Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Patricia A Vignaux"'
Publikováno v:
PLoS ONE, Vol 14, Iss 7, p e0217699 (2019)
Durable gene silencing through the formation of compact heterochromatin domains plays a critical role during mammalian development in establishing defined tissues capable of retaining cellular identity. Hallmarks of heterochromatin gene repression ar
Externí odkaz:
https://doaj.org/article/bc19ce24ee1e468aac77467cc89694f1
Autor:
Scott H. Snyder, Patricia A. Vignaux, Mustafa Kemal Ozalp, Jacob Gerlach, Ana C. Puhl, Thomas R. Lane, John Corbett, Fabio Urbina, Sean Ekins
Publikováno v:
Communications Chemistry, Vol 7, Iss 1, Pp 1-11 (2024)
Abstract Recent advances in machine learning (ML) have led to newer model architectures including transformers (large language models, LLMs) showing state of the art results in text generation and image analysis as well as few-shot learning (FSLC) mo
Externí odkaz:
https://doaj.org/article/35dfdbecd04240859dca01d619069e05
Autor:
Patricia A. Vignaux, Thomas R. Lane, Ana C. Puhl, Raymond K. Hau, Stephen H. Wright, Nathan J. Cherrington, Sean Ekins
Publikováno v:
ACS Omega. 8:12532-12537
Autor:
Patricia A. Vignaux, Thomas R. Lane, Fabio Urbina, Jacob Gerlach, Ana C. Puhl, Scott H. Snyder, Sean Ekins
Publikováno v:
Chemical Research in Toxicology. 36:188-201
Autor:
Matthew B. Neiditch, Patricia A Vignaux, Kimberley M. Zorn, Thomas J. Lane, Sean Ekins, Ana C. Puhl, Joel S. Freundlich, Glenn C. Capodagli
Publikováno v:
ACS Omega, Vol 5, Iss 46, Pp 29935-29942 (2020)
Tuberculosis is caused by Mycobacterium tuberculosis (Mtb) and is a deadly disease resulting in the deaths of approximately 1.5 million people with 10 million infections reported in 2018. Recently, a key condensation step in the synthesis of mycolic
Publikováno v:
ACS Omega, Vol 5, Iss 41, Pp 26551-26561 (2020)
ACS Omega
ACS Omega
Alzheimer’s disease (AD) is the most common cause of dementia, affecting approximately 35 million people worldwide. The current treatment options for people with AD consist of drugs designed to slow the rate of decline in memory and cognition, but
Autor:
Peter B. Madrid, Daniel H. Foil, Sean Ekins, Ana C. Puhl, Thomas J. Lane, Patricia A Vignaux, Eni Minerali
Publikováno v:
Chem Res Toxicol
Acetylcholinesterase (AChE) is an important drug target in neurological disorders like Alzheimer’s Disease, Lewy Body dementia and Parkinson’s Disease dementia, as well as for other conditions like myasthenia gravis and anticholinergic poisoning.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5af03e6ccd87775128757ad3951ebbe0
https://europepmc.org/articles/PMC8215598/
https://europepmc.org/articles/PMC8215598/
Autor:
Ana C, Puhl, Thomas R, Lane, Patricia A, Vignaux, Kimberley M, Zorn, Glenn C, Capodagli, Matthew B, Neiditch, Joel S, Freundlich, Sean, Ekins
Publikováno v:
ACS Omega
Tuberculosis is caused by Mycobacterium tuberculosis (Mtb) and is a deadly disease resulting in the deaths of approximately 1.5 million people with 10 million infections reported in 2018. Recently, a key condensation step in the synthesis of mycolic
Autor:
Eni Minerali, Anthony J. Hickey, Patricia A Vignaux, Jennifer J. Klein, Tammy M. Havener, Edward Anderson, Ana C. Puhl, Sean Ekins
Publikováno v:
Molecular Genetics and Metabolism. 132:S88-S89
Autor:
Patricia A Vignaux, Daniel H. Foil, Jennifer J. Klein, Ana C. Puhl, Sean Ekins, Kimberley M. Zorn
Publikováno v:
Molecular Genetics and Metabolism. 129:S132