Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Patricia A. Champion"'
Autor:
Bradley S. Jones, Daniel D. Hu, Kathleen R. Nicholson, Rachel M. Cronin, Simon D. Weaver, Matthew M. Champion, Patricia A. Champion
Publikováno v:
mSphere, Vol 9, Iss 5 (2024)
ABSTRACT The mycobacterial cell envelope is a major virulence determinant in pathogenic mycobacteria. Specific outer lipids play roles in pathogenesis, modulating the immune system and promoting the secretion of virulence factors. ESX-1 (ESAT-6 syste
Externí odkaz:
https://doaj.org/article/63c1e0bddc6843a287d8a6f4cb68bdb7
Autor:
Kathleen R. Nicholson, Rachel M. Cronin, Rebecca J. Prest, Aruna R. Menon, Yuwei Yang, Madeleine K. Jennisch, Matthew M. Champion, David M. Tobin, Patricia A. Champion
Publikováno v:
mBio, Vol 15, Iss 4 (2024)
ABSTRACTBacterial pathogens use protein secretion systems to transport virulence factors and regulate gene expression. Among pathogenic mycobacteria, including Mycobacterium tuberculosis and Mycobacterium marinum, the ESAT-6 system 1 (ESX-1) secretio
Externí odkaz:
https://doaj.org/article/98c5e246555a43a18ff67290f38d2e86
Autor:
Owen A. Collars, Bradley S. Jones, Daniel D. Hu, Simon D. Weaver, Taylor A. Sherman, Matthew M. Champion, Patricia A. Champion
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT N-terminal protein acetylation is a ubiquitous post-translational modification that impacts diverse cellular processes in higher organisms. Bacterial proteins are also N-terminally acetylated, but the mechanisms and consequences of this modi
Externí odkaz:
https://doaj.org/article/3da7bd96f9d04bb2a861ece31401ffc4
Autor:
Kevin G. Sanchez, Micah J. Ferrell, Alexandra E. Chirakos, Kathleen R. Nicholson, Robert B. Abramovitch, Matthew M. Champion, Patricia A. Champion
Publikováno v:
mBio, Vol 11, Iss 1 (2020)
ABSTRACT Pathogenic mycobacteria encounter multiple environments during macrophage infection. Temporally, the bacteria are engulfed into the phagosome, lyse the phagosomal membrane, and interact with the cytosol before spreading to another cell. Viru
Externí odkaz:
https://doaj.org/article/bf0cf4ea555448b694cb750f870159e3
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 9 (2019)
Externí odkaz:
https://doaj.org/article/1fb773be8a184bff9eebc6d505faf966
Autor:
Owen A. Collars, Bradley S Jones, Daniel D Hu, Simon D Weaver, Matthew M Champion, Patricia A. Champion
Publikováno v:
bioRxiv
N-terminal protein acetylation is a ubiquitous post-translational modification that broadly impacts diverse cellular processes in higher organisms. Bacterial proteins are also N-terminally acetylated, but the mechanisms and consequences of this modif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d36f5a3588e2e33247c676064ce76366
https://doi.org/10.1101/2023.03.14.532585
https://doi.org/10.1101/2023.03.14.532585
Autor:
Kathleen R. Nicholson, Rachel M. Cronin, Aruna R. Menon, Madeleine K. Jennisch, David M. Tobin, Patricia A. Champion
Publikováno v:
bioRxiv
Bacterial pathogens use protein secretion systems to translocate virulence factors into the host and to control bacterial gene expression. The ESX-1 (ESAT-6 system 1) secretion system facilitates disruption of the macrophage phagosome during infectio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0be6350a29983cb99cce050ce4e1bc5
https://doi.org/10.1101/2023.02.15.528779
https://doi.org/10.1101/2023.02.15.528779
Autor:
Kevin G. Sanchez, Rebecca J. Prest, Kathleen R. Nicholson, Konstantin V. Korotkov, Patricia A. Champion
Publikováno v:
J Bacteriol
Pathogenic mycobacteria use the ESX-1 secretion system to escape the macrophage phagosome and survive infection. We demonstrated that the ESX-1 system is regulated by feedback control in Mycobacterium marinum, a nontuberculous pathogen and model for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97eb16559dd90b2d3cb7dd8abaeb7f68
https://europepmc.org/articles/PMC9765225/
https://europepmc.org/articles/PMC9765225/
Autor:
Joseph W. Saelens, Mollie I. Sweeney, Gopinath Viswanathan, Ana María Xet-Mull, Kristen L. Jurcic Smith, Dana M. Sisk, Daniel D. Hu, Rachel M. Cronin, Erika J. Hughes, W. Jared Brewer, Jörn Coers, Matthew M. Champion, Patricia A. Champion, Craig B. Lowe, Clare M. Smith, Sunhee Lee, Jason E. Stout, David M. Tobin
Publikováno v:
Cell
The human pathogen Mycobacterium tuberculosis typically causes lung disease but can also disseminate to other tissues. We identified a M. tuberculosis (Mtb) outbreak presenting with unusually high rates of extrapulmonary dissemination and bone diseas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83917a2f0a20514c1f17e7753d9b41f9
https://europepmc.org/articles/PMC9691622/
https://europepmc.org/articles/PMC9691622/
Autor:
Rachel M, Cronin, Micah J, Ferrell, Clare W, Cahir, Matthew M, Champion, Patricia A, Champion
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(24)
The ESX-1 (ESAT-6-system-1) system and the protein substrates it transports are essential for mycobacterial pathogenesis. The precise ways that ESX-1 substrates contribute to virulence remains unknown. Several known ESX-1 substrates are also required