Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Patricia A. Olofsen"'
Publikováno v:
Cells, Vol 12, Iss 15, p 1981 (2023)
Neutrophils are crucial innate immune cells and comprise 50–70% of the white blood cell population under homeostatic conditions. Upon infection and in cancer, blood neutrophil numbers significantly increase because of the secretion of various chemo
Externí odkaz:
https://doaj.org/article/7d448eff74d44cc8abbf9e923b0bbbf8
Autor:
Patricia A. Olofsen, Marjolein C. Stip, J. H. Marco Jansen, Chilam Chan, Maaike Nederend, Ralph G. Tieland, Maria Tsioumpekou, Jeanette H. W. Leusen
Publikováno v:
Cells, Vol 11, Iss 21, p 3406 (2022)
Neutrophils are crucial innate immune cells but also play key roles in various diseases, such as cancer, where they can perform both pro- and anti-tumorigenic functions. To study the function of neutrophils in vivo, these cells are often depleted usi
Externí odkaz:
https://doaj.org/article/5c5e23c225514b3eb3afc308958c4d80
Autor:
Patricia A. Olofsen, Szabolcs Fatrai, Paulina M.H. van Strien, Julia C. Obenauer, Hans W.J. de Looper, Remco M. Hoogenboezem, Claudia A.J. Erpelinck-Verschueren, Michael P.W.M. Vermeulen, Onno Roovers, Torsten Haferlach, Joop H. Jansen, Mehrnaz Ghazvini, Eric M.J. Bindels, Rebekka K. Schneider, Emma M. de Pater, Ivo P. Touw
Publikováno v:
Cell Reports Medicine, Vol 1, Iss 5, Pp 100074- (2020)
Summary: Severe congenital neutropenia (SCN) patients treated with CSF3/G-CSF to alleviate neutropenia frequently develop acute myeloid leukemia (AML). A common pattern of leukemic transformation involves the appearance of hematopoietic clones with C
Externí odkaz:
https://doaj.org/article/a0e7d0f08d2e4c29ae248feba801718a
Autor:
Patricia A. Olofsen, Dennis A. Bosch, Hans W. J. de Looper, Paulina M. H. van Strien, Remco M. Hoogenboezem, Onno Roovers, Vincent H. J. van der Velden, Eric M. J. Bindels, Emma M. De Pater, Ivo P. Touw
Publikováno v:
British Journal of Haematology, 200(1), 79-86. Wiley-Blackwell Publishing Ltd
Severe congenital neutropenia (SCN) patients are prone to develop myelodysplastic syndrome (MDS) or acute myeloid leukaemia (AML). Leukaemic progression of SCN is associated with the early acquisition of CSF3R mutations in haematopoietic progenitor c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::315da5a6237131896968a5e8a5195dfa
http://www.scopus.com/inward/record.url?scp=85138749245&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85138749245&partnerID=8YFLogxK
Secondary CNL after SAA reveals insights in leukemic transformation of bone marrow failure syndromes
Autor:
Alexandar Tzankov, Pontus Lundberg, Martina Kleber, Jakob Passweg, Mario Uhr, Joerg Halter, Ivo P. Touw, Laurent Schmied, Beatrice Drexler, Patricia A. Olofsen, Peter J. M. Valk
Publikováno v:
Blood Adv
Blood advances, 4(21), 5540-5546. American Society of Hematology
Blood advances, 4(21), 5540-5546. American Society of Hematology
Acquired aplastic anemia and severe congenital neutropenia (SCN) are bone marrow (BM) failure syndromes of different origin, however, they share a common risk for secondary leukemic transformation. Here, we present a patient with severe aplastic anem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4dfa66ac448066f7bb6480ef4dc89ae
https://doi.org/10.1182/bloodadvances.2020001541
https://doi.org/10.1182/bloodadvances.2020001541
Autor:
Jacques Stoelben, Si Chen, Almira Henic, Patricia A. Olofsen, Ursula S.A. Stalmann, Mónica S. Ventura Ferreira, Uwe Platzbecker, Benjamin L. Ebert, Rafael Kramann, Remco Hoogenboezem, Guntram Buesche, Marc H.G.P. Raaijmakers, Susanne Ziegler, Flavia Ribezzo, Rebekka K. Schneider, Inge A.M. Snoeren
Publikováno v:
