Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Patricia A. Blair"'
Autor:
Patricia M. Blair, Miriam L. Land, Marek J. Piatek, Daniel A. Jacobson, Tse-Yuan S. Lu, Mitchel J. Doktycz, Dale A. Pelletier
Publikováno v:
mSystems, Vol 3, Iss 5 (2018)
ABSTRACT Natural products (NPs) isolated from bacteria have dramatically advanced human society, especially in medicine and agriculture. The rapidity and ease of genome sequencing have enabled bioinformatics-guided NP discovery and characterization.
Externí odkaz:
https://doaj.org/article/67bbb1c720a04215bad3562ce5c97b57
Autor:
Douglas A. Mitchell, Patricia M. Blair, Caitlin D. Deane, Alice Lin, Jonathan I. Tietz, Brandon J. Burkhart
Publikováno v:
ACS Chemical Biology. 11:2232-2243
Plantazolicin (PZN) is a ribosomally synthesized and post-translationally modified peptide (RiPP) natural product that exhibits extraordinarily narrow-spectrum antibacterial activity toward the causative agent of anthrax, Bacillus anthracis. During P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41bf83be40cdd44d12573870542d0803
https://doi.org/10.1021/acschembio.6b00369
https://doi.org/10.1021/acschembio.6b00369
Autor:
Jeremy R. Hershfield, Seongjin Park, Tucker Maxson, Taekjip Ha, Nathan E. Schroeder, Kristen M. Flatt, Douglas A. Mitchell, Katie J. Molohon, Patricia M. Blair, James R. Doroghazi
Publikováno v:
ACS Infectious Diseases. 2:207-220
Plantazolicin (PZN) is a ribosomally synthesized and post-translationally modified natural product from Bacillus methylotrophicus FZB42 and Bacillus pumilus. Extensive tailoring to twelve of the fourteen amino acid residues in the mature natural prod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d728a5922f7402ce54ad066166a5d448
https://doi.org/10.1021/acsinfecdis.5b00115
https://doi.org/10.1021/acsinfecdis.5b00115
Publikováno v:
Organic Letters. 15:5076-5079
A convergent strategy for the synthesis of truncated analogues of plantazolicin (PZN), a member of the thiazole/oxazole-modified microcin (TOMM) class of natural products, has been developed. These N-terminal mono-, tri-, and pentazole substructures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e25735760876d7c1d68aff46082fbd3
https://doi.org/10.1021/ol402444a
https://doi.org/10.1021/ol402444a
Autor:
Patricia L. Blair
Publikováno v:
Journal of Emergency Nursing. 39:e75-e78
Lateral violence in the nursing workplace can be defined as horizontal violence, bullying, and workplace incivility. 1 As with many problems, part of the solution may be the very recognition of it. Kirchner 1 found that 1 in 6 employees in the health
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d160f14a54c4daf32b6ba8b1c448d753
https://doi.org/10.1016/j.jen.2011.12.006
https://doi.org/10.1016/j.jen.2011.12.006
Autor:
Yue Hao, Brandon J. Burkhart, Douglas A. Mitchell, Joel O. Melby, Patricia M. Blair, Vinayak Agarwal, Satish K. Nair, Jaeheon Lee
Publikováno v:
Proceedings of the National Academy of Sciences. 110:12954-12959
Plantazolicin (PZN), a polyheterocyclic, N α ,N α -dimethylarginine–containing antibiotic, harbors remarkably specific bactericidal activity toward strains of Bacillus anthracis , the causative agent of anthrax. Previous studies demonstrated that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44a5ff4a372e521632589217325f718b
https://doi.org/10.1073/pnas.1306101110
https://doi.org/10.1073/pnas.1306101110
Publikováno v:
Bioorganicmedicinal chemistry. 24(24)
The hygrolides, a family of 16-member-ring-containing plecomacrolides produced by Actinobacteria, exhibit numerous reported bioactivities. Using HR-MS/MS, nucleophilic 1,4-addition-based labeling, NMR, and bioinformatic analysis, we identified Strept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3acd8d34c81691f0a829c06f3dfadbb0
https://pubmed.ncbi.nlm.nih.gov/27234886
https://pubmed.ncbi.nlm.nih.gov/27234886
Publikováno v:
ACS chemical biology. 10(5)
Peptide antibiotics represent a class of conformationally constrained natural products of growing pharmaceutical interest. Plantazolicin (PZN) is a linear, polyheterocyclic natural product with highly selective and potent activity against the anthrax
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8403ae87c8d200c0e1a50c722df57fb8
https://pubmed.ncbi.nlm.nih.gov/25635336
https://pubmed.ncbi.nlm.nih.gov/25635336
Publikováno v:
Journal of General Internal Medicine. 8:199-203
Objective: To determine whether the protective effects of seat belt use on acute injury are followed by corresponding reductions in outpatient health care utilization. Design: Retrospective cohort analysis. Setting: Northern California Region Kaiser
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff05e0c9326fbaab8ee38c0c09e5ea5a
https://doi.org/10.1007/bf02599267
https://doi.org/10.1007/bf02599267
Publikováno v:
Toxicology and Applied Pharmacology. 106:341-345
Earlier reports from this laboratory indicated that 2-butoxyethanol (BE) causes acute hemolytic anemia in rats as evidenced by a time- and dose-dependent decrease in the number of red blood cells, in hemoglobin concentrations, and in hematocrits (HCT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c69da09db49f6d7522a1a918160c0939
https://doi.org/10.1016/0041-008x(90)90253-q
https://doi.org/10.1016/0041-008x(90)90253-q