Zobrazeno 1 - 9
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pro vyhledávání: '"Patricia A. Soucy"'
Autor:
Kelsey Kinney, Martin G. O’Toole, Patricia A. Soucy, Archana Akalkotkar, Robert S. Keynton, Rajat Chauhan, Betty M. Nunn
Publikováno v:
RSC Advances. 10:16110-16117
The probability of human exposure to damaging radiation is increased in activities associated with long-term space flight, medical radiation therapies, and responses to nuclear accidents. However, the development of responsive countermeasures to comb
Autor:
Robert S. Keynton, Andrea S. Gobin, William D. Ehringer, Richard M. Henderson, Martin G. O’Toole, Patrick J. Hoblitzell, Brigitte H. Fasciotto, Patricia A. Soucy
Publikováno v:
Biomacromolecules. 13:2309-2314
Optimal curcumin delivery for medicinal applications requires a drug delivery system that both solubilizes curcumin and prevents degradation. To achieve this, curcumin has been encapsulated in submicrometer chitosan/Tween 20 particles via a benchtop
Autor:
Patricia A. Soucy, Raghav Ramachandran, David O. Attarzadeh, Kevin G. Soucy, Lewis H. Romer, Dan E. Berkowitz, Artin A. Shoukas
Publikováno v:
Radiation and Environmental Biophysics. 49:397-404
Radiation exposure can increase the risk for many non-malignant physiological complications, including cardiovascular disease. We have previously demonstrated that ionizing radiation can induce endothelial dysfunction, which contributes to increased
Autor:
Wolfgang Zacharias, Patricia A. Soucy, Sabine Waigel, Howard Donninger, Geoffrey J. Clark, Vennila Arumugam, Leah J. Siskind, Levi J. Beverly, Michael T. Scherzer
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0138065 (2015)
PLoS ONE
PLoS ONE
Poor survival rates from lung cancer can largely be attributed to metastatic cells that invade and spread throughout the body. The tumor microenvironment (TME) is composed of multiple cell types, as well as non-cellular components. The TME plays a cr
Publikováno v:
Acta biomaterialia. 11
Detailed control over the structural organization of scaffolds and engineered tissue constructs is a critical need in the quest to engineer functional tissues using biomaterials. This work presents a new approach to the spatial direction of endotheli
Publikováno v:
ASME 2013 2nd Global Congress on NanoEngineering for Medicine and Biology.
Triple-negative breast cancer (TNBC) accounts for ∼25% of breast cancer among premenopausal African-American and Latino women1. Curcumin (diferuloylmethane; CCM), a natural polyphenol extracted from turmeric, has chemopreventive and chemotherapeuti
Autor:
William D. Ehringer, Martin G. O’Toole, Andrea S. Gobin, Patricia M. Soucy, Robert S. Keynton, Brigette H. Totten, Patrick G. Hoblitzell
Publikováno v:
Biophysical Journal. 102(3)
Curcumin is an extract of turmeric, and is an effective reactive oxygen species scavenger, with potential anti-cancer benefits. In this study, we examined the effects of curcumin on membrane bilayer permeability, fusion, anisotropy, hydrodynamic radi
Publikováno v:
Acta biomaterialia. 7(1)
The mechanical properties of the extracellular microenvironment regulate cell behavior, including migration, proliferation and morphogenesis. Although the elastic moduli of synthetic materials have been studied, little is known about the properties o
Autor:
Patricia A. Soucy, Lewis H. Romer
Publikováno v:
Matrix biology : journal of the International Society for Matrix Biology. 28(5)
Extracellular matrix plays a critical role in cellular development by providing signaling cues that direct morphogenesis. In order to study both the cues that natural matrix provides and endothelial cell responses to that information, human fetal lun