Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Patricia A. Clinkenbeard"'
Autor:
Rebecca A. Duncan-Decocq, Patricia A. Clinkenbeard, Kimberly D. Hill, Nicole L. Clarkson, William W. Barrow, Michelle Wright Valderas, Kenneth D. Clinkenbeard, Christina R. Bourne, Esther W. Barrow, Rachel F. Perteet, Philip C. Bourne
Publikováno v:
SLAS Discovery. 17:946-956
One of the objectives of the National Institutes of Allergy and Infectious Diseases (NIAID) Biodefense Program is to identify or develop broad-spectrum antimicrobials for use against bioterrorism pathogens and emerging infectious agents. As a part of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c70d3da963dd9b527159d2992301037c
https://doi.org/10.1177/1087057112448216
https://doi.org/10.1177/1087057112448216
Autor:
Michael Shelton, George L. Murphy, Kenneth D. Clinkenbeard, Cyril R. Clarke, Laura Cudd, Patricia A. Clinkenbeard
Publikováno v:
FEMS Microbiology Letters. 172:123-129
Isolated neutrophils were used to study the intracellular calcium ([Ca2+]i) dependency of Pasteurella haemolytica leukotoxin-induced production of leukotriene B4 and plasma membrane damage. Exposure of neutrophils to leukotoxin caused a rapid and con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::085589493f28d99cc4f7d403129882e3
https://doi.org/10.1111/j.1574-6968.1999.tb13459.x
https://doi.org/10.1111/j.1574-6968.1999.tb13459.x
Publikováno v:
Veterinary Microbiology. 45:201-209
Pasteurella haemolytica biotype A, serotype 1 grown to late logarithmic growth phase in cell culture medium (RPMI 1640) produced highly aggregated leukotoxin. The multimer mass of the highly aggregated leukotoxin in 0.1 M sodium phosphate buffer pH 7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a69a81157a36dfaad75dd14a9da141fc
https://doi.org/10.1016/0378-1135(94)00131-f
https://doi.org/10.1016/0378-1135(94)00131-f
Publikováno v:
Infection and immunity. 67(12)
Pasteurella haemolytica , the causative agent of shipping fever pneumonia in cattle, produces a leukotoxin (LKT) which lyses ruminant leukocytes with high efficiency but is reputed to not affect leukocytes from nonruminant species. In this study, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::888661f9a0b147e5f9bc1ce6fab8b9ef
https://pubmed.ncbi.nlm.nih.gov/10569736
https://pubmed.ncbi.nlm.nih.gov/10569736
Publikováno v:
Infection and immunity. 63(8)
A Pasteurella haemolytica mutant incapable of producing leukotoxin was created by allelic replacement. Concentrated culture supernatants from wild-type P. haemolytica, but not from the mutant, contained the 102-kDa leukotoxin protein and lysed bovine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a6b8aa8f5cff6134328e2505fe8e7bf
https://pubmed.ncbi.nlm.nih.gov/7622250
https://pubmed.ncbi.nlm.nih.gov/7622250