Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Patricia A Thibault"'
Autor:
Satoshi Ikegame, Shannon M Beaty, Christian Stevens, Taylor Won, Arnold Park, David Sachs, Patrick Hong, Benhur Lee, Patricia A Thibault
Publikováno v:
PLoS Pathogens, Vol 16, Iss 10, p e1008877 (2020)
The antigenic and genomic stability of paramyxoviruses remains a mystery. Here, we evaluate the genetic plasticity of Sendai virus (SeV) and mumps virus (MuV), sialic acid-using paramyxoviruses that infect mammals from two Paramyxoviridae subfamilies
Externí odkaz:
https://doaj.org/article/c4fa34d2d8c24fb08f8972c939d22f10
Autor:
Arnold Park, Patrick Hong, Sohui T Won, Patricia A Thibault, Frederic Vigant, Kasopefoluwa Y Oguntuyo, Justin D Taft, Benhur Lee
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)
The advent of RNA-guided endonuclease (RGEN)-mediated gene editing, specifically via CRISPR/Cas9, has spurred intensive efforts to improve the efficiency of both RGEN delivery and targeted mutagenesis. The major viral vectors in use for delivery of C
Externí odkaz:
https://doaj.org/article/a47e9ef0babb4529a61546002c818f9a
Autor:
Hannah E. Salapa, Patricia A. Thibault, Cole D. Libner, Yulian Ding, Joseph-Patrick W. E. Clarke, Connor Denomy, Catherine Hutchinson, Hashim M. Abidullah, S. Austin Hammond, Landon Pastushok, Frederick S. Vizeacoumar, Michael C. Levin
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Neurodegeneration is the primary driver of disease progression in multiple sclerosis (MS) resulting in permanent disability, creating an urgent need to discover its underlying mechanisms. Herein, we establish that dysfunction of the RNA bind
Externí odkaz:
https://doaj.org/article/3e648027a8214c6e949a7e6dd685c808
Autor:
Patricia A Thibault, Joyce A Wilson
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89971 (2014)
Hepatitis C Virus (HCV) is a serious global health problem, infecting almost 3% of the world's population. The lack of model systems for studying this virus limit research options in vaccine and therapeutic development, as well as for studying the pa
Externí odkaz:
https://doaj.org/article/6cf1e1a911b34d79bf24ae09404de79a
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e67437 (2013)
DDX6 and other P-body proteins are required for efficient replication of Hepatitis C Virus (HCV) by unknown mechanisms. DDX6 has been implicated in miRNA induced gene silencing, and since efficient HCV replication and translation relies on the cellul
Externí odkaz:
https://doaj.org/article/eefb59a1c28e4526a0bb4b17c9589c59
Autor:
Joseph P. Clarke, Patricia A. Thibault, Sakina Fatima, Hannah E. Salapa, Subha Kalyaanamoorthy, Aravindhan Ganesan, Michael C. Levin
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
The RNA binding protein heterogeneous nuclear ribonucleoprotein A1 (A1) regulates RNA metabolism, which is crucial to maintaining cellular homeostasis. A1 dysfunction mechanistically contributes to reduced cell viability and loss, but molecular mecha
Externí odkaz:
https://doaj.org/article/e9a6b9cc5b554f6ca0e0e99458443344
Autor:
Ali Jahanbazi Jahan‐Abad, Hannah E. Salapa, Cole D. Libner, Patricia A. Thibault, Michael C. Levin
Publikováno v:
Glia. 71:633-647
Oligodendrocyte (OL) damage and death are prominent features of multiple sclerosis (MS) pathology, yet mechanisms contributing to OL loss are incompletely understood. Dysfunctional RNA binding proteins (RBPs), hallmarked by nucleocytoplasmic mislocal
Publikováno v:
J Virol
A liver-specific microRNA, miR-122, anneals to the hepatitis C virus (HCV) genomic 5′ terminus and is essential for virus replication in cell culture. However, bicistronic HCV replicons and full-length RNAs with specific mutations in the 5′ untra
Autor:
Benhur Lee, Robert M. Cox, Jose R. Marengo, Negar Makhsous, Mart Toots, Jeong-Joong Yoon, Richard K. Plemper, Mugunthan Govindarajan, Satoshi Ikegame, Alexander L. Greninger, Michael G. Natchus, Ruth E. Watkinson, Michelle J. Lin, Julien Sourimant, Zachary M. Sticher, Alexander A. Kolykhalov, Patricia A. Thibault
Publikováno v:
Nature microbiology
Paramyxoviruses such as human parainfluenza virus type-3 (HPIV3) and measles virus (MeV) are a substantial health threat. In a high-throughput screen for inhibitors of HPIV3 (a major cause of acute respiratory infection), we identified GHP-88309—a
Autor:
Amy Lam, Orville O. Kirkland, Papa Freduah Anderson, Nandini Seetharaman, Dragan Vujovic, Patricia A. Thibault, Kristopher D. Azarm, Benhur Lee, Robert J. Rawle
Publikováno v:
Biophys J
Sendai virus (SeV, formally murine respirovirus) is a membrane-enveloped, negative-sense RNA virus in the Paramyxoviridae family and is closely related to human parainfluenza viruses. SeV has long been utilized as a model paramyxovirus and has recent