Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Patricia A. Kruk"'
Autor:
Stephanie T. Buttermore, Mitchel S. Hoffman, Ambuj Kumar, Anne Champeaux, Santo V. Nicosia, Patricia A. Kruk
Publikováno v:
Journal of Ovarian Research, Vol 10, Iss 1, Pp 1-11 (2017)
Abstract Background Elevated hyaluronan-mediated motility receptor (RHAMM) has been reported to contribute to disease progression, aggressive phenotype and poor prognosis in multiple cancer types, however, RHAMM’s role in ovarian cancer (OC) has no
Externí odkaz:
https://doaj.org/article/7da4681ce9dd44a8bde497d434633290
Autor:
Kamisha T. Woolery, Patricia A. Kruk
Publikováno v:
Obstetrics and Gynecology International, Vol 2011 (2011)
Ovarian epithelial cancer is the most lethal gynecologic malignancy. The high mortality is attributed to the fact that most cases typically present in late stage when ovarian cancer (OC) has already spread beyond the ovary. Ovarian epithelial cancer
Externí odkaz:
https://doaj.org/article/4d13619e93584f1d917d08a1d4db818b
Publikováno v:
Obstetrics and Gynecology International, Vol 2009 (2009)
While semaphorins and their receptors appear to play a role in tumor carcinogenesis, little is known about the role of semaphorin 3F (S3F) in epithelial ovarian cancer (EOC) development. Therefore, we sought to determine the clinical relationship bet
Externí odkaz:
https://doaj.org/article/6872f9b4be74401eb123f362252caf61
Autor:
Santo V. Nicosia, Domenico Coppola, Nikhut Siddique, Wenlong Bai, Nicole N. Esposito, Mitchell Hoffman, Kimberly P. Dobrinski, Patricia A. Kruk, Robert M. Wenham, Xiaohong Zhang
Publikováno v:
Journal of the American Society of Cytopathology. 3:309-318
Introduction Fallopian tube intraepithelial cancer is a postulated precursor of epithelial ovarian carcinomas. As research continues on epithelial ovarian carcinomas' developmental pathways, representative tubal tissue must be procured for diagnostic
Autor:
Rebecca J. Linger, Patricia A. Kruk
Publikováno v:
FEBS Journal. 277:3086-3096
Mutations in the tumor suppressor breast cancer susceptibility gene 1 (BRCA1), an important player in the DNA damage response, apoptosis, cell cycle regulation and transcription, confer a significantly elevated lifetime risk for breast and ovarian ca
Autor:
Beatriz O. Saunders, Ren Chen, George D. Wilbanks, Santo V. Nicosia, Christina D. Drenberg, Patricia A. Kruk, Roberto F. Nicosia
Publikováno v:
Gynecologic Oncology. 117:117-124
Objective The poor prognosis associated with epithelial ovarian cancer (EOC) is due to the lack of overt early symptoms and the absence of reliable diagnostic screening methods. Since many tumors over express angiogenic regulators, the purpose of thi
Autor:
Robert C. Bast, Patricia A. Kruk, Donna Badgwell, Santo V. Nicosia, Nicole S. Anderson, Ren Chen, Yira Bermudez
Publikováno v:
Gynecologic Oncology. 112:60-67
The poor prognosis associated with ovarian cancer is due to the lack of overt early symptoms and the absence of reliable diagnostic screening methods. Since many tumors overexpress anti-apoptotic proteins, the purpose of this study was to determine w
Autor:
Patricia A. Kruk, Nancy Olashaw, S Yong, H Dong, Jiandong Chen, X Li, Wenlong Bai, Jin Q. Cheng, Xiaohong Zhang, Mu Zhang, Santo V. Nicosia, Yingtao Zhang
Publikováno v:
Oncogene. 28:445-460
Cortactin binds F-actin and promotes cell migration. We showed earlier that cortactin is acetylated. Here, we identify SIRT1 (a class III histone deacetylase) as a cortactin deacetylase and p300 as a cortactin acetylase. We show that SIRT1 deacetylat
Autor:
Santo V. Nicosia, Robert M. Wenham, Domenico Coppola, William Kong, Patricia A. Kruk, Jin Q. Cheng, Jian-jun Zhao, Hua Yang, Lili He, Joshua D. O'Donnell, Jia-Wang Wang
Publikováno v:
Cancer Research. 68:425-433
MicroRNAs (miRNA) represent a novel class of genes that function as negative regulators of gene expression. Recently, miRNAs have been implicated in several cancers. However, aberrant miRNA expression and its clinicopathologic significance in human o
Publikováno v:
Cancer Detection and Prevention. 31:119-128
Background : Dietary factors influence tumor formation and progression. Vitamin E is a dietary anti-oxidant capable of eliminating free radical damage, inducing apoptosis and decreasing oncogene expression. Therefore, Vitamin E may be a strong candid