Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Patricia A. Culp"'
Publikováno v:
Biochemistry and Biophysics Reports, Vol 29, Iss , Pp 101205- (2022)
CRISPR/Cas9 gene-editing technology allows researchers to study protein function by specifically introducing double-stranded breaks in the gene of interest then analyze its subsequent loss in sensitive biological assays. To help characterize one of a
Externí odkaz:
https://doaj.org/article/df1a8ebe5ff44781a555a322c6d90a16
Autor:
Anand Panchal, Pui Seto, Russell Wall, Brian J. Hillier, Ying Zhu, Jessica Krakow, Aakash Datt, Elizabeth Pongo, Andisheh Bagheri, Tseng-Hui T. Chen, Jeremiah D. Degenhardt, Patricia A. Culp, Danielle E. Dettling, Maia V. Vinogradova, Chad May, Robert B. DuBridge
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
Conditionally active COBRA™ (COnditional Bispecific Redirected Activation) T cell engagers are engineered to overcome the limitations of inherently active first-generation T cell engagers, which are unable to discern between tumor and healthy tissu
Externí odkaz:
https://doaj.org/article/f2605ce7f19c42fe8f1f08cf99498254
Autor:
Shiming Ye, Melvin I. Fox, Nicole A. Belmar, Mien Sho, Debra T. Chao, Donghee Choi, Yuni Fang, Vivian Zhao, Stephen F. Keller, Gary C. Starling, Patricia A. Culp
Publikováno v:
Journal of Immunology Research, Vol 2017 (2017)
Enavatuzumab is a humanized IgG1 anti-TWEAK receptor monoclonal antibody that was evaluated in a phase I clinical study for the treatment of solid malignancies. The current study was to determine whether and how myeloid effector cells were involved i
Externí odkaz:
https://doaj.org/article/14443094aa82421d8333bf5917c19588
Autor:
James W. Purcell, Han K. Kim, Sonia G. Tanlimco, Minhtam eDoan, Melvin eFox, Peter eLambert, Debra T. Chao, Mien eSho, Keith E. Wilson, Gary C. Starling, Patricia A. Culp
Publikováno v:
Frontiers in Immunology, Vol 4 (2014)
TweakR is a TNF receptor family member, whose natural ligand is the multifunctional cytokine TWEAK. The growth inhibitory activity observed following TweakR stimulation in certain cancer cell lines and the overexpression of TweakR in many solid tumor
Externí odkaz:
https://doaj.org/article/2743f432050840d09fe948a8877e8326
Autor:
Robert Dubridge, Vanitha Ramakrishnan, David B. Powers, Debra T. Chao, Eric D. Hsi, Marjorie James, Marie Cardenas, Jennifer Grove, Ferdinand Evangelista, Melanie H.L. Wong, Roxanne Steinle, Mien Sho, Mian Su, Suzanne E. Ybarra, Pui Seto, Johnny Yin, Yongke Zhang, Donghee Choi, Patricia A. Culp
Supplementary Data from Antibodies to TWEAK Receptor Inhibit Human Tumor Growth through Dual Mechanisms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2604464c459cc7a933dbb26f10c6159f
https://doi.org/10.1158/1078-0432.22440232
https://doi.org/10.1158/1078-0432.22440232
Autor:
Robert Dubridge, Vanitha Ramakrishnan, David B. Powers, Debra T. Chao, Eric D. Hsi, Marjorie James, Marie Cardenas, Jennifer Grove, Ferdinand Evangelista, Melanie H.L. Wong, Roxanne Steinle, Mien Sho, Mian Su, Suzanne E. Ybarra, Pui Seto, Johnny Yin, Yongke Zhang, Donghee Choi, Patricia A. Culp
Purpose: Targeted therapeutics have significantly changed the outcome for patients diagnosed with cancer. Still, effective therapeutic intervention does not exist for many cancers and much remains to be done. The objective of this study was to identi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94c90a289cf91f77e4c3cc630c736c91
https://doi.org/10.1158/1078-0432.c.6517582
https://doi.org/10.1158/1078-0432.c.6517582
Autor:
Marion Richardson, Didier Decaudin, Sergio Roman-Roman, Aurélie Thuleau, Ivan Bièche, Véronique Diéras, Patricia A. Culp, C. Elbaz, Narjesse Karboul, Anne Vincent-Salomon, Sophie Vacher, Bernard Asselain, André Nicolas, Eléonore Gravier, Elisabetta Marangoni, Frédérique Berger, Ludmilla de Plater, Xavier Paoletti
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e104227 (2014)
PLoS ONE
PLoS ONE
Purpose(1) To determine TweakR expression in human breast cancers (BC), (2) evaluate the antitumor effect of the anti-TweakR antibody PDL192, used alone or after chemotherapy-induced complete remission (CR), on patient-derived BC xenografts (PDX) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aaf31249c8e2844f7e83616e4948061
https://doaj.org/article/8c0c43e5b4134d31b4cbe09a27a2de7f
https://doaj.org/article/8c0c43e5b4134d31b4cbe09a27a2de7f
Autor:
Nathalie A. Compagnone, Peilin Zhang, Jean-Louis Vigne, Thomas J. Musci, Synthia H. Mellon, Patricia A. Culp, Christelle Fiore
Publikováno v:
DNA and cell biology. 20(10)
Cytochrome P450c17 catalyzes the 17alpha-hydroxylase/17,20 lyase activity needed for sex steroid synthesis. We recently characterized the nuclear phosphoprotein SET as a novel transcriptional regulator that binds to the -447/-399 region of the rat P4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e790815f4388f935db3e09cfa157f2ee
https://pubmed.ncbi.nlm.nih.gov/11749720
https://pubmed.ncbi.nlm.nih.gov/11749720
Autor:
Patricia A. Culp, Thomas J. Musci
During oocyte maturation in Xenopus, previously quiescent maternal mRNAs are translationally activated at specific times. We hypothesized that the translational recruitment of individual messages is triggered by particular cellular events and investi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6266a6cd4574440a64260e4f0d623c8e
https://europepmc.org/articles/PMC25638/
https://europepmc.org/articles/PMC25638/
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 307:191-197
This study examined the effects of vanadate on the potassium dependent phosphatase activity present in purified human kidney microsomal (Na+ + K+)-adenosine triphosphatase. Vanadate anion inhibited the K+-dependent phosphatase at a K1 of 35 nM. This
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c6f3eb6e6ff61639ba846e8ce436155
https://doi.org/10.1007/bf00498463
https://doi.org/10.1007/bf00498463