song, Hyun-Woo Jeong, Max L. B. Grönloh, Bong Ihn Koh, Esther Bovay, Kee-Pyo Kim, Luisa Klotz, Patricia A. Thistlethwaite, Jaap D. van Buul, Lydia Sorokin, Ralf H. Adams

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)

Abstract Demyelination due to autoreactive T cells and inflammation in the central nervous system are principal features of multiple sclerosis (MS), a chronic and highly disabling human disease affecting brain and spinal cord. Here, we show that trea

Externí odkaz: https://doaj.org/article/73b6422aec3343758220e17b6a05df69

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Akademický článek

Mouse model of experimental pulmonary hypertension: Lung angiogram and right heart catheterization

Publikováno v: Pulmonary Circulation, Vol 11, Iss 4, Pp 1-17 (2021)

Pulmonary arterial hypertension is a progressive and fatal disease and rodents with experimental pulmonary hypertension (PH) are often used to study pathogenic mechanisms, identify therapeutic targets, and develop novel drugs for treatment. Here we d

Externí odkaz: https://doaj.org/article/1cc8dfb4cf714cbb804698ca95dfda41

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Akademický článek

Upregulation of Calcium Homeostasis Modulators in Contractile-To-Proliferative Phenotypical Transition of Pulmonary Arterial Smooth Muscle Cells

Publikováno v: Frontiers in Physiology, Vol 12 (2021)

Excessive pulmonary artery (PA) smooth muscle cell (PASMC) proliferation and migration are implicated in the development of pathogenic pulmonary vascular remodeling characterized by concentric arterial wall thickening and arteriole muscularization in

Externí odkaz: https://doaj.org/article/1995a8a050974260b9221a472c8505e7

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Akademický článek

Revisiting the mechanism of hypoxic pulmonary vasoconstriction using isolated perfused/ventilated mouse lung

Autor: Pritesh P. Jain, Susumu Hosokawa, Mingmei Xiong, Aleksandra Babicheva, Tengteng Zhao, Marisela Rodriguez, Shamin Rahimi, Kiana Pourhashemi, Francesca Balistrieri, Ning Lai, Atul Malhotra, John Y.-J. Shyy, Daniela Valdez-Jasso, Patricia A. Thistlethwaite, Ayako Makino, Jason X.-J. Yuan

Publikováno v: Pulmonary Circulation, Vol 10 (2020)

Hypoxic Pulmonary Vasoconstriction (HPV) is an important physiological mechanism of the lungs that matches perfusion to ventilation thus maximizing O 2 saturation of the venous blood within the lungs. This study emphasizes on principal pathways in th

Externí odkaz: https://doaj.org/article/d3f232845d024d048532b4afcc9a8108

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Akademický článek

Endothelial platelet-derived growth factor-mediated activation of smooth muscle platelet-derived growth factor receptors in pulmonary arterial hypertension

Publikováno v: Pulmonary Circulation, Vol 10 (2020)

Platelet-derived growth factor is one of the major growth factors found in human and mammalian serum and tissues. Abnormal activation of platelet-derived growth factor signaling pathway through platelet-derived growth factor receptors may contribute

Externí odkaz: https://doaj.org/article/e8aacfe17c21472f9cda3af4d960ce7d

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Akademický článek

Adult stem cell-derived complete lung organoid models emulate lung disease in COVID-19

Publikováno v: eLife, Vol 10 (2021)

Background: SARS-CoV-2, the virus responsible for COVID-19, causes widespread damage in the lungs in the setting of an overzealous immune response whose origin remains unclear. Methods: We present a scalable, propagable, personalized, cost-effective

Externí odkaz: https://doaj.org/article/a2f6ea2e6df643eab8feb143e8860634

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Iatrogenic intrathoracic encapsulated siliconoma from a ruptured breast implant

Autor: Christina Shree Chopra, Fernando A. Herrera, Ahmed Suliman, Patricia A. Thistlethwaite

Publikováno v: BMJ case reports. 14(9)

Our patient was a 57-year-old woman with a history of bilateral retropectoral silicone breast augmentation and axillary hyperhidrosis who underwent a bilateral thoracic sympathectomy via video-assisted thoracoscopic surgery by a surgeon at an outside

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a7fcfc577b2023c39180dcfc6f9d4ca
https://pubmed.ncbi.nlm.nih.gov/34497056

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Mechanosensitive cation currents through TRPC6 and Piezo1 channels in human pulmonary arterial endothelial cells

Autor: Tengteng Zhao, Sophia Parmisano, Zahra Soroureddin, Manjia Zhao, Lauren Yung, Patricia A. Thistlethwaite, Ayako Makino, Jason X.-J Yuan

Publikováno v: American Journal of Physiology-Cell Physiology. 323:C959-C973

Mechanosensitive cation channels and Ca2+ influx through these channels play an important role in the regulation of endothelial cell functions. Transient receptor potential canonical channel 6 (TRPC6) is a diacylglycerol-sensitive nonselective cation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a676d1291fa4fdda4347371a7ec6f243
https://doi.org/10.1152/ajpcell.00313.2022

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