Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Patricia A. Blundell"'
Publikováno v:
The Journal of Immunology Author Choice
Key Points Choice of cell line is critical for functional glycosylation of human IgG1-Fc. Sialylated IgG1-Fc monomers block influenza B only when made by CHO-K1 cells.
Abs are glycoproteins that carry a conserved N-linked carbohydrate attached t
Abs are glycoproteins that carry a conserved N-linked carbohydrate attached t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff14ea7adc6a9bcc25603c5b4553f9a2
http://europepmc.org/articles/PMC6994840
http://europepmc.org/articles/PMC6994840
Antibodies are glycoproteins that carry a conserved N-linked carbohydrate attached to the Fc, whose presence and fine structure profoundly impacts on their in vivo immunogenicity, pharmacokinetics and functional attributes. The host cell line used to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36b33943c131a3f059a3a37bfe56593f
Publikováno v:
Methods in Molecular Biology ISBN: 9781493989577
Engineering the fragment crystallizable (Fc) of human IgG can bring improved effector functions to monoclonal antibodies and Fc-fusion-based medicines and vaccines. Such Fc-effector functions are largely controlled by posttranslational modifications
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63fdd99dc5936de6cc6be3a78894f651
https://doi.org/10.1007/978-1-4939-8958-4_20
https://doi.org/10.1007/978-1-4939-8958-4_20
Autor:
Patricia A, Blundell, Dongli, Lu, Mark, Wilkinson, Anne, Dell, Stuart, Haslam, Richard J, Pleass
Publikováno v:
The Journal of Immunology Author Choice
In therapeutic applications in which the Fc of IgG is critically important, the receptor binding and functional properties of the Fc are lost after deglycosylation or removal of the unique Asn297 N-X-(T/S) sequon. A population of Fcs bearing sialylat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0a12e709ce32f8b91701fe722372d7a1
https://pubmed.ncbi.nlm.nih.gov/30683699
https://pubmed.ncbi.nlm.nih.gov/30683699
Autor:
Patricia A, Blundell, Ngoc Phuong Lan, Le, Joel, Allen, Yasunori, Watanabe, Richard J, Pleass
Publikováno v:
The Journal of Biological Chemistry
Multimeric fragment crystallizable (Fc) regions and Fc-fusion proteins are actively being explored as biomimetic replacements for IVIG therapy, which is deployed to manage many diseases and conditions but is expensive and not always efficient. The Fc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::21a0683b9cca29c651732b61fbc3edf1
https://pubmed.ncbi.nlm.nih.gov/28620050
https://pubmed.ncbi.nlm.nih.gov/28620050
Autor:
Zhifeng Shao, Gang Wu, Daniel M. Czajkowsky, David N. A. Mekhaiel, Shona C Moore, Stuart M. Haslam, Richard J. Pleass, Marco Colonna, Jianfeng He, Inger Sandlie, Anja Fuchs, Patricia A. Blundell, Anne Dell, Daniel A. Mitchell, Tim Wilson, Katy A. Lloyd, Jan Terje Andersen
Publikováno v:
Scientific Reports
The remarkable clinical success of Fc-fusion proteins has driven intense investigation for even more potent replacements. Using quality-by-design (QbD) approaches, we generated hexameric-Fc (hexa-Fc), a ~20 nm oligomeric Fc-based scaffold that we her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f06e24677e5bbb787291379379c0537a
http://europepmc.org/articles/PMC5224519
http://europepmc.org/articles/PMC5224519
Autor:
Patricia A Blundell, Piet Borst
Publikováno v:
Molecular and Biochemical Parasitology. 94:67-85
Trypanosoma brucei survives in the mammalian bloodstream by antigenic variation of its variant surface glycoprotein (VSG) coat. VSG genes are found in telomeric expression sites (ESs), and only one ES is fully transcribed at a time. The parasite chan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f0583d9d2913216e4f5e21f39a4db62
https://doi.org/10.1016/s0166-6851(98)00051-6
https://doi.org/10.1016/s0166-6851(98)00051-6
Publikováno v:
Molecular and Biochemical Parasitology. 76:215-229
Integration of exogenous DNA into the trypanosome genome occurs by homologous recombination only. To test whether a high degree of homology between donor and target DNA is required, we have inserted marker genes for drug resistance into the promoter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c7f9fd91a4003c9dea9f0133b609007
https://doi.org/10.1016/0166-6851(95)02560-x
https://doi.org/10.1016/0166-6851(95)02560-x
Publikováno v:
Cell. 83(4):547-553
Trypanosoma brucei survives in the mammalian blood-stream by regularly changing its variant surface glycoprotein (VSG) coat. The active VSG gene is located in a telomeric expression site, and coat switching occurs either by replacing the transcribed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36bdb5bef83bb3ac612cce29130e6a38
Autor:
Michael L. Ginger, J. David Barry, Arthur Günzl, Alison Browitt, A. M. Lewis, Patricia A. Blundell
Publikováno v:
Eukaryotic cell. 1(6)
The trypanosome variant surface glycoprotein (VSG) is first expressed during differentiation to the infective, metacyclic population in tsetse fly salivary glands. Unlike the VSG genes expressed by bloodstream form trypanosomes, metacyclic VSG s ( MV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97ff42223cf3d9020aaeb37285f14c3e
https://pubmed.ncbi.nlm.nih.gov/12477800
https://pubmed.ncbi.nlm.nih.gov/12477800