Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Patricia A. Darrah"'
Autor:
Matthew S. Sutton, Allison N. Bucsan, Chelsea C. Lehman, Megha Kamath, Supriya Pokkali, Diogo M. Magnani, Robert Seder, Patricia A. Darrah, Mario Roederer
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Understanding the immunological control of pathogens requires a detailed evaluation of the mechanistic contributions of individual cell types within the immune system. While knockout mouse models that lack certain cell types have been used to help de
Externí odkaz:
https://doaj.org/article/95faee24c36f4d139c41cce54445ee40
Autor:
Elizabeth A. Thompson, Patricia A. Darrah, Kathryn E. Foulds, Elena Hoffer, Alayna Caffrey-Carr, Sophie Norenstedt, Leif Perbeck, Robert A. Seder, Ross M. Kedl, Karin Loré
Publikováno v:
Cell Reports, Vol 28, Iss 5, Pp 1127-1135.e4 (2019)
Summary: Using non-human primates (NHPs), mice, and human primary cells, we found a role for interleukin-10 (IL-10) in the upregulation of the tissue-resident memory T cell (TRM) marker CD103. In NHPs, intravenous, but not subcutaneous, immunization
Externí odkaz:
https://doaj.org/article/8414394f6b7d4b949f761c63d98542d3
Autor:
Patricia A. Darrah, Sally Shin, Robert A. Seder, Galit Alter, Deepak Kaushal, Smriti Mehra, Hannah P. Gideon, Anthony O’Neil, Abraham Pinter, JoAnne L. Flynn, Sarah M. Fortune, Mario Roederer, Edward B. Irvine, Wenjun Li, William J. Honnen, Alok Choudhary
Publikováno v:
Nature Immunology. 22:1515-1523
Development of an effective tuberculosis (TB) vaccine has suffered from an incomplete understanding of the correlates of protection against Mycobacterium tuberculosis (Mtb). Intravenous (i.v.) vaccination with Bacille Calmette–Guerin (BCG) provides
Autor:
Yiran E. Liu, Patricia A. Darrah, Joseph J. Zeppa, Megha Kamath, Farida Laboune, Daniel C. Douek, Pauline Maiello, Mario Roederer, JoAnne L. Flynn, Robert A. Seder, Purvesh Khatri
SUMMARYBlood-based correlates of vaccine-induced protection against tuberculosis (TB) are urgently needed. We analyzed the blood transcriptome of rhesus macaques immunized with varying doses of intravenous (IV) BCG followed byMycobacterium tuberculos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f0fb38c5ba51a76c26f5e13222bbfa9
https://doi.org/10.1101/2022.11.14.516343
https://doi.org/10.1101/2022.11.14.516343
Autor:
Robert A. Seder, John D. Altman, Soumik Barman, Mario Roederer, Patricia A. Darrah, Damien B. Wilburn, Adriaan J. Minnaard, Erik D. Layton, Krystle K. Q. Yu, Malisa T. Smith, Chetan Seshadri, Nabil Tahiri, Thomas J. Scriba
Publikováno v:
J Immunol
Journal of Immunology, 206(6), 1240-1250. AMER ASSOC IMMUNOLOGISTS
Journal of Immunology, 206(6), 1240-1250. AMER ASSOC IMMUNOLOGISTS
Intradermal vaccination with Mycobacterium bovis bacillus Calmette–Guérin (BCG) protects infants from disseminated tuberculosis, and i.v. BCG protects nonhuman primates (NHP) against pulmonary and extrapulmonary tuberculosis. In humans and NHP, pr
Autor:
Patricia A. Darrah, Joseph J. Zeppa, Chuangqi Wang, Edward B. Irvine, Allison N. Bucsan, Mark A. Rodgers, Supriya Pokkali, Joshua A. Hackney, Megha Kamath, Alexander G. White, H. Jacob Borish, L. James Frye, Jaime Tomko, Kara Kracinovsky, Philana L. Lin, Edwin Klein, Charles A. Scanga, Galit Alter, Sarah M. Fortune, Douglas A. Lauffenburger, JoAnne L. Flynn, Robert A. Seder, Pauline Maiello, Mario Roederer
Publikováno v:
SSRN Electronic Journal.
Autor:
JoAnne L. Flynn, Patricia A. Darrah, Phillip A. Swanson, Nicole L. Grant, Pauline Maiello, Chelsea M Causgrove, Travis K. Hughes, Danilo R. Casimiro, Megha Kamath, Joseph J. Zeppa, Edwin Klein, Supriya Pokkali, Alexander G. White, Mario Roederer, Philana Ling Lin, Joshua A Hackney, Aurelio Bonavia, Charles A. Scanga, Marc H. Wadsworth, Alex K. Shalek, Robert A. Seder, Dominick Laddy, Mark Rodgers
Publikováno v:
Nature. 577:95-102
Mycobacterium tuberculosis (Mtb) is the leading cause of death from infection worldwide1. The only available vaccine, BCG (Bacillus Calmette–Guerin), is given intradermally and has variable efficacy against pulmonary tuberculosis, the major cause o
Autor:
Anders Boyd, Jorge R Almeida, Patricia A Darrah, Delphine Sauce, Robert A Seder, Victor Appay, Guy Gorochov, Martin Larsen
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0128714 (2015)
Understanding the factors that delineate the efficacy of T cell responses towards pathogens is crucial for our ability to develop potent therapies against infectious diseases. Multidimensional evaluation of T cell functionality at the single-cell lev
Externí odkaz:
https://doaj.org/article/e2190b61888f45cc93d80c197fb0784d
Autor:
Anders Boyd, Jorge R Almeida, Patricia A Darrah, Delphine Sauce, Robert A Seder, Victor Appay, Guy Gorochov, Martin Larsen
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0138395 (2015)
Externí odkaz:
https://doaj.org/article/5e278a4e29c8412099971fba04e89fcb
Autor:
Deepak Kaushal, Robert A. Seder, Sally Shin, O’Neil A, Patricia A. Darrah, Wenjun Li, JoAnne L. Flynn, Sarah M. Fortune, Smriti Mehra, Hannah P. Gideon, Edward B. Irvine, Abraham Pinter, Mario Roederer, Alok Choudhary, William J. Honnen, Galit Alter
Development of an effective tuberculosis (TB) vaccine has suffered from an incomplete understanding of the correlates of protection against Mycobacterium tuberculosis (Mtb). However, recent work has shown that compared to standard intradermal Bacille
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e952b77ec45d5abde0fcba1079ac3a88
https://doi.org/10.1101/2021.05.06.442979
https://doi.org/10.1101/2021.05.06.442979