Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Patricia A. McNiff"'
Autor:
Yves A. Chantigny, Ralph P. Robinson, Kleinman Edward F, Jon Bordner, Patricia A. McNiff, Yuriy A. Abramov, John C. Murray, Michael A. Plotkin, Leonard Buckbinder, Michele L. Millham, Matthew R. Reese, Jean Schaefer
Publikováno v:
Journal of Medicinal Chemistry. 58:2658-2677
A significant improvement in agonist activity of the previously described 2-aryloctahydrophenanthrene-2,3,7-triol series of dissociated glucocorticoid receptor agonists (DAGRs) was achieved by modifying the substitution at C3 from (S)-3-hydroxy to (R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ca2438a1c9e112c199c73fa8c457da0
https://doi.org/10.1021/jm501601b
https://doi.org/10.1021/jm501601b
Autor:
Yuriy A. Abramov, John C. Murray, Leonard Buckbinder, Ellen R. Laird, Matthew R. Reese, Kleinman Edward F, Yves A. Chantigny, Matthew David Wessel, E. D. Salter, Sue A. Yocum, Morgan Bradley P, Ralph P. Robinson, Jean Schaefer, Amber I. Haugeto, Jon Bordner, Patricia A. McNiff, Michele L. Millham
Publikováno v:
Journal of Medicinal Chemistry. 52:1731-1743
As exemplified by the lead compound 2, octahydrophenanthrene-2,7-diol analogues exhibit the profile of a pathway-selective or "dissociated" agonist of the glucocorticoid receptor (GR), retaining the potent activity that glucocorticoids have for trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b7be2568bff2da7c37818c84b398c67
https://doi.org/10.1021/jm801512v
https://doi.org/10.1021/jm801512v
Autor:
Yasuhiro Kojima, Hiroyuki Nishida, Peter Binding, Yoshinobu Ueno, Val Lucas, Hiroko Kachi-Tonai, Takaaki Nakamura, Patricia A. McNiff, Christopher A. Gabel, Katsuomi Ichikawa, Nakao Kojima, Taisuke Inagaki
Publikováno v:
Biochemical and Biophysical Research Communications. 286:697-700
LL-Z1271α, a fungal metabolite, dose-dependently inhibited interleukin-1β (IL-1β) production in lipopolysaccharide (LPS)-stimulated human whole blood. Oral administration of LL-Z1271α to LPS-challenged mice caused significant lowering in the IL-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::307d5e99110cd6a73a7b5ac172bb1b4d
https://doi.org/10.1006/bbrc.2001.5458
https://doi.org/10.1006/bbrc.2001.5458
Publikováno v:
Biochemical Pharmacology. 50:1421-1432
Tenidap [5-chloro-2,3-dihydro-3-(hydroxy-2-thienylmethylene)-2-oxo-1H- indole-1-carboxamide], a novel antirheumatic agent, produces a rapid and sustained intracellular acidification when applied to cells in culture. To investigate the mechanism by wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08653290272fd91ec0005e4bd98e71d2
https://doi.org/10.1016/0006-2952(95)02034-9
https://doi.org/10.1016/0006-2952(95)02034-9
Autor:
Christopher J. Pazoles, Patricia A. McNiff, Linne Svensson, Christopher A. Gabel, Ronald E. Laliberte
Publikováno v:
Cytokine. 7:196-208
Tenidap is a novel anti-inflammatory and anti-arthritic agent that lowers intracellular pH and suppresses anion transport when applied to cells in vitro. Both of these parameters are known to influence pro-inflammatory cell function. To investigate w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d41eb4caf643a920037d380d2839a44
https://doi.org/10.1006/cyto.1995.1027
https://doi.org/10.1006/cyto.1995.1027
Publikováno v:
Journal of leukocyte biology. 62(2)
Despite a large production capacity, freshly isolated lipopolysaccharide (LPS)-activated human monocytes release only a small percentage of their newly synthesized interleukin (IL)-1β into the medium. Extracellular ATP, acting via surface P2z-type p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::098b0c02041bd6b5a8e391e925f0522e
https://pubmed.ncbi.nlm.nih.gov/9261337
https://pubmed.ncbi.nlm.nih.gov/9261337
Autor:
Caroline Stewart, Henry J. Showell, James F. Sullivan, Patricia A. McNiff, Christopher A. Gabel
Publikováno v:
Cytokine. 7(2)
The presence of positive acute phase proteins within the circulation of rheumatoid arthritis patients suggests that elevated cytokine production associated with this chronic inflammatory disorder initiates the hepatic acute phase response. Cytokines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::256b6456510a57178e80e1ee18472c49
https://pubmed.ncbi.nlm.nih.gov/7780041
https://pubmed.ncbi.nlm.nih.gov/7780041
Autor:
Ralph P. Robinson, Leonard Buckbinder, Amber I. Haugeto, Patricia A. McNiff, Michele L. Millham, Matthew R. Reese, Jean F. Schaefer, Yuriy A. Abramov, Jon Bordner, Yves A. Chantigny, Edward F. Kleinman, Ellen R. Laird, Bradley P. Morgan, John C. Murray, Eben D. Salter, Matthew D. Wessel, Sue A. Yocum
Publikováno v:
Journal of Medicinal Chemistry; Mar2009, Vol. 52 Issue 6, p1731-1743, 13p