Leukemia, 33(7), 1759-1772. Nature Publishing Group
Leukemia
Leukemia
RPS14, CSNK1A1, and miR-145 are universally co-deleted in the 5q- syndrome, but mouse models of each gene deficiency recapitulate only a subset of the composite clinical features. We analyzed the combinatorial effect of haploinsufficiency for Rps14,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f00a30bfe2c73925297e368453d349b6
https://hdl.handle.net/1765/118267
https://hdl.handle.net/1765/118267
Autor:
Cinzia Allegrucci, Amerikos Argyriou, Jérôme Caron, Hoi-Hung Cheung, Daria S. Chulpanova, M. Csobonyeiová, Anne Dubart-Kupperschmitt, Rachel Eiges, Jingping Ge, Kaomei Guan, Riikka H. Hämäläinen, Tayma Handal, Kristina V. Kitaeva, Jiesi Luo, Shalem R. Modi, Aysilu I. Mullagulova, George P. Murphy, Katie Newman, Patricia A. Olofsen, Mareike S. Poetsch, Owen M. Rennert, Albert A. Rizvanov, Ponlapat Rojnuckarin, Alisa A. Shaimardanova, Valeriya V. Solovyeva, Martin H. Steinberg, Ivo P. Touw, Kim Vanuytsel, Tao Wang, Anne Weber
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3bb09dbf2a35c77efcc9d4bb35855ad6
https://doi.org/10.1016/b978-0-12-822227-0.01002-4
https://doi.org/10.1016/b978-0-12-822227-0.01002-4
Autor:
Mehrnaz Ghazvini, Eric M.J. Bindels, Ivo P. Touw, Paulina M. H. van Strien, Vincent H.J. van der Velden, Remco Hoogenboezem, Dennis Bosch, Pier G. Mastroberardino, Emma de Pater, Hans de Looper, Onno Roovers, Sander Barnhoorn, Patricia A. Olofsen
Publikováno v:
Blood Adv
Blood advances, 5(3), 775-786. American Society of Hematology
Blood advances, 5(3), 775-786. American Society of Hematology
Mutations in ELANE cause severe congenital neutropenia (SCN), but how they affect neutrophil production and contribute to leukemia predisposition is unknown. Neutropenia is alleviated by CSF3 (granulocyte colony-stimulating factor) therapy in most ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68f08ea678a32baf8533b2f0251fb3d0
https://pubmed.ncbi.nlm.nih.gov/33560392
https://pubmed.ncbi.nlm.nih.gov/33560392
Autor:
Ivo P. Touw, Patricia A. Olofsen
Publikováno v:
Recent Advances in iPSC Disease Modeling, 1, 85-101
Patients with severe congenital neutropenia (SCN) suffer from a severe shortage of neutrophilic granulocytes, leading to life-threatening bacterial infections. The severe neutropenia and infectious episodes can be alleviated by life-long treatment wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fddd4ad272f3c13575643074584066d0
https://pure.eur.nl/en/publications/c3ad1996-94db-4c1e-8875-e9ccc6623c26
https://pure.eur.nl/en/publications/c3ad1996-94db-4c1e-8875-e9ccc6623c26
Autor:
Ivo P. Touw, Onno Roovers, Torsten Haferlach, Eric M.J. Bindels, Julia C. Obenauer, Emma de Pater, Szabolcs Fatrai, Remco Hoogenboezem, Rebekka K. Schneider, Paulina M. H. van Strien, Hans de Looper, Mehrnaz Ghazvini, Michael P.W.M. Vermeulen, Claudia A.J. Erpelinck-Verschueren, Joop H. Jansen, Patricia A. Olofsen
Publikováno v:
Cell Reports Medicine, 1, 5
Cell Reports Medicine, 1
Cell Reports Medicine, 1(5):100074. Cell Press
Cell Reports Medicine
Cell Reports Medicine, Vol 1, Iss 5, Pp 100074-(2020)
Cell Reports Medicine, 1
Cell Reports Medicine, 1(5):100074. Cell Press
Cell Reports Medicine
Cell Reports Medicine, Vol 1, Iss 5, Pp 100074-(2020)
Summary Severe congenital neutropenia (SCN) patients treated with CSF3/G-CSF to alleviate neutropenia frequently develop acute myeloid leukemia (AML). A common pattern of leukemic transformation involves the appearance of hematopoietic clones with CS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8e8185773d4b782f90b97173a3e346d
https://hdl.handle.net/2066/229624
https://hdl.handle.net/2066/229624