Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Patricia A. Trimmer"'
Autor:
Emily N. Cronin-Furman, Jennifer Barber-Singh, Kristen E. Bergquist, Takao Yagi, Patricia A. Trimmer
Publikováno v:
Biomolecules, Vol 9, Iss 4, p 119 (2019)
Parkinson’s disease (PD) is a neurodegenerative disorder that exhibits aberrant protein aggregation and mitochondrial dysfunction. Ndi1, the yeast mitochondrial NADH dehydrogenase (complex I) enzyme, is a single subunit, internal matrix-facing prot
Externí odkaz:
https://doaj.org/article/dff8c86f4e774f288a4c74261319d47a
Autor:
Patricia A. Trimmer, Paula M. Keeney, M.Kate Borland, Frederic A. Simon, Jatanna Almeida, Russell H. Swerdlow, Janice P. Parks, W.Davis Parker, Jr., James P. Bennett, Jr.
Publikováno v:
Neurobiology of Disease, Vol 15, Iss 1, Pp 29-39 (2004)
We created and studied new cybrid cell lines from sporadic Alzheimer's disease (SAD) or control (CTL) subjects to assess mitochondrial abnormalities just after metabolic selection (“early passage”) and again six passages later (“late passage”
Externí odkaz:
https://doaj.org/article/d51c8a53b34e40b289bba1b586bc0bad
Publikováno v:
Experimental neurology. 283
Axonal injury is present in essentially all clinically significant cases of traumatic brain injury (TBI). While no effective treatment has been identified to date, experimental TBI models have shown promising axonal protection using immunosuppressant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5479ce8b3c071ad08dd30154fb656095
https://pubmed.ncbi.nlm.nih.gov/27302680
https://pubmed.ncbi.nlm.nih.gov/27302680
Autor:
Kristen E. Bergquist, Kathleen M. Schwarz, Patricia A. Trimmer, Shilpa Iyer, Ravindar R. Thomas, Christina M. Papageorge, James P. Bennett, Shaharyar M. Khan, Lisa D. Dunham, Caitlin K. Quigley, Paula M. Keeney, Francisco R. Portell
Publikováno v:
Human Gene Therapy. 20:897-907
Neurodegeneration in Parkinson's disease (PD) affects mainly dopaminergic neurons in the substantia nigra, where age-related, increasing percentages of cells lose detectable respiratory activity associated with depletion of intact mitochondrial DNA (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::550675f8d4111707ff0569aa964c0aa6
https://doi.org/10.1089/hum.2009.023
https://doi.org/10.1089/hum.2009.023
Publikováno v:
Journal of Neurochemistry. 97:724-736
Cortical nitric oxide (NO) production increases during hypoxia/ischemia in the immature brain and is associated with both neurotoxicity and mitochondrial dysfunction. Mitochondrial redistribution within the cell is critical to normal neuronal functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55f3d8a9dd68956320f6489db44db1ba
https://doi.org/10.1111/j.1471-4159.2006.03767.x
https://doi.org/10.1111/j.1471-4159.2006.03767.x
Autor:
W. Davis Parker, Janice P. Parks, M.Kate Borland, Jatanna Almeida, Russell H. Swerdlow, Patricia A. Trimmer, Frederic A. Simon, Paula M. Keeney, James P. Bennett
Publikováno v:
Neurobiology of Disease, Vol 15, Iss 1, Pp 29-39 (2004)
We created and studied new cybrid cell lines from sporadic Alzheimer's disease (SAD) or control (CTL) subjects to assess mitochondrial abnormalities just after metabolic selection ("early passage") and again six passages later ("late passage"). Cytoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ef57d61a1e73ecd8fd2e9e529593d29
http://www.sciencedirect.com/science/article/pii/S096999610300192X
http://www.sciencedirect.com/science/article/pii/S096999610300192X
Publikováno v:
Journal of Neurochemistry. 88:800-812
Many models of Parkinson's disease (PD) have succeeded in replicating dopaminergic neuron loss or α-synuclein aggregation but not the formation of classical Lewy bodies, the pathological hallmark of PD. Our cybrid model of sporadic PD was created by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::550ee0103f16570c0db61894d5f651ed
https://doi.org/10.1046/j.1471-4159.2003.02168.x
https://doi.org/10.1046/j.1471-4159.2003.02168.x
Publikováno v:
Journal of Neurochemistry. 67:1897-1907
Mitochondrial dysfunction and attendant bioenergetic defects are increasingly recognized as playing an important role in neurodegenerative disorders. The increased attention on mitochondrial involvement points to the need for developing cell lines th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8091e41e7714f694f0725cef0257e03d
https://doi.org/10.1046/j.1471-4159.1996.67051897.x
https://doi.org/10.1046/j.1471-4159.1996.67051897.x
Autor:
Nina J, Solenski, Charles G, diPierro, Patricia A, Trimmer, Aij-Li, Kwan, Gregory A, Helm, Gregory A, Helms
Publikováno v:
Stroke. 33:816-824
Background and Purpose — Mitochondrial swelling is one of the most striking and initial ultrastructural changes after acute brain ischemia. The purpose of the present study was to examine the role of reperfusion of the cerebral cortex after transie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::159993aa856358ce007b4d8e379c0adb
https://doi.org/10.1161/hs0302.104541
https://doi.org/10.1161/hs0302.104541
Publikováno v:
Journal of Neurochemistry. 76:1050-1056
Beta amyloid (Abeta) peptides accumulate in Alzheimer's disease and are neurotoxic possibly through the production of oxygen free radicals. Using brain microdialysis we characterized the ability of Abeta to increase oxygen radical production in vivo.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66dfa9b0462d76d161eb353e6ee21ccb
https://doi.org/10.1046/j.1471-4159.2001.00112.x
https://doi.org/10.1046/j.1471-4159.2001.00112.x