Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Patricia A. Champion"'
Autor:
Bradley S. Jones, Daniel D. Hu, Kathleen R. Nicholson, Rachel M. Cronin, Simon D. Weaver, Matthew M. Champion, Patricia A. Champion
Publikováno v:
mSphere, Vol 9, Iss 5 (2024)
ABSTRACT The mycobacterial cell envelope is a major virulence determinant in pathogenic mycobacteria. Specific outer lipids play roles in pathogenesis, modulating the immune system and promoting the secretion of virulence factors. ESX-1 (ESAT-6 syste
Externí odkaz:
https://doaj.org/article/63c1e0bddc6843a287d8a6f4cb68bdb7
Autor:
Kathleen R. Nicholson, Rachel M. Cronin, Rebecca J. Prest, Aruna R. Menon, Yuwei Yang, Madeleine K. Jennisch, Matthew M. Champion, David M. Tobin, Patricia A. Champion
Publikováno v:
mBio, Vol 15, Iss 4 (2024)
ABSTRACTBacterial pathogens use protein secretion systems to transport virulence factors and regulate gene expression. Among pathogenic mycobacteria, including Mycobacterium tuberculosis and Mycobacterium marinum, the ESAT-6 system 1 (ESX-1) secretio
Externí odkaz:
https://doaj.org/article/98c5e246555a43a18ff67290f38d2e86
Publikováno v:
PLoS ONE, Vol 19, Iss 2, p e0281564 (2024)
Retinoic acid inducible gene I (Rig-I) is a cytosolic pattern recognition receptor canonically described for its important role in sensing viral RNAs. Increasingly, bacterially-derived RNA from intracellular bacteria such as Mycobacterium tuberculosi
Externí odkaz:
https://doaj.org/article/c1d64d00e4c3423082f00305ec4efeb9
Autor:
Owen A. Collars, Bradley S. Jones, Daniel D. Hu, Simon D. Weaver, Taylor A. Sherman, Matthew M. Champion, Patricia A. Champion
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT N-terminal protein acetylation is a ubiquitous post-translational modification that impacts diverse cellular processes in higher organisms. Bacterial proteins are also N-terminally acetylated, but the mechanisms and consequences of this modi
Externí odkaz:
https://doaj.org/article/3da7bd96f9d04bb2a861ece31401ffc4
Publikováno v:
PLoS Pathogens, Vol 18, Iss 7, p e1010610 (2022)
Externí odkaz:
https://doaj.org/article/598ab8a4b14a4bfcb58390f58970140b
Publikováno v:
PLoS Pathogens, Vol 17, Iss 1, p e1009124 (2021)
Mycobacterial pathogens pose a sustained threat to human health. There is a critical need for new diagnostics, therapeutics, and vaccines targeting both tuberculous and nontuberculous mycobacterial species. Understanding the basic mechanisms used by
Externí odkaz:
https://doaj.org/article/cb022204bac0483da6f50be590b30e82
Autor:
Kevin G. Sanchez, Micah J. Ferrell, Alexandra E. Chirakos, Kathleen R. Nicholson, Robert B. Abramovitch, Matthew M. Champion, Patricia A. Champion
Publikováno v:
mBio, Vol 11, Iss 1 (2020)
ABSTRACT Pathogenic mycobacteria encounter multiple environments during macrophage infection. Temporally, the bacteria are engulfed into the phagosome, lyse the phagosomal membrane, and interact with the cytosol before spreading to another cell. Viru
Externí odkaz:
https://doaj.org/article/bf0cf4ea555448b694cb750f870159e3
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 9 (2019)
Externí odkaz:
https://doaj.org/article/1fb773be8a184bff9eebc6d505faf966
Autor:
Owen A. Collars, Bradley S Jones, Daniel D Hu, Simon D Weaver, Matthew M Champion, Patricia A. Champion
Publikováno v:
bioRxiv
N-terminal protein acetylation is a ubiquitous post-translational modification that broadly impacts diverse cellular processes in higher organisms. Bacterial proteins are also N-terminally acetylated, but the mechanisms and consequences of this modif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d36f5a3588e2e33247c676064ce76366
https://doi.org/10.1101/2023.03.14.532585
https://doi.org/10.1101/2023.03.14.532585
Autor:
Kathleen R. Nicholson, Rachel M. Cronin, Aruna R. Menon, Madeleine K. Jennisch, David M. Tobin, Patricia A. Champion
Publikováno v:
bioRxiv
Bacterial pathogens use protein secretion systems to translocate virulence factors into the host and to control bacterial gene expression. The ESX-1 (ESAT-6 system 1) secretion system facilitates disruption of the macrophage phagosome during infectio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0be6350a29983cb99cce050ce4e1bc5
https://doi.org/10.1101/2023.02.15.528779
https://doi.org/10.1101/2023.02.15.528779